Refuting Darwinian Evolution - Jon Rittenhouse - video
What evidence is found for the first life on earth? - article
Dean Kenyon, who was a leading Origin Of Life researcher as well as a college textbook author on the subject in the 1970s, admitted after years of extensive research:
"We have not the slightest chance for the chemical evolutionary origin of even the simplest of cells".
Origin Of Life? - Probability Of Protein And The Information Of DNA - Dean Kenyon - video
Programming of Life - Probability of a Cell Evolving - video
Probability Of A Protein and First Living Cell - Chris Ashcraft - video (notes in description)
The Origin of Life - Lecture On Probability - John Walton - Professor Of Chemistry - short video
Protein Molecules and "Simple" Cells - video
Evolution: Possible or Impossible? - free e-book (with plenty of examples from math) - by Dr. James F. Coppedge
Stephen Meyer - Proteins by Design - Doing The Math - video
Centre for Intelligent Design Lecture 2011 by Stephen Meyer on 'Signature in the Cell' - video
Signature in the Cell - Book Review - Ken Peterson
Excerpt: If we assume some minimally complex cell requires 250 different proteins then the probability of this arrangement happening purely by chance is one in 10 to the 164th multiplied by itself 250 times or one in 10 to the 41,000th power.
In fact years ago Fred Hoyle arrived at approximately the same number, one chance in 10^40,000, for life spontaneously arising. From this number, Fred Hoyle compared the random emergence of the simplest bacterium on earth to the likelihood “a tornado sweeping through a junkyard might assemble a Boeing 747 therein”. Fred Hoyle also compared the chance of obtaining just one single functioning protein molecule, by chance combination of amino acids, to a solar system packed full of blind men solving Rubik’s Cube simultaneously.
Professor Harold Morowitz shows the Origin of Life 'problem' escalates dramatically over the 1 in 10^40,000 figure when working from a thermodynamic perspective,:
"The probability for the chance of formation of the smallest, simplest form of living organism known is 1 in 10^340,000,000. This number is 10 to the 340 millionth power! The size of this figure is truly staggering since there is only supposed to be approximately 10^80 (10 to the 80th power) electrons in the whole universe!"
(Professor Harold Morowitz, Energy Flow In Biology pg. 99, Biophysicist of George Mason University)
Dr. Don Johnson lays out some of the probabilities for life in this following video:
Probabilities Of Life - Don Johnson PhD. - 38 minute mark of video
a typical functional protein - 1 part in 10^175
the required enzymes for life - 1 part in 10^40,000
a living self replicating cell - 1 part in 10^340,000,000
Increasing Genomic Information - Don Johnson - video
Excerpt: Forming the simplest life is 10^300,000,000 more likely that forming a human life
Dr. Morowitz did another probability calculation working from the thermodynamic perspective with a already existing cell and came up with this number:
DID LIFE START BY CHANCE?
Excerpt: Molecular biophysicist, Horold Morowitz (Yale University), calculated the odds of life beginning under natural conditions (spontaneous generation). He calculated, if one were to take the simplest living cell and break every chemical bond within it, the odds that the cell would reassemble under ideal natural conditions (the best possible chemical environment) would be one chance in 10^100,000,000,000. You will have probably have trouble imagining a number so large, so Hugh Ross provides us with the following example. If all the matter in the Universe was converted into building blocks of life, and if assembly of these building blocks were attempted once a microsecond for the entire age of the universe. Then instead of the odds being 1 in 10^100,000,000,000, they would be 1 in 10^99,999,999,916 (also of note: 1 with 100 billion zeros following would fill approx. 20,000 encyclopedias)
Punctured cell will never reassemble - Jonathan Wells - 2:40 mark of video
The Humpty-Dumpty Effect: A Revolutionary Paper with Far-Reaching Implications - Paul Nelson - October 23, 2012
Excerpt: Tompa and Rose calculate the "total number of possible distinct patterns of interactions," using yeast, a unicellular eukaryote, as their model system; this "total number" is the size of the space that must be searched. With approximately 4,500 proteins in yeast, the interactome search space "is on the order of 10^7200, an unimaginably large number," they write -- but "more realistic" estimates, they continue, are "yet more complicated." Proteins present many possible surfaces for chemical interaction. "In all," argue Tompa and Rose, "an average protein would have approximately 3540 distinguishable interfaces," and if one uses this number for the interactome space calculation, the result is 10 followed by the exponent 7.9 x 10^10.,,, the numbers preclude formation of a functional interactome (of 'simple' life) by trial and error,, within any meaningful span of time. This numerical exercise...is tantamount to a proof that the cell does not organize by random collisions of its interacting constituents. (i.e. that life did not arise, nor operate, by chance!)
Also of interest is the information content that is derived in a cell when working from a thermodynamic perspective:
“a one-celled bacterium, e. coli, is estimated to contain the equivalent of 100 million pages of Encyclopedia Britannica. Expressed in information in science jargon, this would be the same as 10^12 bits of information. In comparison, the total writings from classical Greek Civilization is only 10^9 bits, and the largest libraries in the world – The British Museum, Oxford Bodleian Library, New York Public Library, Harvard Widenier Library, and the Moscow Lenin Library – have about 10 million volumes or 10^12 bits.” – R. C. Wysong
'The information content of a simple cell has been estimated as around 10^12 bits, comparable to about a hundred million pages of the Encyclopedia Britannica."
Carl Sagan, "Life" in Encyclopedia Britannica: Macropaedia (1974 ed.), pp. 893-894
of note: The 10^12 bits of information number for a bacterium is derived from entropic considerations, which is, due to the tightly integrated relationship between information and entropy, considered the most accurate measure of the transcendent quantum information/entanglement constraining a 'simple' life form to be so far out of thermodynamic equilibrium.
"Is there a real connection between entropy in physics and the entropy of information? ....The equations of information theory and the second law are the same, suggesting that the idea of entropy is something fundamental..." Siegfried, Dallas Morning News, 5/14/90, [Quotes Robert W. Lucky, Ex. Director of Research, AT&T, Bell Laboratories & John A. Wheeler, of Princeton & Univ. of TX, Austin]
For calculations, from the thermodynamic perspective, please see the following site:
Moleular Biophysics – Information theory. Relation between information and entropy: - Setlow-Pollard, Ed. Addison Wesley
Excerpt: Linschitz gave the figure 9.3 x 10^12 cal/deg or 9.3 x 10^12 x 4.2 joules/deg for the entropy of a bacterial cell. Using the relation H = S/(k In 2), we find that the information content is 4 x 10^12 bits. Morowitz' deduction from the work of Bayne-Jones and Rhees gives the lower value of 5.6 x 10^11 bits, which is still in the neighborhood of 10^12 bits. Thus two quite different approaches give rather concordant figures.
Ilya Prigogine was an eminent chemist and physicist who received two Nobel Prizes in chemistry. Regarding the probability of life originating by accident, he said:
“The statistical probability that organic structures and the most precisely harmonized reactions that typify living organisms would be generated by accident, is zero.”
Ilya Prigogine, Gregoire Nicolis, and Agnes Babloyantz, Physics Today 25, pp. 23-28.
Quotes of Note:
The Theist holds the Intellectual High-Ground - March 2011
Excerpt: To get a range on the enormous challenges involved in bridging the gaping chasm between non-life and life, consider the following: “The difference between a mixture of simple chemicals and a bacterium, is much more profound than the gulf between a bacterium and an elephant.”
(Dr. Robert Shapiro, Professor Emeritus of Chemistry, NYU)
Scientists Prove Again that Life is the Result of Intelligent Design - Rabbi Moshe Averick - August 2011
Excerpt: “To go from bacterium to people is less of a step than to go from a mixture of amino acids to a bacterium.” - Dr. Lynn Margulis
Stephen Meyer - The Scientific Basis for the Intelligent Design Inference - video