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2:08
Rich Gallup, Jeff Gerstmann, and Brian Ekberg wax philosophical about drafting in NASCAR SimRacing. For more information on GameSpot's tournaments, visit *******www.gamespot****/features.html?type=features&category=Tournaments
18 Oct 2006
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1:44
In the word's of Jeff Gerstmann, "we like short tracks because you see more wrecks." Or something. For more information on GameSpot's tournaments, visit *******www.gamespot****/features.html?type=features&category=Tournaments
17 Oct 2006
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2:56
"Cynthia Witthoft" "The Kuru Disease" "Last Recordings Before My Suicide - 2008" - Kuru, or Creutzfeldt-Jakob disease (CJD), is a very rare and incurable degenerative neurological disorder (brain disease) that is ultimately fatal. Among the types of transmissible spongiform encephalopathy found in humans, it is the most common. Transmissible spongiform encephalopathy diseases are caused by prions. The diseases are thus sometimes called prion diseases. Other prion diseases include Gerstmann-Sträussler-Scheinker syndrome (GSS), fatal familial insomnia (FFI) and kuru in humans, as well as bovine spongiform encephalopathy (BSE) commonly known as mad cow disease, chronic wasting disease (CWD) in elk and deer, and scrapie in sheep. The prion that is believed to cause Creutzfeldt-Jakob exhibits at least two stable conformations. One, the native state, is water-soluble and present in healthy cells. As of 2007, its biological function is presumably in transmembrane transport or signaling. The other conformational state is very poorly water-soluble and readily forms protein aggregates. People can also acquire CJD genetically through a mutation of the gene that codes for the prion protein(PRNP). This only occurs in 5-10% of all CJD cases. The CJD prion is dangerous because it promotes refolding of native proteins into the diseased state. The number of misfolded protein molecules will increase exponentially, and the process leads to a large quantity of insoluble prions in affected cells. This mass of misfolded proteins disrupts cell function and causes cell death. Mutations in the gene for the prion protein can cause a misfolding of the dominantly alpha helical regions into beta pleated sheets. This change in conformation disables the ability of the protein to undergo digestion. Once the prion is transmitted, the defective proteins invade the brain and are produced in a self-sustaining feedback loop, causing exponential spread of the prion, death within a few months, although a few patients have been known to live as long as two years. Stanley B. Prusiner was awarded the Nobel Prize in physiology or medicine in 1997 for his discovery of prions. For more than a decade, Yale University neuropathologist Laura Manuelidis has been challenging this explanation for the disease. In January 2007 she and her colleagues published an article in the Proceedings of the National Academy of Science and reported that they have found a virus-like particle (but without finding nucleic acids so far) in less than 10% of the cells a scrapie-infected cell line and in a mouse cell line infected by a human CJD agent. The first symptom of CJD is rapidly progressive dementia, leading to memory loss, personality changes, inappropriate and unmotivated laughter, and hallucinations. This is accompanied by physical problems such as speech impairment, jerky movements (myoclonus), balance and coordination dysfunction (ataxia), changes in gait, rigid posture, and seizures. The duration of the disease varies greatly, but sporadic (non-inherited) CJD can be fatal within months or even weeks. In some people, the symptoms can continue for years. In most patients, these symptoms are followed by involuntary movements and the appearance of a typical diagnostic electroencephalogram tracing. The symptoms of CJD are caused by the progressive death of the brain's nerve cells, which is associated with the build-up of abnormal prion proteins. When brain tissue from a CJD patient is examined under a microscope, many tiny holes can be seen where whole areas of nerve cells have died. The word 'spongiform' in 'transmissible spongiform encephalopathies' refers to the 'spongy' appearance of the brain tissue. [Emotions may switch suddenly from sadness to happiness with sudden outbursts of laughter. People with kuru become demented and eventually placid, unable to speak, and unresponsive to their surroundings. Most people die about 3 to 24 months after symptoms appear, usually as a result of pneumonia or infection due to bedsores (pressure sores).]
26 Jan 2010
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4:24
Apparently, this review got him fired from Gamespot. Now he works for *******www.giantbomb****
3 Jul 2011
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3:42
In this video review, Jeff Gerstmann compares the differences between the GameCube and PS2 versions."The GameCube version may be less jaggy than the original PS2 release, but its lack of online multiplayer and somewhat sketchy frame rate keep it from living up to its full potential."
15 Mar 2010
123
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6:03
The Grand Theft Auto series has always had a buzz of controversy surrounding it. With Grand Theft Auto III, DMA Designs has taken the series to a whole new level by bringing it into a fully 3D world, with all of the hard-boiled violence that you've come to expect from these games. GameSpot's Jeff Gerstmann details just about everything you need to know about this over-the-top game."Grand Theft Auto III is, quite simply, an incredible experience that shouldn't be missed by anyone mature enough to handle it."
15 Mar 2010
183
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3:49
Jeff Gerstmann gives the final word on Grand Theft Auto's evolution on the PSP."Liberty City Stories has its share of minor issues, but it gets enough of the GTA look and feel in there to be an exciting portable game overall."
17 Mar 2010
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10:29
GameSpot's Jeff Gerstmann sits down to talk about Rockstar's Grand Theft Auto: Vice City."Grand Theft Auto: Vice City provides just about everything you'd want in a follow-up to an outstanding game."
18 Mar 2010
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0:57
Oregon Trail in 60 seconds from Gamespot**** by Jeff Gerstmann.
19 Mar 2010
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6:03
GameSpot's Jeff Gerstmann explains in great detail what makes Dead or Alive Xtreme Beach Volleyball a graphical showcase and not much else."Dead or Alive Xtreme Beach Volleyball is a graphical showcase that makes for a pretty uneventful game."
1 Apr 2010
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2:48
Go behind-the-scenes at giantbomb**** with your host, Jeff Gerstmann.
31 Jul 2011
153
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10:57
Jeff Gerstmann and Eddie Makuch cover all points revealed in the PlayStation 4 unveiling.
21 Feb 2013
168
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10:58
Jeff Gerstmann and Eddie Makuch cover all points revealed in the PlayStation 4 unveiling. Stay up to date by subscribing to GameSpot news! *******www.youtube****/show/gsnews Watch all the videos from the event: *******www.youtube****/watch?v=oez_gvMxOF0&list=SPpg6WLs8kxGN5IwsBA9QQk29S2_Sdgd2Q For more PS4 coverage, visit: *******www.gamespot****/ps4/ Visit our other channels: Gameplay & Guides - *******www.youtube****/gamespotgameplay Trailers - *******www.youtube****/gamespottrailers MLG, NASL & eSports - *******www.youtube****/gamespotesports Mobile Gaming - *******www.youtube****/gamespotmobile Like - *******www.facebook****/GameSpot Follow - *******www.twitter****/GameSpot Stream Live - *******twitch.tv/GameSpot *******www.gamespot****/
27 Feb 2013
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