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Three subsets of sequence complexity and their relevance to biopolymeric information - David L Abel and Jack T Trevors: Excerpt: Genetic algorithms instruct sophisticated biological organization. Three qualitative kinds of sequence complexity exist: random (RSC), ordered (OSC), and functional (FSC). FSC alone provides algorithmic instruction...No empirical evidence exists of either RSC of OSC ever having produced a single instance of sophisticated biological organization...It is only in researching the pre-RNA world that the problem of single-stranded metabolically functional sequencing of ribonucleotides (or their analogs) becomes acute. http://www.biomedcentral.com/content/pdf/1742-4682-2-29.pdf Doug Axe humorously dismantled one of the latest ploys by materialists to oversell their meager evidence for a "self-replicating RNA molecule" in this following article: Biologic Institute Announces First Self-Replicating Motor Vehicle - Doug Axe - Excerpt: "So, advertising this as “self-replication” is a bit like advertising something as “free” when the actual deal is 1 free for every 1,600 purchased. It’s even worse, though, because you need lots of the pre-made precursors in cozy proximity to a finished RNA in order to kick the process off. That makes the real deal more like n free for every 1,600 n purchased, with the caveats that n must be a very large number and that full payment must be made in advance." http://biologicinstitute.org/2009/04/01/biologic-institute-announces-first-self-replicating-motor-vehicle/ Stephen Meyer points out that intelligence design was clearly required for even this meager result: Biological Information: The Puzzle of Life that Darwinism Hasn’t Solved - Stephen C. Meyer Thus, as my book Signature in the Cell shows, Joyce’s experiments not only demonstrate that self-replication itself depends upon information-rich molecules, but they also confirm that intelligent design is the only known means by which information arises. http://www.evolutionnews.org//2009/06/biological_information_the_puz.html Stephen Meyer Responds to Fletcher in Times Literary Supplement - Jan. 2010 Excerpt: everything we know about RNA catalysts, including those with partial self-copying capacity, shows that the function of these molecules depends upon the precise arrangement of their information-carrying constituents (i.e., their nucleotide bases). Functional RNA catalysts arise only once RNA bases are specifically-arranged into information-rich sequences—that is, function arises after, not before, the information problem has been solved. http://www.evolutionnews.org/2010/01/stephen_meyer_responds_to_flet.html Materialists have not even created all 4 "letters" of RNA by natural means: Response to Darrel Falk’s Review of Signature in the Cell - Stephen Meyer - Jan. 2010 Excerpt: Sutherland’s work only partially addresses the first and least severe of these difficulties: the problem of generating the constituent building blocks or monomers in plausible pre-biotic conditions. It does not address the more severe problem of explaining how the bases in nucleic acids (either DNA or RNA) acquired their specific information-rich arrangements. http://www.signatureinthecell.com/responses/response-to-darrel-falk.php Stirring the Soup - May 2009 "essentially, the scientists have succeeded in creating a couple of letters of the biological alphabet (in a "thermodynamically uphill" environment). What they need to do now is create the remaining letters, and then show how these letters were able to attach themselves together to form long chains of RNA, and arrange themselves in a specific order to encode information for creating specific proteins, and instructions to assemble the proteins into cells, tissues, organs, systems, and finally, complete phenotypes." Uncommon Descent - C Bass: http://www.uncommondescent.com/intelligent-design/stirring-the-soup/#comments Scientists Say Intelligent Designer Needed for Origin of Life Chemistry Excerpt: Organic chemist Dr. Charles Garner recently noted in private correspondence that "while this work helps one imagine how RNA might form, it does nothing to address the information content of RNA. So, yes, there was a lot of guidance by an intelligent chemist." Sutherland's research produced only 2 of the 4 RNA nucleobases, and Dr. Garner also explained why, as is often the case, "the basic chemistry itself also required the hand of an intelligent chemist." http://www.evolutionnews.org/2009/07/scientists_say_intelligent_des.html#more Meyer Responds to Stephen Fletcher - Stephen Meyer - March 2010 Excerpt: Nevertheless, this work does nothing to address the much more acute problem of explaining how the nucleotide bases in DNA or RNA acquired their specific information-rich arrangements, which is the central topic of my book (Signature In The Cell). In effect, the Powner (Sutherland) study helps explain the origin of the “letters” in the genetic text, but not their specific arrangement into functional “words” or “sentences.” http://www.evolutionnews.org/2010/03/meyer_responds_to_stephen_flet.html Origin of Life: Claiming Something for Almost Nothing Excerpt: Yarus admitted, “the tiny replicator has not been found, and that its existence will be decided by experiments not yet done, perhaps not yet imagined.” But does this (laboratory) work support a naturalistic origin of life? A key question is whether a (self-replicating) molecule could form under plausible prebiotic conditions. Here’s how the paper described their work in the lab to get this (precursor) molecule: RNA was synthesized by Dharmacon. GUGGC = 5’-GUGGC-30 ; GCCU – 5’P-GCCU-3’ ; 5’OH-GCCU = 5’-GCCU-3’ ; GCCU20dU = 5’-GCC-2’-dU; GCC = 5’-GCC-3’ ; dGdCdCrU = 5’-dGdCdCU-3’ . RNA GCC3’dU was prepared by first synthesizing 5’-O-(4,4’- Dimethoxytrityl)3’-deoxyuridine as follows: 3’-deoxyuridine (MP Biomedicals; 991 mg, 0.434 mmol) was dissolved in 5 mL anhydrous pyridine and pyridine was then removed under vacuum while stirring. Solid was then redissolved in 2 mL pyridine. Dimethoxytrityl chloride (170 mg, 0.499 mmol) was dissolved in 12 mL pyridine and slowly added to 3’-deoxyuridine solution. Solution was stirred at room temperature for 4 h. All solutions were sequestered from exposure to air throughout. Reaction was then quenched by addition of 5 mL methanol, and solvent was removed by rotary evaporation. Remaining solvent evaporated overnight in a vacuum chamber. Product was then dissolved in 1 mL acetonitrile and purified through a silica column (acetonitrile elution). Final product fractions (confirmed through TLC, 1.1 hexane:acetonitrile) were pooled and rotary evaporated. Yield was 71%. Dimethoxytrityl-protected 30dU was then sent to Dharmacon for immobilization of 30-dU on glass and synthesis of 5’-GCC-3’-dU. PheAMP, PheUMP, and MetAMP were synthesized by the method of Berg (25) with modifications and purification as described in ref. 6. Yield was as follows: PheAMP 85%, PheUMP 67%, and MetAMP 36%. Even more purification and isolation steps under controlled conditions, using multiple solvents at various temperatures, were needed to prevent cross-reactions. (then this understatement follows) It is doubtful such complex lab procedures have analogues in nature. http://www.creationsafaris.com/crev201003.htm#20100302a Here are some more critiques of the "RNA World" scenario: Did Life Begin in an RNA World? http://www.creationsafaris.com/crev0702.htm#abiogenesis62 Self Replication and Perpetual Motion - The Second Law's Take On The RNA World http://theory-of-evolution.net/chap10/self-replicating-RNA-perpetual-motion-4.php The RNA World: A Critique - Gordon Mills and Dean Kenyon: http://www.arn.org/docs/odesign/od171/ribo171.htm Intelligent Design - The Anthropic Hypothesis http://lettherebelight-77.blogspot.com/
2 May 2010
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"there are no known violations of the second law of thermodynamics. Ordinarily the second law is stated for isolated systems, but the second law applies equally well to open systems." John Ross, Chemical and Engineering News, 7 July 1980 Can “ANYTHING” Happen in an Open System? - Granville Sewell Excerpt: If we found evidence that DNA, auto parts, computer chips, and books entered through the Earth’s atmosphere at some time in the past, then perhaps the appearance of humans, cars, computers, and encyclopedias on a previously barren planet could be explained without postulating a violation of the second law here (it would have been violated somewhere else!). *******www.math.utep.edu/Faculty/sewell/articles/appendixd.pdf Evolution's Thermodynamic Failure - Granville Sewell (Professor of Mathematics Texas University - El Paso) *******www.spectator****/dsp_article.asp?art_id=9128 Walter L. Bradley, Information, Entropy, and the Origin of Life: Excerpt: He clarifies the distinction between configurational and thermal entropy, and shows why materialistic theories of chemical evolution have not explained the configurational entropy present in living systems, a feature of living systems that Bradley takes to be strong evidence of intelligent design. *******www.discovery****/a/2640 The ID argument from thermodynamics: Excerpt: "energy cannot create CSI (Complex Specified Information)." *******www.uncommondescent****/intelligent-design/the-id-argument-from-thermodynamics/#more-9090 Mathematical refutation of the open system entropy argument - by Kairosfocus *******www.angelfire****/pro/kairosfocus/resources/Info_design_and_science.htm#thermod Conservation of Information In Search - William Dembski and Robert Marks - Sept. 2009 *******ieeexplore.ieee****/xpl/freeabs_all.jsp?isnumber=5208652&arnumber=5204206 Water is considered a 'universal solvent' which is a very thermodynamic obeying and thus origin of life defying fact. Professor Arthur E. Wilder-Smith "Any amounts of polypeptide which might be formed will be broken down into their initial components (amino acids) by the excess of water. The ocean is thus practically the last place on this or any other planet where the proteins of life could be formed spontaneously from amino acids. Yet nearly all text-books of biology teach this nonsense to support evolutionary theory and spontaneous biogenesis ... Has materialistic Neo-Darwinian philosophy overwhelmed us to such an extent that we forget or overlook the well-known facts of science and of chemistry in order to support this philosophy? ... Without exception all Miller's amino acids are completely unsuitable for any type of spontaneous biogenesis. And the same applies to all and any randomly formed substances and amino acids which form racemates. This statement is categorical and absolute and cannot be affected by special conditions." *******theevolutioncrisis*******/testimony3.php Sea Salt only adds to this thermodynamic problem. ...even at concentrations seven times weaker than in today’s oceans. The ingredients of sea salt are very effective at dismembering membranes and preventing RNA units (monomers) from forming polymers any longer than two links (dimers). Creation Evolution News - Sept. 2002 Refutation Of Hyperthermophile Origin Of Life scenario Excerpt: While life, if appropriately designed, can survive under extreme physical and chemical conditions, it cannot originate under those conditions. High temperatures are especially catastrophic for evolutionary models. The higher the temperature climbs, the shorter the half-life for all the crucial building block molecules, *******www.reasons****/LateHeavyBombardmentIntensityandtheOriginofLife Chemist explores the membranous origins of the first living cell: Excerpt: Conditions in geothermal springs and similar extreme environments just do not favor membrane formation, which is inhibited or disrupted by acidity, dissolved salts, high temperatures, and calcium, iron, and magnesium ions. Furthermore, mineral surfaces in these clay-lined pools tend to remove phosphates and organic chemicals from the solution. "We have to face up to the biophysical facts of life," Deamer said. "Hot, acidic hydrothermal systems are not conducive to self-assembly processes." *******currents.ucsc.edu/05-06/04-03/deamer.asp Self Replication and Perpetual Motion - The Second Law's Take On The RNA World *******theory-of-evolution****/chap10/self-replicating-RNA-perpetual-motion-4.php Three subsets of sequence complexity and their relevance to biopolymeric information - David L Abel and Jack T Trevors: Excerpt: Genetic algorithms instruct sophisticated biological organization. Three qualitative kinds of sequence complexity exist: random (RSC), ordered (OSC), and functional (FSC). FSC alone provides algorithmic instruction...No empirical evidence exists of either RSC of OSC ever having produced a single instance of sophisticated biological organization...It is only in researching the pre-RNA world that the problem of single-stranded metabolically functional sequencing of ribonucleotides (or their analogs) becomes acute. *******www.biomedcentral****/content/pdf/1742-4682-2-29.pdf The Capabilities of Chaos and Complexity - David L. Abel - 2009 Excerpt: "A monstrous ravine runs through presumed objective reality. It is the great divide between physicality and formalism. On the one side of this Grand Canyon lies everything that can be explained by the chance and necessity of physicodynamics. On the other side lies those phenomena than can only be explained by formal choice contingency and decision theory—the ability to choose with intent what aspects of ontological being will be preferred, pursued, selected, rearranged, integrated, organized, preserved, and used. Physical dynamics includes spontaneous non linear phenomena, but not our formal applied-science called “non linear dynamics”(i.e. language,information). *******www.mdpi****/1422-0067/10/1/247/pdf "No man-made program comes close to the technical brilliance of even Mycoplasmal genetic algorithms. Mycoplasmas are the simplest known organism with the smallest known genome, to date. How was its genome and other living organisms' genomes programmed?" - David L. Abel and Jack T. Trevors, “Three Subsets of Sequence Complexity and Their Relevance to Biopolymeric Information,” Theoretical Biology & Medical Modelling, Vol. 2, 11 August 2005, page 8 *******www.biomedcentral****/content/pdf/1742-4682-2-29.pdf The Physics of the Small and Large: What is the Bridge Between Them? Roger Penrose Excerpt: "The time-asymmetry is fundamentally connected to with the Second Law of Thermodynamics: indeed, the extraordinarily special nature (to a greater precision than about 1 in 10^10^123, in terms of phase-space volume) can be identified as the "source" of the Second Law (Entropy)." *******www.pul.it/irafs/CD%20IRAFS%2702/texts/Penrose.pdf How special was the big bang? - Roger Penrose Excerpt: "This now tells us how precise the Creator's aim must have been: namely to an accuracy of one part in 10^10^123." *******www.ws5****/Penrose/ This 1 in 10^10^123 number, for the time-asymmetry of the initial state of entropy (or order) for the universe, also lends strong support for "highly specified infinite information" creating the universe since the universe, as a whole, has been losing order ever since the big bang; "Gain in entropy always means loss of information, and nothing more." Gilbert Newton Lewis Conservation Of Transcendent Information - 2007 - video *******www.metacafe****/watch/3995275/intelligent_design_conservation_of_transcendent_information/ Scientific Evidence For God (Logos) Creating The Universe - 2008 - video *******www.metacafe****/watch/3995300/scientific_evidence_for_god_logos_creating_the_universe/ "Information is information, not matter or energy. No materialism which does not admit this can survive at the present day." Norbert Weiner - MIT Mathematician - Father of Cybernetics Intelligent Design - The Anthropic Hypothesis *******lettherebelight-77.blogspot****/
8 Mar 2010
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