Leighton Meester in The Roommate Thought your only worry that first year of college would be the Freshman fifteen? Leighton Meester gives Minka Kelly a crash course in crazy as her psychotic new roommate. Watch It.

Megan Fox in Jennifer's Body Diablo Cody brings Megan Fox to the next level as a modern-day succubus wreaking havoc on her small town. A girl that pretty has to be at least a little evil, right? Watch It.

Cameron Diaz in Vanilla Sky Love 'em and leave 'em? Cameron Diaz proves she's one chick you just don't forget about. Watch It.

Eihi Shiina in Audition Eihi Shiina reps J-horror in all its glory as an ex-ballerina with a penchant for dismemberment. Watch It.

Erika Christensen in Swimfan Didn't your mama tell you not to sleep with crazy girls? Erika gives "Bring It On" hunk Jesse Bradford a one night stand that'll keep you on the edge of your seat. Watch It.

Ali Larter in Obsessed Sexy secretaries? Cheating husbands? No, it's the epic Ali Larter-Beyonce smackdown that makes Obsessed the instant classic it is. Watch It.

Natalie Portman in Black Swan Natalie Portman's Oscar-winning portrayal of an obsessive ballerina earns this psychological horror flick a primo spot on our list. Watch It.

Sissy Spacek in Carrie Hell hath no fury like a teenage girl. Carrie brings a new terror to telekinesis as she uses her supernatural powers to bring down her tormentors, one by one. Watch It.

Drew Barrymore in Poison Ivy Baby-faced Drew Barrymore steps it up a notch as a teenage seductress in this 90s psycho-thriller. Watch It.

Alicia Silverstone in The Crush When Lolita-aged Alica Silverstone gets rejected by news reporter Cary Elwes, no one is safe from her murderous, hormonal girl-rage. Watch It.

Glenn Close in Fatal Attraction Glenn Close stars as the mother of all casual flings gone bad. Watch It.

Sharon Stone in Basic Instinct If you're in the need for a psycho chick icon, Sharon Stone's as far as you need to look. Watch It.

Jennifer Jason Leigh in Single White Female Ever have second thoughts about that rando roomie you found off Craigslist? You've been warned. Watch It.

Nicole Kidman in To Die For Ambition is usually a positive quality, but Nicole Kidman's murderous drive gives the word a deadly new meaning. Watch It.

Rebecca De Mornay in The Hand That Rocks the Cradle Lesson learned: never trust the nanny and always get that second background check. Watch It.

Juliette Lewis in Natural Born Killers Fame-hungry, sex-addicted, and blood-thirsty Mallory Knox doesn't think, she just does. Watch It.

Mischa Barton in Homecoming What does Mischa Barton do when her hometown hero ex comes back from college? Murder his new girlfriend, naturally. Watch It.

Susan Sarandon as Sophie Hartley Susan Sarandon fights tooth and nail to protect her family from a wannabe homebreaker, but sometimes these situations aren't always as simple as they might seem. Watch It.

Neve Campbell in Wild Things With more twists than a bag of pretzels, Wild Things will make your head spin. Trying to pinpoint the true Suzie Troller is hand's down the most thrilling part of this film. Watch It.

Kathy Bates in Misery She's his biggest fan and she's planning on spending some quality time with him, no matter the price. Watch It.

Mila Kunis in American Psycho II Who knew the taste for blood could be infectious? Watch It.