Results for: molecular machine Search Results
Family Filter:
9:12
Here Is the entire video: The Return of the God Hypothesis - Stephen Meyer - video: http://www.watermarkradio.com/index.php?id=153&channel=237&series=140&message=0 Article: http://www.arn.org/docs/meyer/sm_returnofgod.pdf Here is a site where you can order Dr. Meyer's book: SIGNATURE IN THE CELL by Stephen C. Meyer http://www.signatureinthecell.com/ Journey Inside The Cell - DNA to mRNA to Proteins - Stephen Meyer - Signature In The Cell - video http://www.youtube.com/watch?v=1fiJupfbSpg Evolution vs ATP Synthase - Molecular Machine - video http://www.metacafe.com/watch/4012706/evolution_vs_atp_synthase_molecular_machine/ "There are no detailed Darwinian accounts for the evolution of any fundamental biochemical or cellular system only a variety of wishful speculations. It is remarkable that Darwinism is accepted as a satisfactory explanation of such a vast subject." James Shapiro - Molecular Biologist Virus - Assembly Of A Nano-Machine - video http://www.metacafe.com/watch/4023122/the_virus_assembly_of_a_molecular_machine_intelligent_design/ Bacterial Flagellum - A Sheer Wonder Of Intelligent Design - video http://www.metacafe.com/watch/3994630/bacterial_flagellum_a_sheer_wonder_of_intelligent_design/ Michael Behe on Falsifying Intelligent Design - video http://www.youtube.com/watch?v=N8jXXJN4o_A Richard Dawkins - EXPELLED - The UFO Interview - video http://www.youtube.com/watch?v=GlZtEjtlirc Mathematically Defining Functional Information In Molecular Biology - Kirk Durston - short video http://www.metacafe.com/watch/3995236/mathematically_defining_functional_information_in_molecular_biology_kirk_durston/ Entire video: http://vimeo.com/1775160 William Bialek - Professor Of Physics - Princeton University: Excerpt: "A central theme in my research is an appreciation for how well things “work” in biological systems. It is, after all, some notion of functional behavior that distinguishes life from inanimate matter, and it is a challenge to quantify this functionality in a language that parallels our characterization of other physical systems. Strikingly, when we do this (and there are not so many cases where it has been done!), the performance of biological systems often approaches some limits set by basic physical principles. While it is popular to view biological mechanisms as an historical record of evolutionary and developmental compromises, these observations on functional performance point toward a very different view of life as having selected a set of near optimal mechanisms for its most crucial tasks." http://www.princeton.edu/~wbialek/wbialek.html Ben Stein - EXPELLED - The Complexity of the Cell - video http://www.metacafe.com/watch/4018253/expelled_complexity_of_the_cell/ Intelligent Design - The Anthropic Hypothesis http://lettherebelight-77.blogspot.com/
16 Apr 2010
5499
Share Video

8:40
"There are no detailed Darwinian accounts for the evolution of any fundamental biochemical or cellular system only a variety of wishful speculations. It is remarkable that Darwinism is accepted as a satisfactory explanation of such a vast subject." James Shapiro - Molecular Biologist The Cell as a Collection of Protein Machines "We have always underestimated cells. Undoubtedly we still do today,,, Indeed, the entire cell can be viewed as a factory that contains an elaborate network of interlocking assembly lines, each which is composed of a set of large protein machines." Bruce Alberts: Former President, National Academy of Sciences; http://www.imbb.forth.gr/people/aeconomou/documents/Alberts98.pdf Stephen Meyer - Functional Proteins And Information For Body Plans - video http://www.metacafe.com/watch/4050681/stephen_meyer_functional_proteins_and_information_for_body_plans/ CELL TO VIRUS - SIZE AND SCALE - Move Cursor At Bottom Of Graph To Zoom In http://learn.genetics.utah.edu/content/begin/cells/scale/ The Virus - Assembly Of A Molecular Machine - Intelligent Design http://www.metacafe.com/watch/4023122/the_virus_assembly_of_a_molecular_machine_intelligent_design/ Bacterial Flagellum - A Sheer Wonder Of Intelligent Design - video http://www.metacafe.com/watch/3994630/bacterial_flagellum_a_sheer_wonder_of_intelligent_design/ Evolution vs ATP Synthase - Molecular Machine - video http://www.metacafe.com/watch/4012706/evolution_vs_atp_synthase_molecular_machine/ Stephen Meyer - Molecular Machines & Information http://www.metacafe.com/watch/4146691/stephen_meyer_molecular_machines_information/ Kinesin Transport Protein - video http://www.youtube.com/watch?v=4TGDPotbJV4 The Cell as a Collection of Protein Machines "We have always underestimated cells. Undoubtedly we still do today,,, Indeed, the entire cell can be viewed as a factory that contains an elaborate network of interlocking assembly lines, each which is composed of a set of large protein machines." Bruce Alberts: Former President, National Academy of Sciences; http://www.imbb.forth.gr/people/aeconomou/documents/Alberts98.pdf The inner life of a cell - Harvard University - video http://www.youtube.com/watch?v=BtZEqQ1cpmk User's guide to the video http://sparkleberrysprings.com/innerlifeofcell.html Journey Inside The Cell - DNA to mRNA to Proteins - Stephen Meyer - Signature In The Cell - video http://www.youtube.com/watch?v=1fiJupfbSpg Map Of Major Metabolic Pathways In A Cell - Diagram https://webspace.utexas.edu/yg387/MetabolicPathway.jpg Intelligent Design - The Anthropic Hypothesis http://lettherebelight-77.blogspot.com/
11 Apr 2011
5766
Share Video

2:21
Translational machinery, which makes proteins in all cells using instructions encoded in the gene. This process involves the ribosome and its interaction with mRNA, tRNA and various protein factors. This video is from the lab of Venkataraman Ramakrishnan who was Joint-winner of 2009 Nobel Prize for Chemistry. For his work on a neutron-scattering map of the RNA of ribosomes, the protein-making structures in cells. - http://indiaunfinished.wordpress.com/2009/10/07/venkataraman-ramakrishnan/ Here is his lab page: Ribosome Structure and Function http://www.mrc-lmb.cam.ac.uk/ribo/homepage/index.html Ramakrishnan described his work on ribosomes as an attempt to understand “this large molecular machine that takes information from genes and uses it to stitch together protein.” He said he and others had been using X-ray crystallography to build an “atomic picture of this enormous machine.” for a bit more detail on what is happening in the featured video check out these following videos: Journey Inside The Cell - video http://www.journeyinsidethecell.com/ Stephen Meyer - Functional Proteins And Information For Body Plans - video http://www.metacafe.com/watch/4050681/stephen_meyer_functional_proteins_and_information_for_body_plans/ Intelligent Design - The Anthropic Hypothesis http://lettherebelight-77.blogspot.com/
9 Sep 2011
6334
Share Video

1:27
Simulations reveal new information about the gateway to the cell nucleus Excerpt: “There are whole machines in living cells that are made of hundreds or thousands of proteins,” says Schulten, “and the nuclear pore is one of those systems. It’s actually one of the most magnificent systems in the cell.”,,,Hundreds to thousands of NPCs are embedded in the nuclear envelope of each cell,"... http://www.psc.edu/science/2006/schulten/ Nuclear pore: Excerpt: Nuclear pores allow the transport of water-soluble molecules across the nuclear envelope. This transport includes RNA and ribosomes moving from nucleus to the cytoplasm and proteins (such as DNA polymerase and lamins), carbohydrates, signal molecules and lipids moving into the nucleus. It is notable that the nuclear pore complex (NPC) can actively conduct 1000 translocations per complex per second. http://en.wikipedia.org/wiki/Nuclear_pore#Transport_through_the_nuclear_pore_complex The Nuclear Pore Complex - Gateway to the Nucleus Excerpt: The nuclear pore complex (NPC), perhaps the largest protein complex in the cell, is responsible for the protected exchange of components between the nucleus and cytoplasm and for preventing the transport of material not destined to cross the nuclear envelope. http://www.ks.uiuc.edu/Research/npc/ The nuclear pore complex becomes alive: new insights into its dynamics and involvement in different cellular processes Excerpt: In this review we summarize the structure and function of the nuclear pore complex (NPC). Special emphasis is put on recent findings which reveal the NPC as a dynamic structure in the context of cellular events like nucleocytoplasmic transport, cell division and differentiation, stress response and apoptosis. Evidence for the involvement of nucleoporins in transcription and oncogenesis is discussed,,, http://atlasgeneticsoncology.org/Deep/NuclearPoreComplID20048.html The Cell as a Collection of Protein Machines "We have always underestimated cells. Undoubtedly we still do today,,, Indeed, the entire cell can be viewed as a factory that contains an elaborate network of interlocking assembly lines, each which is composed of a set of large protein machines." Bruce Alberts: Former President, National Academy of Sciences; http://www.imbb.forth.gr/people/aeconomou/documents/Alberts98.pdf Bacterial Flagellum - A Sheer Wonder Of Intelligent Design - video http://www.metacafe.com/watch/3994630/bacterial_flagellum_a_sheer_wonder_of_intelligent_design/ Stephen Meyer - Molecular Machines & Information http://www.metacafe.com/watch/4146691/stephen_meyer_molecular_machines_information/ The Virus - Assembly Of A Molecular Machine - video http://www.metacafe.com/watch/4023122/the_virus_assembly_of_a_molecular_machine_intelligent_design/ The Virus - A Molecular Lunar Landing Machine - video http://www.metacafe.com/watch/4205494/the_virus_a_molecular_lunar_landing_machine/ Evolution vs ATP Synthase - Molecular Machine - video http://www.metacafe.com/watch/4012706/evolution_vs_atp_synthase_molecular_machine/ Molecular Highway Motor Comes info Focus Excerpt: “kinesin proteins motor along microtubules like trains on a railroad track, towing cargo to various locations within cells and assisting in cell division.” Each rocking motion of the see-saw requires energy from ATP. http://www.creationsafaris.com/crev201002.htm#20100219a Kinesin Transport Protein - video http://www.youtube.com/watch?v=4TGDPotbJV4 Michael Behe - Lee Strobel - Molecular Machines http://www.metacafe.com/watch/4209383/michael_behe_lee_strobel_molecular_machines/ Stephen Meyer - Functional Proteins And Information For Body Plans - video http://www.metacafe.com/watch/4050681/stephen_meyer_functional_proteins_and_information_for_body_plans/ Intelligent Design - The Anthropic Hypothesis http://lettherebelight-77.blogspot.com/
10 Mar 2010
15248
Share Video

9:41
Molecular Machine Bacterial Flagella - A Paradigm For Intelligent Design - Scott Minnich - entire video http://www.vimeo.com/9032112 Scott Minnich homepage: http://www.cals.uidaho.edu/mmbb/minnich.asp The best known example for irreducible complexity, and thus for Intelligent Design, in molecular biology has become the bacterial flagellum. Bacterial Flagellum - A Sheer Wonder Of Intelligent Design - video http://www.metacafe.com/watch/3994630/bacterial_flagellum_a_sheer_wonder_of_intelligent_design/ Biologist Howard Berg at Harvard calls the Bacterial Flagellum “the most efficient machine in the universe." The flagellum has steadfastly resisted all attempts to elucidate its plausible origination by Darwinian processes, much less has anyone ever actually evolved a flagellum from scratch in the laboratory; Genetic Entropy Refutation of Nick Matzke's TTSS (type III secretion system) to Flagellum Evolutionary Narrative: Excerpt: Comparative genomic analysis show that flagellar genes have been differentially lost in endosymbiotic bacteria of insects. Only proteins involved in protein export within the flagella assembly pathway (type III secretion system and the basal-body) have been kept... http://mbe.oxfordjournals.org/cgi/content/abstract/msn153v1 "One fact in favour of the flagellum-first view is that bacteria would have needed propulsion before they needed T3SSs, which are used to attack cells that evolved later than bacteria. Also, flagella are found in a more diverse range of bacterial species than T3SSs. ‘The most parsimonious explanation is that the T3SS arose later," Howard Ochman - Biochemist - New Scientist (Feb 16, 2008) Michael Behe on Falsifying Intelligent Design - video http://www.youtube.com/watch?v
7 Mar 2010
1148
Share Video

1:21
Evolution Vs ATP Synthase - Molecular Machine - video http://www.metacafe.com/watch/4012706 Evolution Vs. Functional Proteins - Where Did The Information Come From? - Doug Axe - Stephen Meyer - video http://www.metacafe.com/watch/4018222 "There are no detailed Darwinian accounts for the evolution of any fundamental biochemical or cellular system only a variety of wishful speculations. It is remarkable that Darwinism is accepted as a satisfactory explanation of such a vast subject." James Shapiro - Molecular Biologist ATP Synthase achieves nearly 100% efficiency which far surpasses any human engineered motor: A rotary molecular motor that can work at near 100% efficiency: Excerpt: In cells, the free energy of ATP hydrolysis is ca. 90 pN nm per ATP molecule, suggesting that the F1 motor can work at near 100% efficiency. We confirmed in vitro that F1 indeed does ca. 80 pN nm of work under the condition where the free energy per ATP is 90 pN nm. The high efficiency may be related to the fully reversible nature of the F1 motor: http://rstb.royalsocietypublishing.org/content/355/1396/473.abstract Worlds Smallest Rotary Engine Highlighted Excerpt: The match implies 100% efficiency for the conversion of the Gibbs free energy of ATP hydrolysis into mechanical work performed on the elastically strained filament. This is not surprising given the approximate thermodynamic equilibrium of the enzyme (long)-filament construct. http://www.creationsafaris.com/crev200905.htm#20090525a ATP: The Perfect Energy Currency for the Cell Jerry Bergman, Ph.D. http://www.trueorigin.org/atp.asp Astonishingly, and to the dismay of atheistic evolutionists, actual motors, which far surpass man-made motors in 'engineering parameters', are now being found inside 'simple cells'. Articles and Videos on Molecular Motors http://docs.google.com/Doc?docid=0AYmaSrBPNEmGZGM4ejY3d3pfMzlkNjYydmRkZw&hl=en Bacterial Flagellum - A Sheer Wonder Of Intelligent Design - video http://www.metacafe.com/watch/3994630 Biologist Howard Berg at Harvard calls the Bacterial Flagellum “the most efficient machine in the universe." Michael Behe on Falsifying Intelligent Design - video http://www.youtube.com/watch?v=N8jXXJN4o_A The Cell as a Collection of Protein Machines "We have always underestimated cells. Undoubtedly we still do today,,, Indeed, the entire cell can be viewed as a factory that contains an elaborate network of interlocking assembly lines, each which is composed of a set of large protein machines." Bruce Alberts: Former President, National Academy of Sciences; http://www.imbb.forth.gr/people/aeconomou/documents/Alberts98.pdf The Cell - A World Of Complexity Darwin Never Dreamed Of - Donald E. Johnson - video http://www.metacafe.com/watch/4139390 The inner life of a cell - Harvard University - video http://www.youtube.com/watch?v=BtZEqQ1cpmk User's guide to the video http://sparkleberrysprings.com/innerlifeofcell.html Cells Are Like Robust Computational Systems, - June 2009 Excerpt: "We now have reason to think of cells as robust computational devices, employing redundancy in the same way that enables large computing systems, such as Amazon, to keep operating despite the fact that servers routinely fail." http://www.sciencedaily.com/releases/2009/06/090616103205.htm Simulations reveal new information about the gateway to the cell nucleus Excerpt: “There are whole machines in living cells that are made of hundreds or thousands of proteins,” says Schulten, “and the nuclear pore is one of those systems. It’s actually one of the most magnificent systems in the cell.”,,,Hundreds to thousands of NPCs are embedded in the nuclear envelope of each cell,"... http://www.psc.edu/science/2006/schulten/ Primary Cilium As Cellular 'GPS System' Crucial To Wound Repair Excerpt: The primary cilium, the solitary, antenna-like structure that studs the outer surfaces of virtually all human cells, orient cells to move in the right direction and at the speed needed to heal wounds, much like a Global Positioning System helps ships navigate to their destinations. "What we are dealing with is a physiological analogy to the GPS system with a coupled autopilot that coordinates air traffic or tankers on open sea," http://www.sciencedaily.com/releases/2008/12/081217190330.htm Intelligent Design - The Anthropic Hypothesis http://lettherebelight-77.blogspot.com/
31 Mar 2010
1250
Share Video

2:09
An enormous gap exists between prokaryote (bacteria and cyanobacteria) cells and eukaryote (protists, plants and animals) type of cells: Excerpt: A crucial difference between prokaryotes and eukaryotes is the means they use to produce ATP. All life produces ATP by three basic chemical methods only: oxidative phosphorylation, photophosphorylation, and substrate-level phosphorylation (Lim, 1998, p. 149). In prokaryotes ATP is produced both in the cell wall and in the cytosol by glycolysis. In eukaryotes most ATP is produced in chloroplasts (for plants), or in mitochondria (for both plants and animals). No means of producing ATP exists that is intermediate between these four basic methods and no transitional forms have ever been found that bridge the gap between these four different forms of ATP production. The machinery required to manufacture ATP is so intricate that viruses are not able to make their own ATP. They require cells to manufacture it and viruses have no source of energy apart from cells. ...prokaryotes and eukaryotes are profoundly different from each other and clearly represent a marked dichotomy in the 'evolution' of life. . . The organizational complexity of the eukaryotes is so much greater than that of the prokaryotes that it is difficult to visualize how a eukaryote could have arisen from any known prokaryote (Hickman et al., 1997, p. 39). Some of the differences are that prokaryotes lack organelles, a cytoskeleton, and most of the other structures present in eukaryotic cells. Consequently, the functions of most organelles and other ultrastructure cell parts must be performed in bacteria by the cell membrane and its infoldings called mesosomes. http://www.trueorigin.org/atp.asp The Darwinian Basis of the Prokaryote-to-Eukaryote Transition Collapses - Nov. 2010 http://www.evolutionnews.org/2010/11/on_the_energetics_of_genome_co040431.html Evolution vs ATP Synthase - Molecular Machine - video http://www.metacafe.com/watch/4012706 The ATP Synthase Enzyme - exquisite motor necessary for first life - video http://www.youtube.com/watch?v=W3KxU63gcF4 The inner life of a cell - Harvard University - video http://www.youtube.com/watch?v=mbcWGU8fpxA User's guide to the video http://sparkleberrysprings.com/innerlifeofcell.html The Cell - A World Of Complexity Darwin Never Dreamed Of - Donald E. Johnson - video http://www.metacafe.com/watch/4139390 Ben Stein - EXPELLED - The Staggering Complexity Of The Cell - video http://www.metacafe.com/watch/4227700 Articles and Videos on Molecular Motors http://docs.google.com/Doc?docid=0AYmaSrBPNEmGZGM4ejY3d3pfMzlkNjYydmRkZw&hl=en Michael Behe - Life Reeks Of Design - 2010 - video http://www.metacafe.com/watch/5066181 Stephen Meyer - Functional Proteins And Information For Body Plans - video http://www.metacafe.com/watch/4050681 Intelligent Design - The Anthropic Hypothesis http://lettherebelight-77.blogspot.com/2009/10/intelligent-design-anthropic-hypothesis_19.html
18 Nov 2010
1911
Share Video

6:47
Animators website: Virtual Cell Animation Collection http://vcell.ndsu.edu/animations/home.htm The Cell as a Collection of Protein Machines "We have always underestimated cells. Undoubtedly we still do today,,, Indeed, the entire cell can be viewed as a factory that contains an elaborate network of interlocking assembly lines, each which is composed of a set of large protein machines." Bruce Alberts: Former President, National Academy of Sciences; http://www.imbb.forth.gr/people/aeconomou/documents/Alberts98.pdf Molecular Machine - Nuclear Pore Complex - Stephen C. Meyer - video http://www.metacafe.com/watch/4261990/ Simulations reveal new information about the gateway to the cell nucleus Excerpt: “There are whole machines in living cells that are made of hundreds or thousands of proteins,” says Schulten, “and the nuclear pore is one of those systems. It’s actually one of the most magnificent systems in the cell.”,,,Hundreds to thousands of NPCs are embedded in the nuclear envelope of each cell,"... http://www.psc.edu/science/2006/schulten/ Nuclear pore: Excerpt: Nuclear pores allow the transport of water-soluble molecules across the nuclear envelope. This transport includes RNA and ribosomes moving from nucleus to the cytoplasm and proteins (such as DNA polymerase and lamins), carbohydrates, signal molecules and lipids moving into the nucleus. It is notable that the nuclear pore complex (NPC) can actively conduct 1000 translocations per complex per second. http://en.wikipedia.org/wiki/Nuclear_pore#Transport_through_the_nuclear_pore_complex The DNA Code - Solid Scientific Proof Of Intelligent Design - Perry Marshall - video http://www.metacafe.com/watch/4060532 "A code system is always the result of a mental process (it requires an intelligent origin or inventor). It should be emphasized that matter as such is unable to generate any code. All experiences indicate that a thinking being voluntarily exercising his own free will, cognition, and creativity, is required. ,,,there is no known law of nature and no known sequence of events which can cause information to originate by itself in matter. Werner Gitt 1997 In The Beginning Was Information pp. 64-67, 79, 107." (The retired Dr Gitt was a director and professor at the German Federal Institute of Physics and Technology (Physikalisch-Technische Bundesanstalt, Braunschweig), the Head of the Department of Information Technology.) The coding system used for living beings is optimal from an engineering standpoint. Werner Gitt - In The Beginning Was Information - p. 95 Collective evolution and the genetic code - 2006: Excerpt: The genetic code could well be optimized to a greater extent than anything else in biology and yet is generally regarded as the biological element least capable of evolving. http://www.pnas.org/content/103/28/10696.full Here, we show that the universal genetic code can efficiently carry arbitrary parallel codes much better than the vast majority of other possible genetic codes.... the present findings support the view that protein-coding regions can carry abundant parallel codes. http://genome.cshlp.org/content/17/4/405.full The data compression of some stretches of human DNA is estimated to be up to 12 codes thick (12 different ways of DNA transcription) (Trifonov, 1989). (This is well beyond the complexity of any computer code ever written by man). John Sanford - Genetic Entropy Do you believe Richard Dawkins exists? Excerpt: DNA is the best information storage mechanism known to man. A single pinhead of DNA contains as much information as could be stored on 2 million two-terabyte hard drives. http://creation.com/does-dawkins-exist Journey Inside The Cell (DNA to RNA to Protein)- Stephen Meyer - video http://www.youtube.com/watch?v=1fiJupfbSpg BioVisions - The Inner Life of the Cell - video http://vimeo.com/14691840 User's guide to the video http://sparkleberrysprings.com/innerlifeofcell.html Honors to Researchers Who Probed Atomic Structure of Ribosomes - Robert F. Service Excerpt: "The ribosome’s dance, however, is more like a grand ballet, with dozens of ribosomal proteins and subunits pirouetting with every step while other key biomolecules leap in, carrying other dancers needed to complete the act.” http://www.creationsafaris.com/crev200910.htm#20091015a The Ribosome: Perfectionist Protein-maker Trashes Errors Excerpt: The enzyme machine that translates a cell's DNA code into the proteins of life is nothing if not an editorial perfectionist...the ribosome exerts far tighter quality control than anyone ever suspected over its precious protein products... To their further surprise, the ribosome lets go of error-laden proteins 10,000 times faster than it would normally release error-free proteins, a rate of destruction that Green says is "shocking" and reveals just how much of a stickler the ribosome is about high-fidelity protein synthesis. http://www.sciencedaily.com/releases/2009/01/090107134529.htm RNA: Protein Regulators Are Themselves Regulated “What was formerly conceived of as a direct, straightforward pathway is gradually turning out to be a dense network of regulatory mechanisms: genes are not simply translated into proteins via mRNA (messenger RNA). MicroRNAs control the translation of mRNAs (messenger RNAs) into proteins, and proteins in turn regulate the microRNAs at various levels.” http://www.sciencedaily.com/releases/2009/09/090910084147.htm The Case Against a Darwinian Origin of Protein Folds - Douglas Axe - 2010 Excerpt Pg. 11: "Based on analysis of the genomes of 447 bacterial species, the projected number of different domain structures per species averages 991. Comparing this to the number of pathways by which metabolic processes are carried out, which is around 263 for E. coli, provides a rough figure of three or four new domain folds being needed, on average, for every new metabolic pathway. In order to accomplish this successfully, an evolutionary search would need to be capable of locating sequences that amount to anything from one in 10^159 to one in 10^308 possibilities, something the neo-Darwinian model falls short of by a very wide margin." http://bio-complexity.org/ojs/index.php/main/article/view/BIO-C.2010.1 The Case Against a Darwinian Origin of Protein Folds - Douglas Axe, Jay Richards - audio http://intelligentdesign.podomatic.com/player/web/2010-05-03T11_09_03-07_00 A Few Hundred Thousand Computers vs. A Single Protein Molecule - video http://www.metacafe.com/watch/4018233 "The likelihood of developing two binding sites in a protein complex would be the square of the probability of developing one: a double CCC (chloroquine complexity cluster), 10^20 times 10^20, which is 10^40. There have likely been fewer than 10^40 cells in the entire world in the past 4 billion years, so the odds are against a single event of this variety (just 2 binding sites being generated by accident) in the history of life. It is biologically unreasonable." Michael J. Behe PhD. (from page 146 of his book "Edge of Evolution") Nature Paper,, Finds Darwinian Processes Lacking - Michael Behe - Oct. 2009 Excerpt: Now, thanks to the work of Bridgham et al (2009), even such apparently minor switches in structure and function (of a protein to its supposed ancestral form) are shown to be quite problematic. It seems Darwinian processes can’t manage to do even as much as I had thought. (which was 1 in 10^40 for just 2 binding sites) http://www.evolutionnews.org/2009/10/nature_paper_finally_reaches_t.html Mitochondria - Molecular Machine - Powerhouse Of The Cell - video http://www.metacafe.com/watch/5510941/ Evolution Vs ATP Synthase - Molecular Machine - video http://www.metacafe.com/watch/4012706/ The Cell - A World Of Complexity Darwin Never Dreamed Of - Donald E. Johnson - video http://www.metacafe.com/watch/4139390 Systems biology: Untangling the protein web - July 2009 Excerpt: Vidal thinks that technological improvements — especially in nanotechnology, to generate more data, and microscopy, to explore interaction inside cells, along with increased computer power — are required to push systems biology forward. "Combine all this and you can start to think that maybe some of the information flow can be captured," he says. But when it comes to figuring out the best way to explore information flow in cells, Tyers jokes that it is like comparing different degrees of infinity. "The interesting point coming out of all these studies is how complex these systems are — the different feedback loops and how they cross-regulate each other and adapt to perturbations are only just becoming apparent," he says. "The simple pathway models are a gross oversimplification of what is actually happening." http://www.nature.com/nature/journal/v460/n7253/full/460415a.html 10 Ways Darwin Got It Wrong Excerpt: As molecular biologist Jonathan Wells and mathematician William Dembski point out: “It’s true that eukaryotic cells are the most complicated cells we know. But the simplest life forms we know, the prokaryotic cells (such as bacteria, which lack a nucleus), are themselves immensely complex.,,, There is no evidence whatsoever of earlier, more primitive life forms from which prokaryotes might have evolved” (How to Be an Intellectually Fulfilled Atheist (or Not), 2008, p. 4). These authors then mention what these two types of cells share in terms of complexity: • Information processing, storage and retrieval. • Artificial languages and their decoding systems. • Error detection, correction and proofreading devices for quality control. • Digital data-embedding technology. • Transportation and distribution systems. • Automated parcel addressing (similar to zip codes and UPS labels). • Assembly processes employing pre-fabrication and modular construction. • Self-reproducing robotic manufacturing plants. So it turns out that cells are far more complex and sophisticated than Darwin could have conceived of. How did mere chance produce this, when even human planning and engineering cannot? http://www.gnmagazine.org/issues/gn85/10-ways-darwin-wrong.htm Quantum Mechanics at Work in Photosynthesis: Algae Familiar With These Processes for Nearly Two Billion Years - Feb. 2010 Excerpt: "We were astonished to find clear evidence of long-lived quantum mechanical states involved in moving the energy. Our result suggests that the energy of absorbed light resides in two places at once -- a quantum superposition state, or coherence -- and such a state lies at the heart of quantum mechanical theory.",,, "It suggests that algae knew about quantum mechanics nearly two billion years before humans," says Scholes. http://www.sciencedaily.com/releases/2010/02/100203131356.htm Quantum Information/Entanglement In DNA & Protein Folding - short video http://www.metacafe.com/watch/5936605/ Further evidence that quantum entanglement/information is found throughout entire protein structures: http://www.uncommondescent.com/intelligent-design/rescue-proteins-leave-evolutionists-in-the-ditch/#comment-373214 It is very interesting to note that quantum entanglement, which conclusively demonstrates that ‘information’ is completely transcendent of any time and space constraints (Alain Aspect), should be found in molecular biology, for how can quantum entanglement, in molecular biology, possibly be explained by the materialistic framework of neo-Darwinism, a framework which is predicated on the presupposition of being constrained by time and space, when Alain Aspect and company falsified the validity of local realism (reductive materialism) in the first place with quantum entanglement? It is simply ludicrous to appeal to the materialistic framework, which undergirds the entire neo-Darwinian framework, that has been falsified by the very same quantum entanglement effect that one is seeking an explanation to! To give a coherent explanation for an effect that is shown to be completely independent of any time and space constraints one is forced to appeal to a cause that is itself not limited to time and space! Probability arguments, which have been a staple of the arguments against neo-Darwinism, simply do not apply! Further notes: The ‘Fourth Dimension’ Of Living Systems https://docs.google.com/document/pub?id=1Gs_qvlM8-7bFwl9rZUB9vS6SZgLH17eOZdT4UbPoy0Y Astonishingly, actual motors, which far surpass man-made motors in 'engineering parameters', are now being found inside 'simple cells'. Articles and Videos on Molecular Motors/Machines http://docs.google.com/Doc?docid=0AYmaSrBPNEmGZGM4ejY3d3pfMzlkNjYydmRkZw&hl=en Michael Behe - Life Reeks Of Design - 2010 - video http://www.metacafe.com/watch/5066181 And in spite of the fact of finding molecular motors permeating the simplest of bacterial life, there are no detailed Darwinian accounts for the evolution of even one such motor or system. "There are no detailed Darwinian accounts for the evolution of any fundamental biochemical or cellular system only a variety of wishful speculations. It is remarkable that Darwinism is accepted as a satisfactory explanation of such a vast subject." James Shapiro - Molecular Biologist Intelligent Design - The Anthropic Hypothesis http://lettherebelight-77.blogspot.com/2009/10/intelligent-design-anthropic-hypothesis_19.html
11 Mar 2011
1270
Share Video

6:05
The Cell - A World Of Complexity Darwin Never Dreamed Of - Donald E. Johnson - video http://www.metacafe.com/watch/4139390 Articles and Videos on Molecular Motors http://docs.google.com/Doc?docid=0AYmaSrBPNEmGZGM4ejY3d3pfMzlkNjYydmRkZw&hl=en Cells Are Like Robust Computational Systems, - June 2009 Excerpt: Gene regulatory networks in cell nuclei are similar to cloud computing networks, such as Google or Yahoo!, researchers report today in the online journal Molecular Systems Biology. The similarity is that each system keeps working despite the failure of individual components, whether they are master genes or computer processors. ,,,,"We now have reason to think of cells as robust computational devices, employing redundancy in the same way that enables large computing systems, such as Amazon, to keep operating despite the fact that servers routinely fail." http://www.sciencedaily.com/releases/2009/06/090616103205.htm Systems biology: Untangling the protein web - July 2009 Excerpt: Vidal thinks that technological improvements — especially in nanotechnology, to generate more data, and microscopy, to explore interaction inside cells, along with increased computer power — are required to push systems biology forward. "Combine all this and you can start to think that maybe some of the information flow can be captured," he says. But when it comes to figuring out the best way to explore information flow in cells, Tyers jokes that it is like comparing different degrees of infinity. "The interesting point coming out of all these studies is how complex these systems are — the different feedback loops and how they cross-regulate each other and adapt to perturbations are only just becoming apparent," he says. "The simple pathway models are a gross oversimplification of what is actually happening." http://www.nature.com/nature/journal/v460/n7253/full/460415a.html Three Subsets of Sequence Complexity and Their Relevance to Biopolymeric Information - David L. Abel and Jack T. Trevors - Theoretical Biology & Medical Modelling, Vol. 2, 11 August 2005, page 8 "No man-made program comes close to the technical brilliance of even Mycoplasmal genetic algorithms. Mycoplasmas are the simplest known organism with the smallest known genome, to date. How was its genome and other living organisms' genomes programmed?" http://www.biomedcentral.com/content/pdf/1742-4682-2-29.pdf Simulations reveal new information about the gateway to the cell nucleus Excerpt: “There are whole machines in living cells that are made of hundreds or thousands of proteins,” says Schulten, “and the nuclear pore is one of those systems. It’s actually one of the most magnificent systems in the cell.”,,,Hundreds to thousands of NPCs are embedded in the nuclear envelope of each cell,"... http://www.psc.edu/science/2006/schulten/ Life Leads the Way to Invention - Feb. 2010 Excerpt: a cell is 10,000 times more energy-efficient than a transistor. “ In one second, a cell performs about 10 million energy-consuming chemical reactions, which altogether require about one picowatt (one millionth millionth of a watt) of power.” This and other amazing facts lead to an obvious conclusion: inventors ought to look to life for ideas.,,, Essentially, cells may be viewed as circuits that use molecules, ions, proteins and DNA instead of electrons and transistors. That analogy suggests that it should be possible to build electronic chips – what Sarpeshkar calls “cellular chemical computers” – that mimic chemical reactions very efficiently and on a very fast timescale. http://creationsafaris.com/crev201002.htm#20100226a “Each cell with genetic information, from bacteria to man, consists of artificial languages and their decoding systems, memory banks for information storage and retrieval, elegant control systems regulating the automated assembly of parts and components, error fail-safe and proof-reading devices utilized for quality control, assembly processes involving the principle of prefabrication and modular construction and a capacity not equaled in any of our most advanced machines, for it would be capable of replicating its entire structure within a matter of a few hours" Geneticist Michael Denton PhD. Evolution: A Theory In Crisis pg. 329 "To grasp the reality of life as it has been revealed by molecular biology, we must first magnify a cell a thousand million times until it is 20 kilometers in diameter and resembles a giant airship large enough to cover a great city like London or New York. What we would see then would be an object of unparalleled complexity,...we would find ourselves in a world of supreme technology and bewildering complexity." Geneticist Michael Denton PhD., Evolution: A Theory In Crisis, pg.328 Michael Behe - Life Reeks Of Design - 2010 - video http://www.metacafe.com/watch/5066181 And in spite of the fact of finding molecular motors permeating the simplest of bacterial life, there are no detailed Darwinian accounts for the evolution of even one such motor or system. "There are no detailed Darwinian accounts for the evolution of any fundamental biochemical or cellular system only a variety of wishful speculations. It is remarkable that Darwinism is accepted as a satisfactory explanation of such a vast subject. James Shapiro - Molecular Biologist The following expert doesn't even hide his very unscientific preconceived philosophical bias against intelligent design,,, ‘We should reject, as a matter of principle, the substitution of intelligent design for the dialogue of chance and necessity,,, Yet at the same time the same expert readily admits that neo-Darwinism has ZERO evidence for the chance and necessity of material processes producing any cellular system whatsoever,,, ,,,we must concede that there are presently no detailed Darwinian accounts of the evolution of any biochemical or cellular system, only a variety of wishful speculations.’ Franklin M. Harold,* 2001. The way of the cell: molecules, organisms and the order of life, Oxford University Press, New York, p. 205. *Professor Emeritus of Biochemistry, Colorado State University, USA Michael Behe - No Scientific Literature For Evolution of Any Irreducibly Complex Molecular Machines http://www.metacafe.com/watch/5302950/ “The response I have received from repeating Behe's claim about the evolutionary literature, which simply brings out the point being made implicitly by many others, such as Chris Dutton and so on, is that I obviously have not read the right books. There are, I am sure, evolutionists who have described how the transitions in question could have occurred.” And he continues, “When I ask in which books I can find these discussions, however, I either get no answer or else some titles that, upon examination, do not, in fact, contain the promised accounts. That such accounts exist seems to be something that is widely known, but I have yet to encounter anyone who knows where they exist.” David Ray Griffin - retired professor of philosophy of religion and theology Doug Axe Knows His Work Better Than Steve Matheson Excerpt: Regardless of how the trials are performed, the answer ends up being at least half of the total number of password possibilities, which is the staggering figure of 10^77 (written out as 100, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000). Armed with this calculation, you should be very confident in your skepticism, because a 1 in 10^77 chance of success is, for all practical purposes, no chance of success. My experimentally based estimate of the rarity of functional proteins produced that same figure, making these likewise apparently beyond the reach of chance. http://www.evolutionnews.org/2010/06/doug_axe_knows_his_work_better035561.html Evolution vs. Functional Proteins - Doug Axe - Video http://www.metacafe.com/watch/4018222 Intelligent Design - The Anthropic Hypothesis http://lettherebelight-77.blogspot.com/2009/10/intelligent-design-anthropic-hypothesis_19.html
31 Jul 2011
945
Share Video

8:42
Best Look Ever at Lifes Smallest Rotary Motor - article Excerpt: They imaged 19,825 motors to increase the average resolution down to 1.6 Angstroms (16 nanometers, or billionths of a meter). As a result, they were able to map out all the parts in better detail than ever, which are shown in photographs and diagrams in the paper. http://www.creationsafaris.com/crev201001.htm#20100107c "There are no detailed Darwinian accounts for the evolution of any fundamental biochemical or cellular system only a variety of wishful speculations. It is remarkable that Darwinism is accepted as a satisfactory explanation of such a vast subject." James Shapiro - Molecular Biologist ATP Synthase achieves nearly 100% efficiency which far surpasses any human engineered motor: A rotary molecular motor that can work at near 100% efficiency: Excerpt: In cells, the free energy of ATP hydrolysis is ca. 90 pN nm per ATP molecule, suggesting that the F1 motor can work at near 100% efficiency. We confirmed in vitro that F1 indeed does ca. 80 pN nm of work under the condition where the free energy per ATP is 90 pN nm. The high efficiency may be related to the fully reversible nature of the F1 motor: http://rstb.royalsocietypublishing.org/content/355/1396/473.abstract Worlds Smallest Rotary Engine Highlighted Excerpt: The match implies 100% efficiency for the conversion of the Gibbs free energy of ATP hydrolysis into mechanical work performed on the elastically strained filament. This is not surprising given the approximate thermodynamic equilibrium of the enzyme (long)-filament construct. http://www.creationsafaris.com/crev200905.htm#20090525a ATP: The Perfect Energy Currency for the Cell Jerry Bergman, Ph.D. http://www.trueorigin.org/atp.asp Excerpt: Without ATP, life as we understand it could not exist. It is a perfectly-designed, intricate molecule that serves a critical role in providing the proper size energy packet for scores of thousands of classes of reactions that occur in all forms of life. Even viruses rely on an ATP molecule identical to that used in humans. The ATP energy system is quick, highly efficient, produces a rapid turnover of ATP, and can rapidly respond to energy demand changes (Goodsell, 1996, p.79). Furthermore, the ATP molecule is so enormously intricate that we are just now beginning to understand how it works. Each ATP molecule is over 500 atomic mass units (500 AMUs). In manufacturing terms, the ATP molecule is a machine with a level of organization on the order of a research microscope or a standard television (Darnell, Lodish, and Baltimore, 1996). Among the questions evolutionists must answer include the following, 'How did life exist before ATP?' 'How could life survive without ATP since no form of life we know of today can do that?' and 'How could ATP evolve and where are the many transitional forms required to evolve the complex ATP molecule?' No feasible candidates exist and none can exist because only a perfect ATP molecule can properly carry out its role in the cell. In addition, a potential ATP candidate molecule would not be selected for by evolution until it was functional and life could not exist without ATP or a similar molecule that would have the same function. ATP is an example of a molecule that displays irreducible complexity which cannot be simplified and still function (Behe, 1996). ATP could have been created only as a unit to function immediately in life and the same is true of the other intricate energy molecules used in life such as GTP. Although other energy molecules can be used for certain cell functions, none can even come close to satisfactorily replacing all the many functions of ATP. Over 100,000 other detailed molecules like ATP have also been designed to enable humans to live, and all the same problems related to their origin exist for them all. Many macromolecules that have greater detail than ATP exist, as do a few that are less highly organized, and in order for life to exist all of them must work together as a unit. Intelligent Design - The Anthropic Hypothesis http://lettherebelight-77.blogspot.com/ Three subsets of sequence complexity and their relevance to biopolymeric information: Excerpt: We repeat that a single incident of nontrivial algorithmic programming success achieved without selection for fitness at the decision-node programming level would falsify any of these null hypotheses. This renders each of these hypotheses scientifically testable. We offer the prediction that none of these four hypotheses will be falsified. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1208958
1 Oct 2010
3735
Share Video

5:31
The first thought I had when I saw the bacteriophage virus is that it looks similar to the lunar lander of the Apollo program. The comparison is not without merit considering some of the relative distances to be traveled and the virus must somehow possess, as of yet unelucidated, orientation, guidance, docking, unloading, loading, etc... mechanisms. And please remember this level of complexity exists in a world that is far too small to be seen with the naked eye. This excellent video gives a small glimpse at the intricate, and humbling, complexity that goes into crafting the "simple" non-living bacteriophage virus. For anyone who has a molecular biology project they would like to bring to life with such stunning animation, please contact: Seyet LLC - Life Science Animation | Visual Communication Company http://www.seyet.com/ "There are no detailed Darwinian accounts for the evolution of any fundamental biochemical or cellular system only a variety of wishful speculations. It is remarkable that Darwinism is accepted as a satisfactory explanation of such a vast subject." James Shapiro - Molecular Biologist CELL TO VIRUS - SIZE AND SCALE - Move Cursor At Bottom Of Graph To Zoom In http://learn.genetics.utah.edu/content/begin/cells/scale/ The Capabilities of Chaos and Complexity: David L. Abel - Null Hypothesis For Information Generation - 2009 To focus the scientific communitys attention on its own tendencies toward overzealous metaphysical imagination bordering on wish-fulfillment, we propose the following readily falsifiable null hypothesis, and invite rigorous experimental attempts to falsify it: "Physicodynamics cannot spontaneously traverse The Cybernetic Cut: physicodynamics alone cannot organize itself into formally functional systems requiring algorithmic optimization, computational halting, and circuit integration." A single exception of non trivial, unaided spontaneous optimization of formal function by truly natural process would falsify this null hypothesis. http://www.mdpi.com/1422-0067/10/1/247/pdf http://mdpi.com/1422-0067/10/1/247/ag Intelligent Design - The Anthropic Hypothesis http://lettherebelight-77.blogspot.com/
20 Jan 2010
7382
Share Video

7:37
Genetic Entropy Refutation of Nick Matzke's TTSS (type III secretion system) to Flagellum Evolutionary Narrative: excerpt: .....Comparative genomic analysis show that flagellar genes have been differentially lost in endosymbiotic bacteria of insects. Only proteins involved in protein export within the flagella assembly pathway (type III secretion system and the basal-body) have been kept... http://mbe.oxfordjournals.org/cgi/content/abstract/msn153v1 "One fact in favour of the flagellum-first view is that bacteria would have needed propulsion before they needed T3SSs, which are used to attack cells that evolved later than bacteria. Also, flagella are found in a more diverse range of bacterial species than T3SSs. The most parsimonious explanation is that the T3SS arose later," Howard Ochman - Biochemist - New Scientist (Feb 16, 2008) Michael Behe on Falsifying Intelligent Design - video http://www.youtube.com/watch?v=N8jXXJN4o_A Bacterial Flagella - A Paradigm for Design - Scott Minnich - video http://www.youtube.com/watch?v=N949Ysm0KTY http://www.veritas.org/media/talks/92 http://www.nanonet.go.jp/english/mailmag/2004/011a.html http://video.google.it/videoplay?docid=-2771020846872851325 Functional Diagram e-coli http://www.veritas-ucsb.org/library/origins/IMAGES/1.gif Genetic analysis of coordinate flagellar and type III - Minnich and Meyer Molecular machines display a key signature or hallmark of design, namely, irreducible complexity. In all irreducibly complex systems in which the cause of the system is known by experience or observation, intelligent design or engineering played a role the origin of the system. http://www.discovery.org/scripts/viewDB/filesDB-download.php?id=389 Flagellum - Sean D. Pitman, M.D. http://www.detectingdesign.com/flagellum.html The Capabilities of Chaos and Complexity: David L. Abel - Null Hypothesis For Information Generation - 2009 To focus the scientific communitys attention on its own tendencies toward overzealous metaphysical imagination bordering on wish-fulfillment, we propose the following readily falsifiable null hypothesis, and invite rigorous experimental attempts to falsify it: Physicodynamics cannot spontaneously traverse The Cybernetic Cut: physicodynamics alone cannot organize itself into formally functional systems requiring algorithmic optimization, computational halting, and circuit integration. http://www.mdpi.com/1422-0067/10/1/247/pdf http://mdpi.com/1422-0067/10/1/247/ag Proteins Are Extremely Rare - Doug Axe - Video http://www.youtube.com/watch?v=h38Xi-Jz9yk Virus - Assembly Of A Nano-Machine - video http://www.youtube.com/watch?v=Ofd_lgEymto "There are no detailed Darwinian accounts for the evolution of any fundamental biochemical or cellular system only a variety of wishful speculations. It is remarkable that Darwinism is accepted as a satisfactory explanation of such a vast subject." James Shapiro - Molecular Biologist Intelligent Design - The Anthropic Hypothesis http://lettherebelight-77.blogspot.com/
27 Jun 2011
7846
Share Video

4:57
Design without a Designer? — December 9th, 2009 by Douglas Axe Excerpt: For one protein subjected to this kind of experiment, the conclusion was that working sequences are as rare as one in a trillion trillion trillion trillion trillion trillion. In other words, they are unimaginably rare— far too rare to be stumbled upon by any unguided search, such as a Darwinian search. Notice that this isn't a negative result in the sense of an unsuccessful attempt to measure something. The measurement was successful. Some will still see it as a negative result in that it precludes unguided searches. But since we do in fact encounter meaningful sentences every day, we know that intelligence is fully capable of producing what chance simply cannot produce. So we ought also to see this as a positive result— one that confirms the design explanation just as decisively as it refutes the Darwinian one. http://biologicinstitute.org/2009/12/09/design-without-a-designer/ Eighty percent of proteins are different between humans and chimpanzees; Gene; Volume 346, 14 February 2005: http://www.ncbi.nlm.nih.gov/pubmed/15716009 John 1:1-3 In the beginning, the Word existed. The Word was with God, and the Word was God. He was with God in the beginning Through him all things were made; without him nothing was made that has been made. (of note: "Word" in Greek is "Logos", and is the root word from which we get our word "Logic") Darwin's Dilemma Trailer - Excellent Cambrian Explosion Movie Now Available On DVD - Sept. 2009 http://www.illustramedia.com/ddinfo.htm Estimating the prevalence of protein sequences adopting functional enzyme folds: Doug Axe: Excerpt: this implies the overall prevalence of sequences performing a specific function by any domain-sized fold may be as low as 1 in 10^77, adding to the body of evidence that functional folds require highly extraordinary sequences. (of note: the universe only has 10^80 sub-atomic particles) http://www.ncbi.nlm.nih.gov/pubmed/15321723 A Man-Made ATP-Binding Protein Evolved Independent of Nature Causes Abnormal Growth in Bacterial Cells Excerpt: "Recent advances in de novo protein evolution have made it possible to create synthetic proteins from unbiased libraries that fold into stable tertiary structures with predefined functions. However, it is not known whether such proteins will be functional when expressed inside living cells or how a host organism would respond to an encounter with a non-biological protein. Here, we examine the physiology and morphology of Escherichia coli cells engineered to express a synthetic ATP-binding protein evolved entirely from non-biological origins. We show that this man-made protein disrupts the normal energetic balance of the cell by altering the levels of intracellular ATP. This disruption cascades into a series of events that ultimately limit reproductive competency by inhibiting cell division." http://www.plosone.org/article/info:doi%2F10.1371%2Fjournal.pone.0007385 Evolution vs ATP Synthase - Molecular Machine - video http://www.youtube.com/watch?v=qE3QJMI-ljc Mutations are rare phenomena, and a simultaneous change of even two amino acid residues in one protein is totally unlikely. One could think, for instance, that by constantly changing amino acids one by one, it will eventually be possible to change the entire sequence substantially These minor changes, however, are bound to eventually result in a situation in which the enzyme has ceased to perform its previous function but has not yet begun its new duties. It is at this point it will be destroyed - along with the organism carrying it. Maxim D. Frank-Kamenetski, Unraveling DNA, 1997, p. 72. (Professor at Brown U. Center for Advanced Biotechnology and Biomedical Engineering) The Ribosome, which makes the proteins, is found to be severely intolerant to any "random mutations". The Ribosome: Perfectionist Protein-maker Trashes Errors Excerpt: The enzyme machine that translates a cell's DNA code into the proteins of life is nothing if not an editorial perfectionist...the ribosome exerts far tighter quality control than anyone ever suspected over its precious protein products... To their further surprise, the ribosome lets go of error-laden proteins 10,000 times faster than it would normally release error-free proteins, a rate of destruction that Green says is "shocking" and reveals just how much of a stickler the ribosome is about high-fidelity protein synthesis. http://www.sciencedaily.com/releases/2009/01/090107134529.htm Intelligent Design - The Anthropic Hypothesis http://lettherebelight-77.blogspot.com/
9 Feb 2010
12835
Share Video

8:05
SIGNATURE IN THE CELL by Stephen C. Meyer http://www.signatureinthecell.com/ Journey Inside The Cell - video http://www.youtube.com/watch?v=1fiJupfbSpg Evolution vs. Functional Proteins - Doug Axe - Video http://www.youtube.com/watch?v=M4FvdOxIDfU Estimating the prevalence of protein sequences adopting functional enzyme folds: Doug Axe: Excerpt: Combined with the estimated prevalence of plausible hydropathic patterns (for any fold) and of relevant folds for particular functions, this implies the overall prevalence of sequences performing a specific function by any domain-sized fold may be as low as 1 in 10^77, adding to the body of evidence that functional folds require highly extraordinary sequences. http://www.ncbi.nlm.nih.gov/pubmed/15321723 Refutation of Szostak's 1 in 10^12 functional protein paper: A Man-Made ATP-Binding Protein Evolved Independent of Nature Causes Abnormal Growth in Bacterial Cells Excerpt: "Recent advances in de novo protein evolution have made it possible to create synthetic proteins from unbiased libraries that fold into stable tertiary structures with predefined functions. However, it is not known whether such proteins will be functional when expressed inside living cells or how a host organism would respond to an encounter with a non-biological protein. Here, we examine the physiology and morphology of Escherichia coli cells engineered to express a synthetic ATP-binding protein evolved entirely from non-biological origins. We show that this man-made protein disrupts the normal energetic balance of the cell by altering the levels of intracellular ATP. This disruption cascades into a series of events that ultimately limit reproductive competency by inhibiting cell division." http://www.plosone.org/article/info:doi%2F10.1371%2Fjournal.pone.0007385 Eighty percent of proteins are different between humans and chimpanzees; Gene; Volume 346, 14 February 2005: http://www.ncbi.nlm.nih.gov/pubmed/15716009 Yet by the late 1980s it was becoming obvious to most genetic researchers, including myself, since my own main research interest in the 80s and 90s was human genetics, that the heroic effort to find the information specifying lifes order in the genes had failed. There was no longer the slightest justification for believing that there exists anything in the genome remotely resembling a program capable of specifying in detail all the complex order of the phenotype (Body Plan)." Michael John Denton page 172 of Uncommon Dissent Waiting Longer for Two Mutations, Part 5 - Michael Behe Excerpt: the appearance of a particular (beneficial) double mutation in humans would have an expected time of appearance of 216 million years, http://behe.uncommondescent.com/2009/03/waiting-longer-for-two-mutations-part-5/ Cortical Inheritance: The Crushing Critique Against Genetic Reductionism - Arthur Jones - video Part 1 http://www.youtube.com/watch?v=5JzQ8ingdNY Part 2 http://www.youtube.com/watch?v=o1bAX93zQ5o Darwin's Theory - Fruit Flies and Morphology - video http://www.youtube.com/watch?v=hZJTIwRY0bs Evolution vs ATP Synthase - Molecular Machine - video http://www.youtube.com/watch?v=qE3QJMI-ljc The Coding Found In DNA Surpasses Mans Ability to Code - Stephen Meyer - video http://www.youtube.com/watch?v=HavmzWVt8IU Mathematically Defining Functional Information In Molecular Biology - Kirk Durston - video http://www.youtube.com/watch?v=vUeCgTN7pOo The malaria parasite, and AIDS virus, due to their comparatively enormous population size, have in 1 year more mutation/duplication/selection events than all mammal lineages have had in the entire +100 million years they have been in the fossil record. What do we see? Michael Behe, The Edge of Evolution, pg. 162 Swine Flu, Viruses, and the Edge of Evolution "Indeed, the work on malaria and AIDS demonstrates that after all possible unintelligent processes in the cell--both ones we've discovered so far and ones we haven't--at best extremely limited benefit, since no such process was able to do much of anything. It's critical to notice that no artificial limitations were placed on the kinds of mutations or processes the microorganisms could undergo in nature. Nothing--neither point mutation, deletion, insertion, gene duplication, transposition, genome duplication, self-organization nor any other process yet undiscovered--was of much use." http://www.evolutionnews.org/2009/05/swine_flu_viruses_and_the_edge.html Intelligent Design - The Anthropic Hypothesis http://lettherebelight-77.blogspot.com/
2 Jun 2010
14132
Share Video

1:36
The best known example for irreducible complexity, and thus for Intelligent Design, in molecular biology has become the bacterial flagellum. Bacterial Flagellum - A Sheer Wonder Of Intelligent Design - video http://www.metacafe.com/watch/3994630/bacterial_flagellum_a_sheer_wonder_of_intelligent_design/ Biologist Howard Berg at Harvard calls the Bacterial Flagellum “the most efficient machine in the universe." The flagellum has steadfastly resisted all attempts to elucidate its plausible origination by Darwinian processes, much less has anyone ever actually evolved a flagellum from scratch in the laboratory; Genetic Entropy Refutation of Nick Matzke's TTSS (type III secretion system) to Flagellum Evolutionary Narrative: Excerpt: Comparative genomic analysis show that flagellar genes have been differentially lost in endosymbiotic bacteria of insects. Only proteins involved in protein export within the flagella assembly pathway (type III secretion system and the basal-body) have been kept... http://mbe.oxfordjournals.org/cgi/content/abstract/msn153v1 Genetic analysis of coordinate flagellar and type III - Scott Minnich and Stephen Meyer Molecular machines display a key signature or hallmark of design, namely, irreducible complexity. In all irreducibly complex systems in which the cause of the system is known by experience or observation, intelligent design or engineering played a role the origin of the system. http://www.discovery.org/scripts/viewDB/filesDB-download.php?id=389 "One fact in favour of the flagellum-first view is that bacteria would have needed propulsion before they needed T3SSs, which are used to attack cells that evolved later than bacteria. Also, flagella are found in a more diverse range of bacterial species than T3SSs. ‘The most parsimonious explanation is that the T3SS arose later," Howard Ochman - Biochemist - New Scientist (Feb 16, 2008) Flagellum - Sean D. Pitman, M.D. http://www.detectingdesign.com/flagellum.html For a broad outline of the "Fitness test", required to be passed to show a violation of the principle of Genetic Entropy, please see the following video and articles: Is Antibiotic Resistance evidence for evolution? - "The Fitness Test" - video http://www.metacafe.com/watch/3995248/is_antibiotic_resistance_evidence_for_evolution_the_fitness_test/ Testing the Biological Fitness of Antibiotic Resistant Bacteria - 2008 http://www.answersingenesis.org/articles/aid/v2/n1/darwin-at-drugstore List Of Degraded Molecular Abilities Of Antibiotic Resistant Bacteria: http://www.trueorigin.org/bacteria01.asp This "fitness test" fairly conclusively demonstrates "optimal information" was originally encoded within a "parent" bacteria/bacterium by God, and has not been added to by any "teleological" methods in the beneficial adaptations of the sub-species of bacteria. Intelligent Design - The Anthropic Hypothesis http://lettherebelight-77.blogspot.com/
9 Sep 2011
1212
Share Video

9:59
Donald E. Johnson Bibliography http://www.amazon.com/Donald-E.-Johnson/e/B001K8LWHQ Dr. Johnson's website: Science Integrity - Exposing Unsubstantiated Science Claims http://scienceintegrity.net/PNNP.aspx http://scienceintegrity.net/default.aspx DNA: The Tiny Code That's Toppling Evolution Excerpt: The DNA molecule carries the genetic language, but the language itself is independent of its carrier. The same genetic information can be written in a book, stored in a compact disk or sent over the Internet, and yet the quality or content of the message has not changed by changing the means of conveying it. http://www.gnmagazine.org/issues/gn58/tinycode.htm ‘DNA computer’ cracks code - 2002 Excerpt: A ‘DNA computer’ has been used for the first time to find the only correct answer from over a million possible solutions to a computational problem. http://physicsworld.com/cws/article/news/5229 Donald Johnson video lecture: http://www.ideaclubtcw.org/video/DEJohnson.html Mathematically Defining Functional Information In Molecular Biology - Kirk Durston - short video http://www.metacafe.com/watch/3995236/mathematically_defining_functional_information_in_molecular_biology_kirk_durston/ Entire video: http://vimeo.com/1775160 The Capabilities of Chaos and Complexity: David L. Abel - Null Hypothesis For Information Generation - 2009 To focus the scientific community’s attention on its own tendencies toward overzealous metaphysical imagination bordering on “wish-fulfillment,” we propose the following readily falsifiable null hypothesis, and invite rigorous experimental attempts to falsify it: "Physicodynamics cannot spontaneously traverse The Cybernetic Cut: physicodynamics alone cannot organize itself into formally functional systems requiring algorithmic optimization, computational halting, and circuit integration." A single exception of non trivial, unaided spontaneous optimization of formal function by truly natural process would falsify this null hypothesis. http://www.mdpi.com/1422-0067/10/1/247/pdf http://mdpi.com/1422-0067/10/1/247/ag The digital code of DNA - 2003 - Leroy Hood & David Galas The discovery of the structure of DNA transformed biology profoundly, catalysing the sequencing of the human genome and engendering a new view of biology as an information science. Two features of DNA structure account for much of its remarkable impact on science: its digital nature and its complementarity, whereby one strand of the helix binds perfectly with its partner. DNA has two types of digital information — the genes that encode proteins, which are the molecular machines of life, and the gene regulatory networks that specify the behaviour of the genes. http://www.nature.com/nature/journal/v421/n6921/full/nature01410.html Stephen Meyer is interviewed about the "information problem" in DNA, Signature in the Cell - video http://downloads.cbn.com/cbnnewsplayer/cbnplayer.swf?aid=8497 The DNA Code - Solid Scientific Proof Of Intelligent Design - Perry Marshall - video http://www.metacafe.com/watch/4060532/the_dna_code_solid_scientific_proof_of_intelligent_design_perry_marshall/ Evolution vs. Functional Proteins - Doug Axe - Video http://www.metacafe.com/watch/4018222/evolution_vs_functional_proteins_where_did_the_information_come_from_doug_axe_stephen_meyer/ "Phosphatase speeds up reactions vital for cell signalling by 10^21 times. Allows essential reactions to take place in a hundreth of a second; without it, it would take a trillion years!" Jonathan Sarfati http://www.pnas.org/content/100/10/5607.abstract Building a Cell: Staggering Complexity: - Feb. 2010 Excerpt: “All organisms, from bacteria to humans, face the daunting task of replicating, packaging and segregating up to two metres (about 6 x 10^9 base pairs) of DNA when each cell divides,” “,,,the segregation machinery must function with far greater accuracy than man-made machines and with an exquisitely soft touch to prevent the DNA strands from breaking.” Bloom and Joglekar talked “machine language” over and over. The cell has specialized machines for all kinds of tasks: segregation machines, packaging machines, elaborate machines, streamlined machines, protein translocation machines, DNA-processing machines, DNA-translocation machines, robust macromolecular machines, accurate machines, ratchets, translocation pumps, mitotic spindles, DNA springs, coupling devices, and more. The authors struggle to “understand how these remarkable machines function with such exquisite accuracy.” http://www.creationsafaris.com/crev201002.htm#20100202a Evolution vs ATP Synthase - Molecular Machine - video http://www.metacafe.com/watch/4012706/evolution_vs_atp_synthase_molecular_machine/ "No man-made program comes close to the technical brilliance of even Mycoplasmal genetic algorithms. Mycoplasmas are the simplest known organism with the smallest known genome, to date. How was its genome and other living organisms' genomes programmed?" - David L. Abel and Jack T. Trevors, “Three Subsets of Sequence Complexity and Their Relevance to Biopolymeric Information,” Theoretical Biology & Medical Modelling, Vol. 2, 11 August 2005, page 8 http://www.biomedcentral.com/content/pdf/1742-4682-2-29.pdf “The problem of the origin of life is clearly basically equivalent to the problem of the origin of biological information.” Origin of life theorist Bernd-Olaf Kuppers in his book "Information and the Origin of Life" Intelligent Design - The Anthropic Hypothesis http://lettherebelight-77.blogspot.com/
14 Mar 2010
6740
Share Video