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The lymphatic system is a vascular network of tubules and ducts that collect, filter, and return lymph to blood circulation. Lymph is a clear fluid that comes from blood plasma, which exits blood vessels at capillary beds. This fluid becomes the interstitial fluid that surrounds cells. Lymph contains water, proteins, salts, lipids, white blood cells, and other substances that must be returned to the blood. The primary functions of the lymphatic system are to drain and return interstitial fluid to the blood, to absorb and return lipids from the digestive system to the blood, and to filter fluid of pathogens, damaged cells, cellular debris, and cancerous cells.
Lymphatic System Structures
The major components of the lymphatic system include lymph, lymphatic vessels, and lymphatic organs that contain lymphoid tissues.
Lymphatic vessels are structures that absorb fluid that diffuses from blood vessel capillaries into surrounding tissues. This fluid is directed toward lymph nodes to be filtered and ultimately re-enters blood circulation through veins located near the heart. The smallest lymphatic vessels are called lymph capillaries. Lymphatic capillaries come together to form larger lymphatic vessels. Lymphatic vessels from various regions of the body merge to form larger vessels called lymphatic trunks. Lymphatic trunks merge to form two larger lymphatic ducts. Lymphatic ducts return lymph to blood circulation by draining lymph into the subclavian veins in the neck.
Lymphatic vessels transport lymph to lymph nodes. These structures filter lymph of pathogens, such as bacteria and viruses . Lymph nodes also filter cellular waste, dead cells, and cancerous cells. Lymph nodes house immune cells called lymphocytes. These cells are necessary for the development of humoral immunity defense prior to cell infection and cell-mediated immunity defense after cell infection. Lymph
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