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Translational machinery, which makes proteins in all cells using instructions encoded in the gene. This process involves the ribosome and its interaction with mRNA, tRNA and various protein factors. This video is from the lab of Venkataraman Ramakrishnan who was Joint-winner of 2009 Nobel Prize for Chemistry. For his work on a neutron-scattering map of the RNA of ribosomes, the protein-making structures in cells. - *******indiaunfinished.wordpress****/2009/10/07/venkataraman-ramakrishnan/ Here is his lab page: Ribosome Structure and Function *******www.mrc-lmb.cam.ac***/ribo/homepage/index.html Ramakrishnan described his work on ribosomes as an attempt to understand “this large molecular machine that takes information from genes and uses it to stitch together protein.” He said he and others had been using X-ray crystallography to build an “atomic picture of this enormous machine.” for a bit more detail on what is happening in the featured video check out these following videos: Journey Inside The Cell - video *******www.journeyinsidethecell****/ Stephen Meyer - Functional Proteins And Information For Body Plans - video *******www.metacafe****/watch/4050681/stephen_meyer_functional_proteins_and_information_for_body_plans/ Intelligent Design - The Anthropic Hypothesis *******lettherebelight-77.blogspot****/
9 Sep 2011
6529
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1:27
Simulations reveal new information about the gateway to the cell nucleus Excerpt: “There are whole machines in living cells that are made of hundreds or thousands of proteins,” says Schulten, “and the nuclear pore is one of those systems. It’s actually one of the most magnificent systems in the cell.”,,,Hundreds to thousands of NPCs are embedded in the nuclear envelope of each cell,"... *******www.psc.edu/science/2006/schulten/ Nuclear pore: Excerpt: Nuclear pores allow the transport of water-soluble molecules across the nuclear envelope. This transport includes RNA and ribosomes moving from nucleus to the cytoplasm and proteins (such as DNA polymerase and lamins), carbohydrates, signal molecules and lipids moving into the nucleus. It is notable that the nuclear pore complex (NPC) can actively conduct 1000 translocations per complex per second. *******en.wikipedia****/wiki/Nuclear_pore#Transport_through_the_nuclear_pore_complex The Nuclear Pore Complex - Gateway to the Nucleus Excerpt: The nuclear pore complex (NPC), perhaps the largest protein complex in the cell, is responsible for the protected exchange of components between the nucleus and cytoplasm and for preventing the transport of material not destined to cross the nuclear envelope. *******www.ks.uiuc.edu/Research/npc/ The nuclear pore complex becomes alive: new insights into its dynamics and involvement in different cellular processes Excerpt: In this review we summarize the structure and function of the nuclear pore complex (NPC). Special emphasis is put on recent findings which reveal the NPC as a dynamic structure in the context of cellular events like nucleocytoplasmic transport, cell division and differentiation, stress response and apoptosis. Evidence for the involvement of nucleoporins in transcription and oncogenesis is discussed,,, *******atlasgeneticsoncology****/Deep/NuclearPoreComplID20048.html The Cell as a Collection of Protein Machines "We have always underestimated cells. Undoubtedly we still do today,,, Indeed, the entire cell can be viewed as a factory that contains an elaborate network of interlocking assembly lines, each which is composed of a set of large protein machines." Bruce Alberts: Former President, National Academy of Sciences; *******www.imbb.forth.gr/people/aeconomou/documents/Alberts98.pdf Bacterial Flagellum - A Sheer Wonder Of Intelligent Design - video *******www.metacafe****/watch/3994630/bacterial_flagellum_a_sheer_wonder_of_intelligent_design/ Stephen Meyer - Molecular Machines & Information *******www.metacafe****/watch/4146691/stephen_meyer_molecular_machines_information/ The Virus - Assembly Of A Molecular Machine - video *******www.metacafe****/watch/4023122/the_virus_assembly_of_a_molecular_machine_intelligent_design/ The Virus - A Molecular Lunar Landing Machine - video *******www.metacafe****/watch/4205494/the_virus_a_molecular_lunar_landing_machine/ Evolution vs ATP Synthase - Molecular Machine - video *******www.metacafe****/watch/4012706/evolution_vs_atp_synthase_molecular_machine/ Molecular Highway Motor Comes info Focus Excerpt: “kinesin proteins motor along microtubules like trains on a railroad track, towing cargo to various locations within cells and assisting in cell division.” Each rocking motion of the see-saw requires energy from ATP. *******www.creationsafaris****/crev201002.htm#20100219a Kinesin Transport Protein - video *******www.youtube****/watch?v=4TGDPotbJV4 Michael Behe - Lee Strobel - Molecular Machines *******www.metacafe****/watch/4209383/michael_behe_lee_strobel_molecular_machines/ Stephen Meyer - Functional Proteins And Information For Body Plans - video *******www.metacafe****/watch/4050681/stephen_meyer_functional_proteins_and_information_for_body_plans/ Intelligent Design - The Anthropic Hypothesis *******lettherebelight-77.blogspot****/
10 Mar 2010
15578
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9:41
Molecular Machine Bacterial Flagella - A Paradigm For Intelligent Design - Scott Minnich - entire video *******www.vimeo****/9032112 Scott Minnich homepage: *******www.cals.uidaho.edu/mmbb/minnich.asp The best known example for irreducible complexity, and thus for Intelligent Design, in molecular biology has become the bacterial flagellum. Bacterial Flagellum - A Sheer Wonder Of Intelligent Design - video *******www.metacafe****/watch/3994630/bacterial_flagellum_a_sheer_wonder_of_intelligent_design/ Biologist Howard Berg at Harvard calls the Bacterial Flagellum “the most efficient machine in the universe." The flagellum has steadfastly resisted all attempts to elucidate its plausible origination by Darwinian processes, much less has anyone ever actually evolved a flagellum from scratch in the laboratory; Genetic Entropy Refutation of Nick Matzke's TTSS (type III secretion system) to Flagellum Evolutionary Narrative: Excerpt: Comparative genomic analysis show that flagellar genes have been differentially lost in endosymbiotic bacteria of insects. Only proteins involved in protein export within the flagella assembly pathway (type III secretion system and the basal-body) have been kept... *******mbe.oxfordjournals****/cgi/content/abstract/msn153v1 "One fact in favour of the flagellum-first view is that bacteria would have needed propulsion before they needed T3SSs, which are used to attack cells that evolved later than bacteria. Also, flagella are found in a more diverse range of bacterial species than T3SSs. ‘The most parsimonious explanation is that the T3SS arose later," Howard Ochman - Biochemist - New Scientist (Feb 16, 2008) Michael Behe on Falsifying Intelligent Design - video *******www.youtube****/watch?v
7 Mar 2010
1366
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1:21
Evolution Vs ATP Synthase - Molecular Machine - video *******www.metacafe****/watch/4012706 Evolution Vs. Functional Proteins - Where Did The Information Come From? - Doug Axe - Stephen Meyer - video *******www.metacafe****/watch/4018222 "There are no detailed Darwinian accounts for the evolution of any fundamental biochemical or cellular system only a variety of wishful speculations. It is remarkable that Darwinism is accepted as a satisfactory explanation of such a vast subject." James Shapiro - Molecular Biologist ATP Synthase achieves nearly 100% efficiency which far surpasses any human engineered motor: A rotary molecular motor that can work at near 100% efficiency: Excerpt: In cells, the free energy of ATP hydrolysis is ca. 90 pN nm per ATP molecule, suggesting that the F1 motor can work at near 100% efficiency. We confirmed in vitro that F1 indeed does ca. 80 pN nm of work under the condition where the free energy per ATP is 90 pN nm. The high efficiency may be related to the fully reversible nature of the F1 motor: *******rstb.royalsocietypublishing****/content/355/1396/473.abstract Worlds Smallest Rotary Engine Highlighted Excerpt: The match implies 100% efficiency for the conversion of the Gibbs free energy of ATP hydrolysis into mechanical work performed on the elastically strained filament. This is not surprising given the approximate thermodynamic equilibrium of the enzyme (long)-filament construct. *******www.creationsafaris****/crev200905.htm#20090525a ATP: The Perfect Energy Currency for the Cell Jerry Bergman, Ph.D. *******www.trueorigin****/atp.asp Astonishingly, and to the dismay of atheistic evolutionists, actual motors, which far surpass man-made motors in 'engineering parameters', are now being found inside 'simple cells'. Articles and Videos on Molecular Motors *******docs.google****/Doc?docid=0AYmaSrBPNEmGZGM4ejY3d3pfMzlkNjYydmRkZw&hl=en Bacterial Flagellum - A Sheer Wonder Of Intelligent Design - video *******www.metacafe****/watch/3994630 Biologist Howard Berg at Harvard calls the Bacterial Flagellum “the most efficient machine in the universe." Michael Behe on Falsifying Intelligent Design - video *******www.youtube****/watch?v=N8jXXJN4o_A The Cell as a Collection of Protein Machines "We have always underestimated cells. Undoubtedly we still do today,,, Indeed, the entire cell can be viewed as a factory that contains an elaborate network of interlocking assembly lines, each which is composed of a set of large protein machines." Bruce Alberts: Former President, National Academy of Sciences; *******www.imbb.forth.gr/people/aeconomou/documents/Alberts98.pdf The Cell - A World Of Complexity Darwin Never Dreamed Of - Donald E. Johnson - video *******www.metacafe****/watch/4139390 The inner life of a cell - Harvard University - video *******www.youtube****/watch?v=BtZEqQ1cpmk User's guide to the video *******sparkleberrysprings****/innerlifeofcell.html Cells Are Like Robust Computational Systems, - June 2009 Excerpt: "We now have reason to think of cells as robust computational devices, employing redundancy in the same way that enables large computing systems, such as Amazon, to keep operating despite the fact that servers routinely fail." *******www.sciencedaily****/releases/2009/06/090616103205.htm Simulations reveal new information about the gateway to the cell nucleus Excerpt: “There are whole machines in living cells that are made of hundreds or thousands of proteins,” says Schulten, “and the nuclear pore is one of those systems. It’s actually one of the most magnificent systems in the cell.”,,,Hundreds to thousands of NPCs are embedded in the nuclear envelope of each cell,"... *******www.psc.edu/science/2006/schulten/ Primary Cilium As Cellular 'GPS System' Crucial To Wound Repair Excerpt: The primary cilium, the solitary, antenna-like structure that studs the outer surfaces of virtually all human cells, orient cells to move in the right direction and at the speed needed to heal wounds, much like a Global Positioning System helps ships navigate to their destinations. "What we are dealing with is a physiological analogy to the GPS system with a coupled autopilot that coordinates air traffic or tankers on open sea," *******www.sciencedaily****/releases/2008/12/081217190330.htm Intelligent Design - The Anthropic Hypothesis *******lettherebelight-77.blogspot****/
31 Mar 2010
1460
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6:47
Animators website: Virtual Cell Animation Collection *******vcell.ndsu.edu/animations/home.htm The Cell as a Collection of Protein Machines "We have always underestimated cells. Undoubtedly we still do today,,, Indeed, the entire cell can be viewed as a factory that contains an elaborate network of interlocking assembly lines, each which is composed of a set of large protein machines." Bruce Alberts: Former President, National Academy of Sciences; *******www.imbb.forth.gr/people/aeconomou/documents/Alberts98.pdf Molecular Machine - Nuclear Pore Complex - Stephen C. Meyer - video *******www.metacafe****/watch/4261990/ Simulations reveal new information about the gateway to the cell nucleus Excerpt: “There are whole machines in living cells that are made of hundreds or thousands of proteins,” says Schulten, “and the nuclear pore is one of those systems. It’s actually one of the most magnificent systems in the cell.”,,,Hundreds to thousands of NPCs are embedded in the nuclear envelope of each cell,"... *******www.psc.edu/science/2006/schulten/ Nuclear pore: Excerpt: Nuclear pores allow the transport of water-soluble molecules across the nuclear envelope. This transport includes RNA and ribosomes moving from nucleus to the cytoplasm and proteins (such as DNA polymerase and lamins), carbohydrates, signal molecules and lipids moving into the nucleus. It is notable that the nuclear pore complex (NPC) can actively conduct 1000 translocations per complex per second. *******en.wikipedia****/wiki/Nuclear_pore#Transport_through_the_nuclear_pore_complex The DNA Code - Solid Scientific Proof Of Intelligent Design - Perry Marshall - video *******www.metacafe****/watch/4060532 "A code system is always the result of a mental process (it requires an intelligent origin or inventor). It should be emphasized that matter as such is unable to generate any code. All experiences indicate that a thinking being voluntarily exercising his own free will, cognition, and creativity, is required. ,,,there is no known law of nature and no known sequence of events which can cause information to originate by itself in matter. Werner Gitt 1997 In The Beginning Was Information pp. 64-67, 79, 107." (The retired Dr Gitt was a director and professor at the German Federal Institute of Physics and Technology (Physikalisch-Technische Bundesanstalt, Braunschweig), the Head of the Department of Information Technology.) The coding system used for living beings is optimal from an engineering standpoint. Werner Gitt - In The Beginning Was Information - p. 95 Collective evolution and the genetic code - 2006: Excerpt: The genetic code could well be optimized to a greater extent than anything else in biology and yet is generally regarded as the biological element least capable of evolving. *******www.pnas****/content/103/28/10696.full Here, we show that the universal genetic code can efficiently carry arbitrary parallel codes much better than the vast majority of other possible genetic codes.... the present findings support the view that protein-coding regions can carry abundant parallel codes. *******genome.cshlp****/content/17/4/405.full The data compression of some stretches of human DNA is estimated to be up to 12 codes thick (12 different ways of DNA transcription) (Trifonov, 1989). (This is well beyond the complexity of any computer code ever written by man). John Sanford - Genetic Entropy Do you believe Richard Dawkins exists? Excerpt: DNA is the best information storage mechanism known to man. A single pinhead of DNA contains as much information as could be stored on 2 million two-terabyte hard drives. *******creation****/does-dawkins-exist Journey Inside The Cell (DNA to RNA to Protein)- Stephen Meyer - video *******www.youtube****/watch?v=1fiJupfbSpg BioVisions - The Inner Life of the Cell - video *******vimeo****/14691840 User's guide to the video *******sparkleberrysprings****/innerlifeofcell.html Honors to Researchers Who Probed Atomic Structure of Ribosomes - Robert F. Service Excerpt: "The ribosome’s dance, however, is more like a grand ballet, with dozens of ribosomal proteins and subunits pirouetting with every step while other key biomolecules leap in, carrying other dancers needed to complete the act.” *******www.creationsafaris****/crev200910.htm#20091015a The Ribosome: Perfectionist Protein-maker Trashes Errors Excerpt: The enzyme machine that translates a cell's DNA code into the proteins of life is nothing if not an editorial perfectionist...the ribosome exerts far tighter quality control than anyone ever suspected over its precious protein products... To their further surprise, the ribosome lets go of error-laden proteins 10,000 times faster than it would normally release error-free proteins, a rate of destruction that Green says is "shocking" and reveals just how much of a stickler the ribosome is about high-fidelity protein synthesis. *******www.sciencedaily****/releases/2009/01/090107134529.htm RNA: Protein Regulators Are Themselves Regulated “What was formerly conceived of as a direct, straightforward pathway is gradually turning out to be a dense network of regulatory mechanisms: genes are not simply translated into proteins via mRNA (messenger RNA). MicroRNAs control the translation of mRNAs (messenger RNAs) into proteins, and proteins in turn regulate the microRNAs at various levels.” *******www.sciencedaily****/releases/2009/09/090910084147.htm The Case Against a Darwinian Origin of Protein Folds - Douglas Axe - 2010 Excerpt Pg. 11: "Based on analysis of the genomes of 447 bacterial species, the projected number of different domain structures per species averages 991. Comparing this to the number of pathways by which metabolic processes are carried out, which is around 263 for E. coli, provides a rough figure of three or four new domain folds being needed, on average, for every new metabolic pathway. In order to accomplish this successfully, an evolutionary search would need to be capable of locating sequences that amount to anything from one in 10^159 to one in 10^308 possibilities, something the neo-Darwinian model falls short of by a very wide margin." *******bio-complexity****/ojs/index.php/main/article/view/BIO-C.2010.1 The Case Against a Darwinian Origin of Protein Folds - Douglas Axe, Jay Richards - audio *******intelligentdesign.podomatic****/player/web/2010-05-03T11_09_03-07_00 A Few Hundred Thousand Computers vs. A Single Protein Molecule - video *******www.metacafe****/watch/4018233 "The likelihood of developing two binding sites in a protein complex would be the square of the probability of developing one: a double CCC (chloroquine complexity cluster), 10^20 times 10^20, which is 10^40. There have likely been fewer than 10^40 cells in the entire world in the past 4 billion years, so the odds are against a single event of this variety (just 2 binding sites being generated by accident) in the history of life. It is biologically unreasonable." Michael J. Behe PhD. (from page 146 of his book "Edge of Evolution") Nature Paper,, Finds Darwinian Processes Lacking - Michael Behe - Oct. 2009 Excerpt: Now, thanks to the work of Bridgham et al (2009), even such apparently minor switches in structure and function (of a protein to its supposed ancestral form) are shown to be quite problematic. It seems Darwinian processes can’t manage to do even as much as I had thought. (which was 1 in 10^40 for just 2 binding sites) *******www.evolutionnews****/2009/10/nature_paper_finally_reaches_t.html Mitochondria - Molecular Machine - Powerhouse Of The Cell - video *******www.metacafe****/watch/5510941/ Evolution Vs ATP Synthase - Molecular Machine - video *******www.metacafe****/watch/4012706/ The Cell - A World Of Complexity Darwin Never Dreamed Of - Donald E. Johnson - video *******www.metacafe****/watch/4139390 Systems biology: Untangling the protein web - July 2009 Excerpt: Vidal thinks that technological improvements — especially in nanotechnology, to generate more data, and microscopy, to explore interaction inside cells, along with increased computer power — are required to push systems biology forward. "Combine all this and you can start to think that maybe some of the information flow can be captured," he says. But when it comes to figuring out the best way to explore information flow in cells, Tyers jokes that it is like comparing different degrees of infinity. "The interesting point coming out of all these studies is how complex these systems are — the different feedback loops and how they cross-regulate each other and adapt to perturbations are only just becoming apparent," he says. "The simple pathway models are a gross oversimplification of what is actually happening." *******www.nature****/nature/journal/v460/n7253/full/460415a.html 10 Ways Darwin Got It Wrong Excerpt: As molecular biologist Jonathan Wells and mathematician William Dembski point out: “It’s true that eukaryotic cells are the most complicated cells we know. But the simplest life forms we know, the prokaryotic cells (such as bacteria, which lack a nucleus), are themselves immensely complex.,,, There is no evidence whatsoever of earlier, more primitive life forms from which prokaryotes might have evolved” (How to Be an Intellectually Fulfilled Atheist (or Not), 2008, p. 4). These authors then mention what these two types of cells share in terms of complexity: • Information processing, storage and retrieval. • Artificial languages and their decoding systems. • Error detection, correction and proofreading devices for quality control. • Digital data-embedding technology. • Transportation and distribution systems. • Automated parcel addressing (similar to zip codes and UPS labels). • Assembly processes employing pre-fabrication and modular construction. • Self-reproducing robotic manufacturing plants. So it turns out that cells are far more complex and sophisticated than Darwin could have conceived of. How did mere chance produce this, when even human planning and engineering cannot? *******www.gnmagazine****/issues/gn85/10-ways-darwin-wrong.htm Quantum Mechanics at Work in Photosynthesis: Algae Familiar With These Processes for Nearly Two Billion Years - Feb. 2010 Excerpt: "We were astonished to find clear evidence of long-lived quantum mechanical states involved in moving the energy. Our result suggests that the energy of absorbed light resides in two places at once -- a quantum superposition state, or coherence -- and such a state lies at the heart of quantum mechanical theory.",,, "It suggests that algae knew about quantum mechanics nearly two billion years before humans," says Scholes. *******www.sciencedaily****/releases/2010/02/100203131356.htm Quantum Information/Entanglement In DNA & Protein Folding - short video *******www.metacafe****/watch/5936605/ Further evidence that quantum entanglement/information is found throughout entire protein structures: *******www.uncommondescent****/intelligent-design/rescue-proteins-leave-evolutionists-in-the-ditch/#comment-373214 It is very interesting to note that quantum entanglement, which conclusively demonstrates that ‘information’ is completely transcendent of any time and space constraints (Alain Aspect), should be found in molecular biology, for how can quantum entanglement, in molecular biology, possibly be explained by the materialistic framework of neo-Darwinism, a framework which is predicated on the presupposition of being constrained by time and space, when Alain Aspect and company falsified the validity of local realism (reductive materialism) in the first place with quantum entanglement? It is simply ludicrous to appeal to the materialistic framework, which undergirds the entire neo-Darwinian framework, that has been falsified by the very same quantum entanglement effect that one is seeking an explanation to! To give a coherent explanation for an effect that is shown to be completely independent of any time and space constraints one is forced to appeal to a cause that is itself not limited to time and space! Probability arguments, which have been a staple of the arguments against neo-Darwinism, simply do not apply! Further notes: The ‘Fourth Dimension’ Of Living Systems ********docs.google****/document/pub?id=1Gs_qvlM8-7bFwl9rZUB9vS6SZgLH17eOZdT4UbPoy0Y Astonishingly, actual motors, which far surpass man-made motors in 'engineering parameters', are now being found inside 'simple cells'. Articles and Videos on Molecular Motors/Machines *******docs.google****/Doc?docid=0AYmaSrBPNEmGZGM4ejY3d3pfMzlkNjYydmRkZw&hl=en Michael Behe - Life Reeks Of Design - 2010 - video *******www.metacafe****/watch/5066181 And in spite of the fact of finding molecular motors permeating the simplest of bacterial life, there are no detailed Darwinian accounts for the evolution of even one such motor or system. "There are no detailed Darwinian accounts for the evolution of any fundamental biochemical or cellular system only a variety of wishful speculations. It is remarkable that Darwinism is accepted as a satisfactory explanation of such a vast subject." James Shapiro - Molecular Biologist Intelligent Design - The Anthropic Hypothesis *******lettherebelight-77.blogspot****/2009/10/intelligent-design-anthropic-hypothesis_19.html
11 Mar 2011
1697
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6:05
The Cell - A World Of Complexity Darwin Never Dreamed Of - Donald E. Johnson - video *******www.metacafe****/watch/4139390 Articles and Videos on Molecular Motors *******docs.google****/Doc?docid=0AYmaSrBPNEmGZGM4ejY3d3pfMzlkNjYydmRkZw&hl=en Cells Are Like Robust Computational Systems, - June 2009 Excerpt: Gene regulatory networks in cell nuclei are similar to cloud computing networks, such as Google or Yahoo!, researchers report today in the online journal Molecular Systems Biology. The similarity is that each system keeps working despite the failure of individual components, whether they are master genes or computer processors. ,,,,"We now have reason to think of cells as robust computational devices, employing redundancy in the same way that enables large computing systems, such as Amazon, to keep operating despite the fact that servers routinely fail." *******www.sciencedaily****/releases/2009/06/090616103205.htm Systems biology: Untangling the protein web - July 2009 Excerpt: Vidal thinks that technological improvements — especially in nanotechnology, to generate more data, and microscopy, to explore interaction inside cells, along with increased computer power — are required to push systems biology forward. "Combine all this and you can start to think that maybe some of the information flow can be captured," he says. But when it comes to figuring out the best way to explore information flow in cells, Tyers jokes that it is like comparing different degrees of infinity. "The interesting point coming out of all these studies is how complex these systems are — the different feedback loops and how they cross-regulate each other and adapt to perturbations are only just becoming apparent," he says. "The simple pathway models are a gross oversimplification of what is actually happening." *******www.nature****/nature/journal/v460/n7253/full/460415a.html Three Subsets of Sequence Complexity and Their Relevance to Biopolymeric Information - David L. Abel and Jack T. Trevors - Theoretical Biology & Medical Modelling, Vol. 2, 11 August 2005, page 8 "No man-made program comes close to the technical brilliance of even Mycoplasmal genetic algorithms. Mycoplasmas are the simplest known organism with the smallest known genome, to date. How was its genome and other living organisms' genomes programmed?" *******www.biomedcentral****/content/pdf/1742-4682-2-29.pdf Simulations reveal new information about the gateway to the cell nucleus Excerpt: “There are whole machines in living cells that are made of hundreds or thousands of proteins,” says Schulten, “and the nuclear pore is one of those systems. It’s actually one of the most magnificent systems in the cell.”,,,Hundreds to thousands of NPCs are embedded in the nuclear envelope of each cell,"... *******www.psc.edu/science/2006/schulten/ Life Leads the Way to Invention - Feb. 2010 Excerpt: a cell is 10,000 times more energy-efficient than a transistor. “ In one second, a cell performs about 10 million energy-consuming chemical reactions, which altogether require about one picowatt (one millionth millionth of a watt) of power.” This and other amazing facts lead to an obvious conclusion: inventors ought to look to life for ideas.,,, Essentially, cells may be viewed as circuits that use molecules, ions, proteins and DNA instead of electrons and transistors. That analogy suggests that it should be possible to build electronic chips – what Sarpeshkar calls “cellular chemical computers” – that mimic chemical reactions very efficiently and on a very fast timescale. *******creationsafaris****/crev201002.htm#20100226a “Each cell with genetic information, from bacteria to man, consists of artificial languages and their decoding systems, memory banks for information storage and retrieval, elegant control systems regulating the automated assembly of parts and components, error fail-safe and proof-reading devices utilized for quality control, assembly processes involving the principle of prefabrication and modular construction and a capacity not equaled in any of our most advanced machines, for it would be capable of replicating its entire structure within a matter of a few hours" Geneticist Michael Denton PhD. Evolution: A Theory In Crisis pg. 329 "To grasp the reality of life as it has been revealed by molecular biology, we must first magnify a cell a thousand million times until it is 20 kilometers in diameter and resembles a giant airship large enough to cover a great city like London or New York. What we would see then would be an object of unparalleled complexity,...we would find ourselves in a world of supreme technology and bewildering complexity." Geneticist Michael Denton PhD., Evolution: A Theory In Crisis, pg.328 Michael Behe - Life Reeks Of Design - 2010 - video *******www.metacafe****/watch/5066181 And in spite of the fact of finding molecular motors permeating the simplest of bacterial life, there are no detailed Darwinian accounts for the evolution of even one such motor or system. "There are no detailed Darwinian accounts for the evolution of any fundamental biochemical or cellular system only a variety of wishful speculations. It is remarkable that Darwinism is accepted as a satisfactory explanation of such a vast subject. James Shapiro - Molecular Biologist The following expert doesn't even hide his very unscientific preconceived philosophical bias against intelligent design,,, ‘We should reject, as a matter of principle, the substitution of intelligent design for the dialogue of chance and necessity,,, Yet at the same time the same expert readily admits that neo-Darwinism has ZERO evidence for the chance and necessity of material processes producing any cellular system whatsoever,,, ,,,we must concede that there are presently no detailed Darwinian accounts of the evolution of any biochemical or cellular system, only a variety of wishful speculations.’ Franklin M. Harold,* 2001. The way of the cell: molecules, organisms and the order of life, Oxford University Press, New York, p. 205. *Professor Emeritus of Biochemistry, Colorado State University, USA Michael Behe - No Scientific Literature For Evolution of Any Irreducibly Complex Molecular Machines *******www.metacafe****/watch/5302950/ “The response I have received from repeating Behe's claim about the evolutionary literature, which simply brings out the point being made implicitly by many others, such as Chris Dutton and so on, is that I obviously have not read the right books. There are, I am sure, evolutionists who have described how the transitions in question could have occurred.” And he continues, “When I ask in which books I can find these discussions, however, I either get no answer or else some titles that, upon examination, do not, in fact, contain the promised accounts. That such accounts exist seems to be something that is widely known, but I have yet to encounter anyone who knows where they exist.” David Ray Griffin - retired professor of philosophy of religion and theology Doug Axe Knows His Work Better Than Steve Matheson Excerpt: Regardless of how the trials are performed, the answer ends up being at least half of the total number of password possibilities, which is the staggering figure of 10^77 (written out as 100, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000). Armed with this calculation, you should be very confident in your skepticism, because a 1 in 10^77 chance of success is, for all practical purposes, no chance of success. My experimentally based estimate of the rarity of functional proteins produced that same figure, making these likewise apparently beyond the reach of chance. *******www.evolutionnews****/2010/06/doug_axe_knows_his_work_better035561.html Evolution vs. Functional Proteins - Doug Axe - Video *******www.metacafe****/watch/4018222 Intelligent Design - The Anthropic Hypothesis *******lettherebelight-77.blogspot****/2009/10/intelligent-design-anthropic-hypothesis_19.html
31 Jul 2011
1310
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9:12
Here Is the entire video: The Return of the God Hypothesis - Stephen Meyer - video: *******www.watermarkradio****/index.php?id=153&channel=237&series=140&message=0 Article: *******www.arn****/docs/meyer/sm_returnofgod.pdf Here is a site where you can order Dr. Meyer's book: SIGNATURE IN THE CELL by Stephen C. Meyer *******www.signatureinthecell****/ Journey Inside The Cell - DNA to mRNA to Proteins - Stephen Meyer - Signature In The Cell - video *******www.youtube****/watch?v=1fiJupfbSpg Evolution vs ATP Synthase - Molecular Machine - video *******www.metacafe****/watch/4012706/evolution_vs_atp_synthase_molecular_machine/ "There are no detailed Darwinian accounts for the evolution of any fundamental biochemical or cellular system only a variety of wishful speculations. It is remarkable that Darwinism is accepted as a satisfactory explanation of such a vast subject." James Shapiro - Molecular Biologist Virus - Assembly Of A Nano-Machine - video *******www.metacafe****/watch/4023122/the_virus_assembly_of_a_molecular_machine_intelligent_design/ Bacterial Flagellum - A Sheer Wonder Of Intelligent Design - video *******www.metacafe****/watch/3994630/bacterial_flagellum_a_sheer_wonder_of_intelligent_design/ Michael Behe on Falsifying Intelligent Design - video *******www.youtube****/watch?v=N8jXXJN4o_A Richard Dawkins - EXPELLED - The UFO Interview - video *******www.youtube****/watch?v=GlZtEjtlirc Mathematically Defining Functional Information In Molecular Biology - Kirk Durston - short video *******www.metacafe****/watch/3995236/mathematically_defining_functional_information_in_molecular_biology_kirk_durston/ Entire video: *******vimeo****/1775160 William Bialek - Professor Of Physics - Princeton University: Excerpt: "A central theme in my research is an appreciation for how well things “work” in biological systems. It is, after all, some notion of functional behavior that distinguishes life from inanimate matter, and it is a challenge to quantify this functionality in a language that parallels our characterization of other physical systems. Strikingly, when we do this (and there are not so many cases where it has been done!), the performance of biological systems often approaches some limits set by basic physical principles. While it is popular to view biological mechanisms as an historical record of evolutionary and developmental compromises, these observations on functional performance point toward a very different view of life as having selected a set of near optimal mechanisms for its most crucial tasks." *******www.princeton.edu/~wbialek/wbialek.html Ben Stein - EXPELLED - The Complexity of the Cell - video *******www.metacafe****/watch/4018253/expelled_complexity_of_the_cell/ Intelligent Design - The Anthropic Hypothesis *******lettherebelight-77.blogspot****/
16 Apr 2010
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8:40
"There are no detailed Darwinian accounts for the evolution of any fundamental biochemical or cellular system only a variety of wishful speculations. It is remarkable that Darwinism is accepted as a satisfactory explanation of such a vast subject." James Shapiro - Molecular Biologist The Cell as a Collection of Protein Machines "We have always underestimated cells. Undoubtedly we still do today,,, Indeed, the entire cell can be viewed as a factory that contains an elaborate network of interlocking assembly lines, each which is composed of a set of large protein machines." Bruce Alberts: Former President, National Academy of Sciences; *******www.imbb.forth.gr/people/aeconomou/documents/Alberts98.pdf Stephen Meyer - Functional Proteins And Information For Body Plans - video *******www.metacafe****/watch/4050681/stephen_meyer_functional_proteins_and_information_for_body_plans/ CELL TO VIRUS - SIZE AND SCALE - Move Cursor At Bottom Of Graph To Zoom In *******learn.genetics.utah.edu/content/begin/cells/scale/ The Virus - Assembly Of A Molecular Machine - Intelligent Design *******www.metacafe****/watch/4023122/the_virus_assembly_of_a_molecular_machine_intelligent_design/ Bacterial Flagellum - A Sheer Wonder Of Intelligent Design - video *******www.metacafe****/watch/3994630/bacterial_flagellum_a_sheer_wonder_of_intelligent_design/ Evolution vs ATP Synthase - Molecular Machine - video *******www.metacafe****/watch/4012706/evolution_vs_atp_synthase_molecular_machine/ Stephen Meyer - Molecular Machines & Information *******www.metacafe****/watch/4146691/stephen_meyer_molecular_machines_information/ Kinesin Transport Protein - video *******www.youtube****/watch?v=4TGDPotbJV4 The Cell as a Collection of Protein Machines "We have always underestimated cells. Undoubtedly we still do today,,, Indeed, the entire cell can be viewed as a factory that contains an elaborate network of interlocking assembly lines, each which is composed of a set of large protein machines." Bruce Alberts: Former President, National Academy of Sciences; *******www.imbb.forth.gr/people/aeconomou/documents/Alberts98.pdf The inner life of a cell - Harvard University - video *******www.youtube****/watch?v=BtZEqQ1cpmk User's guide to the video *******sparkleberrysprings****/innerlifeofcell.html Journey Inside The Cell - DNA to mRNA to Proteins - Stephen Meyer - Signature In The Cell - video *******www.youtube****/watch?v=1fiJupfbSpg Map Of Major Metabolic Pathways In A Cell - Diagram ********webspace.utexas.edu/yg387/MetabolicPathway.jpg Intelligent Design - The Anthropic Hypothesis *******lettherebelight-77.blogspot****/
11 Apr 2011
6335
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2:09
An enormous gap exists between prokaryote (bacteria and cyanobacteria) cells and eukaryote (protists, plants and animals) type of cells: Excerpt: A crucial difference between prokaryotes and eukaryotes is the means they use to produce ATP. All life produces ATP by three basic chemical methods only: oxidative phosphorylation, photophosphorylation, and substrate-level phosphorylation (Lim, 1998, p. 149). In prokaryotes ATP is produced both in the cell wall and in the cytosol by glycolysis. In eukaryotes most ATP is produced in chloroplasts (for plants), or in mitochondria (for both plants and animals). No means of producing ATP exists that is intermediate between these four basic methods and no transitional forms have ever been found that bridge the gap between these four different forms of ATP production. The machinery required to manufacture ATP is so intricate that viruses are not able to make their own ATP. They require cells to manufacture it and viruses have no source of energy apart from cells. ...prokaryotes and eukaryotes are profoundly different from each other and clearly represent a marked dichotomy in the 'evolution' of life. . . The organizational complexity of the eukaryotes is so much greater than that of the prokaryotes that it is difficult to visualize how a eukaryote could have arisen from any known prokaryote (Hickman et al., 1997, p. 39). Some of the differences are that prokaryotes lack organelles, a cytoskeleton, and most of the other structures present in eukaryotic cells. Consequently, the functions of most organelles and other ultrastructure cell parts must be performed in bacteria by the cell membrane and its infoldings called mesosomes. *******www.trueorigin****/atp.asp The Darwinian Basis of the Prokaryote-to-Eukaryote Transition Collapses - Nov. 2010 *******www.evolutionnews****/2010/11/on_the_energetics_of_genome_co040431.html Evolution vs ATP Synthase - Molecular Machine - video *******www.metacafe****/watch/4012706 The ATP Synthase Enzyme - exquisite motor necessary for first life - video *******www.youtube****/watch?v=W3KxU63gcF4 The inner life of a cell - Harvard University - video *******www.youtube****/watch?v=mbcWGU8fpxA User's guide to the video *******sparkleberrysprings****/innerlifeofcell.html The Cell - A World Of Complexity Darwin Never Dreamed Of - Donald E. Johnson - video *******www.metacafe****/watch/4139390 Ben Stein - EXPELLED - The Staggering Complexity Of The Cell - video *******www.metacafe****/watch/4227700 Articles and Videos on Molecular Motors *******docs.google****/Doc?docid=0AYmaSrBPNEmGZGM4ejY3d3pfMzlkNjYydmRkZw&hl=en Michael Behe - Life Reeks Of Design - 2010 - video *******www.metacafe****/watch/5066181 Stephen Meyer - Functional Proteins And Information For Body Plans - video *******www.metacafe****/watch/4050681 Intelligent Design - The Anthropic Hypothesis *******lettherebelight-77.blogspot****/2009/10/intelligent-design-anthropic-hypothesis_19.html
18 Nov 2010
2250
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8:42
Best Look Ever at Lifes Smallest Rotary Motor - article Excerpt: They imaged 19,825 motors to increase the average resolution down to 1.6 Angstroms (16 nanometers, or billionths of a meter). As a result, they were able to map out all the parts in better detail than ever, which are shown in photographs and diagrams in the paper. *******www.creationsafaris****/crev201001.htm#20100107c "There are no detailed Darwinian accounts for the evolution of any fundamental biochemical or cellular system only a variety of wishful speculations. It is remarkable that Darwinism is accepted as a satisfactory explanation of such a vast subject." James Shapiro - Molecular Biologist ATP Synthase achieves nearly 100% efficiency which far surpasses any human engineered motor: A rotary molecular motor that can work at near 100% efficiency: Excerpt: In cells, the free energy of ATP hydrolysis is ca. 90 pN nm per ATP molecule, suggesting that the F1 motor can work at near 100% efficiency. We confirmed in vitro that F1 indeed does ca. 80 pN nm of work under the condition where the free energy per ATP is 90 pN nm. The high efficiency may be related to the fully reversible nature of the F1 motor: *******rstb.royalsocietypublishing****/content/355/1396/473.abstract Worlds Smallest Rotary Engine Highlighted Excerpt: The match implies 100% efficiency for the conversion of the Gibbs free energy of ATP hydrolysis into mechanical work performed on the elastically strained filament. This is not surprising given the approximate thermodynamic equilibrium of the enzyme (long)-filament construct. *******www.creationsafaris****/crev200905.htm#20090525a ATP: The Perfect Energy Currency for the Cell Jerry Bergman, Ph.D. *******www.trueorigin****/atp.asp Excerpt: Without ATP, life as we understand it could not exist. It is a perfectly-designed, intricate molecule that serves a critical role in providing the proper size energy packet for scores of thousands of classes of reactions that occur in all forms of life. Even viruses rely on an ATP molecule identical to that used in humans. The ATP energy system is quick, highly efficient, produces a rapid turnover of ATP, and can rapidly respond to energy demand changes (Goodsell, 1996, p.79). Furthermore, the ATP molecule is so enormously intricate that we are just now beginning to understand how it works. Each ATP molecule is over 500 atomic mass units (500 AMUs). In manufacturing terms, the ATP molecule is a machine with a level of organization on the order of a research microscope or a standard television (Darnell, Lodish, and Baltimore, 1996). Among the questions evolutionists must answer include the following, 'How did life exist before ATP?' 'How could life survive without ATP since no form of life we know of today can do that?' and 'How could ATP evolve and where are the many transitional forms required to evolve the complex ATP molecule?' No feasible candidates exist and none can exist because only a perfect ATP molecule can properly carry out its role in the cell. In addition, a potential ATP candidate molecule would not be selected for by evolution until it was functional and life could not exist without ATP or a similar molecule that would have the same function. ATP is an example of a molecule that displays irreducible complexity which cannot be simplified and still function (Behe, 1996). ATP could have been created only as a unit to function immediately in life and the same is true of the other intricate energy molecules used in life such as GTP. Although other energy molecules can be used for certain cell functions, none can even come close to satisfactorily replacing all the many functions of ATP. Over 100,000 other detailed molecules like ATP have also been designed to enable humans to live, and all the same problems related to their origin exist for them all. Many macromolecules that have greater detail than ATP exist, as do a few that are less highly organized, and in order for life to exist all of them must work together as a unit. Intelligent Design - The Anthropic Hypothesis *******lettherebelight-77.blogspot****/ Three subsets of sequence complexity and their relevance to biopolymeric information: Excerpt: We repeat that a single incident of nontrivial algorithmic programming success achieved without selection for fitness at the decision-node programming level would falsify any of these null hypotheses. This renders each of these hypotheses scientifically testable. We offer the prediction that none of these four hypotheses will be falsified. *******www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1208958
1 Oct 2010
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5:31
The first thought I had when I saw the bacteriophage virus is that it looks similar to the lunar lander of the Apollo program. The comparison is not without merit considering some of the relative distances to be traveled and the virus must somehow possess, as of yet unelucidated, orientation, guidance, docking, unloading, loading, etc... mechanisms. And please remember this level of complexity exists in a world that is far too small to be seen with the naked eye. This excellent video gives a small glimpse at the intricate, and humbling, complexity that goes into crafting the "simple" non-living bacteriophage virus. For anyone who has a molecular biology project they would like to bring to life with such stunning animation, please contact: Seyet LLC - Life Science Animation | Visual Communication Company *******www.seyet****/ "There are no detailed Darwinian accounts for the evolution of any fundamental biochemical or cellular system only a variety of wishful speculations. It is remarkable that Darwinism is accepted as a satisfactory explanation of such a vast subject." James Shapiro - Molecular Biologist CELL TO VIRUS - SIZE AND SCALE - Move Cursor At Bottom Of Graph To Zoom In *******learn.genetics.utah.edu/content/begin/cells/scale/ The Capabilities of Chaos and Complexity: David L. Abel - Null Hypothesis For Information Generation - 2009 To focus the scientific communitys attention on its own tendencies toward overzealous metaphysical imagination bordering on wish-fulfillment, we propose the following readily falsifiable null hypothesis, and invite rigorous experimental attempts to falsify it: "Physicodynamics cannot spontaneously traverse The Cybernetic Cut: physicodynamics alone cannot organize itself into formally functional systems requiring algorithmic optimization, computational halting, and circuit integration." A single exception of non trivial, unaided spontaneous optimization of formal function by truly natural process would falsify this null hypothesis. *******www.mdpi****/1422-0067/10/1/247/pdf *******mdpi****/1422-0067/10/1/247/ag Intelligent Design - The Anthropic Hypothesis *******lettherebelight-77.blogspot****/
20 Jan 2010
7633
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7:37
Genetic Entropy Refutation of Nick Matzke's TTSS (type III secretion system) to Flagellum Evolutionary Narrative: excerpt: .....Comparative genomic analysis show that flagellar genes have been differentially lost in endosymbiotic bacteria of insects. Only proteins involved in protein export within the flagella assembly pathway (type III secretion system and the basal-body) have been kept... *******mbe.oxfordjournals****/cgi/content/abstract/msn153v1 "One fact in favour of the flagellum-first view is that bacteria would have needed propulsion before they needed T3SSs, which are used to attack cells that evolved later than bacteria. Also, flagella are found in a more diverse range of bacterial species than T3SSs. The most parsimonious explanation is that the T3SS arose later," Howard Ochman - Biochemist - New Scientist (Feb 16, 2008) Michael Behe on Falsifying Intelligent Design - video *******www.youtube****/watch?v=N8jXXJN4o_A Bacterial Flagella - A Paradigm for Design - Scott Minnich - video *******www.youtube****/watch?v=N949Ysm0KTY *******www.veritas****/media/talks/92 *******www.nanonet.go.jp/english/mailmag/2004/011a.html *******video.google.it/videoplay?docid=-2771020846872851325 Functional Diagram e-coli *******www.veritas-ucsb****/library/origins/IMAGES/1.gif Genetic analysis of coordinate flagellar and type III - Minnich and Meyer Molecular machines display a key signature or hallmark of design, namely, irreducible complexity. In all irreducibly complex systems in which the cause of the system is known by experience or observation, intelligent design or engineering played a role the origin of the system. *******www.discovery****/scripts/viewDB/filesDB-download.php?id=389 Flagellum - Sean D. Pitman, M.D. *******www.detectingdesign****/flagellum.html The Capabilities of Chaos and Complexity: David L. Abel - Null Hypothesis For Information Generation - 2009 To focus the scientific communitys attention on its own tendencies toward overzealous metaphysical imagination bordering on wish-fulfillment, we propose the following readily falsifiable null hypothesis, and invite rigorous experimental attempts to falsify it: Physicodynamics cannot spontaneously traverse The Cybernetic Cut: physicodynamics alone cannot organize itself into formally functional systems requiring algorithmic optimization, computational halting, and circuit integration. *******www.mdpi****/1422-0067/10/1/247/pdf *******mdpi****/1422-0067/10/1/247/ag Proteins Are Extremely Rare - Doug Axe - Video *******www.youtube****/watch?v=h38Xi-Jz9yk Virus - Assembly Of A Nano-Machine - video *******www.youtube****/watch?v=Ofd_lgEymto "There are no detailed Darwinian accounts for the evolution of any fundamental biochemical or cellular system only a variety of wishful speculations. It is remarkable that Darwinism is accepted as a satisfactory explanation of such a vast subject." James Shapiro - Molecular Biologist Intelligent Design - The Anthropic Hypothesis *******lettherebelight-77.blogspot****/
27 Jun 2011
9554
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