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Lead is a toxic metal that occurs naturally in the Earth’s crust, but its use in activities such as mining, smelting and the burning of fossil fuels has contaminated the environment, leading to human exposure and public health problems in various parts of the world. Lead is also a key component in paint, pigments, gasoline, ammunition, batteries, stained glass, solder, roofing materials and some cosmetics and medicines.
Lead poisoning refers to when lead accumulates in the body and causes severe health problems. The accumulating lead is distributed to and stored in the brain, kidneys, liver, bones and teeth. Even very small amounts can lead to problems and at very high amounts, it can cause death. Lead exposure is determined by measuring the amount of lead in the blood and no known level of lead exposure is regarded as safe.
Children under 6 years of age are particularly vulnerable to the toxic effects of lead poisoning, which causes profound and permanent problems, particularly ones that affect brain development and the nervous system. Children of this age are particularly vulnerable to lead poisoning because they absorb up to five times more lead when exposed than adults do. Hand-to-mouth behaviors among this age group also increase the risk of objects containing or coated in lead being swallowed. In adults, lead poisoning can also lead to long-term health issues, including hypertension and kidney damage.
During pregnancy, lead is released from bone into the blood, which is a source of exposure to the fetus. Pregnant woman who are exposed to high lead levels are at an increased risk of miscarriage, stillbirth and premature birth.
Lead poisoning occurs when lead is ingested. Breathing in dust that contains lead can also cause it. You cannot smell or taste lead and it’s not visible to the naked eye.
In the United States, lead used to be common in house paint and gasoline. These products are not produced with lead any longer. However, lead is still present every
Some common gallbladder problems include:
Gallstones are solid masses of cholesterol (or pigment) of different sizes. Gallstones occur when high levels of fat and bile cause crystals to form. These crystals may combine over time and expand into stones.
Stones can be as small as a grain of sand or as large as a golf ball. They may or may not cause symptoms.
Common bile duct stones (choledocholithiasis)
Bile is transported from the gallbladder via small tubes and deposited in the common bile duct. From there, it is moved to the small intestine. Sometimes, gallstones can lodge or form in the common bile duct.
Most often, these stones begin their life in the gallbladder and migrate to the common bile duct; this is referred to as a secondary stone or a secondary common bile duct stone.
If the stone forms within the duct itself, it is called a primary stone, or primary common bile duct stone. These are less common but are more likely to cause an infection than secondary stones.
The pain of gallbladder disease almost always has one of two causes - gallstones or cholecystitis. Gallstones are stones that form in the gallbladder (often misspelled "gall bladder"). They vary in size from a millimeter or two to several centimeters and are made up of cholesterol or bile pigments. Cholecystitis means inflammation of the gallbladder. Although, cholecystitis is most commonly caused by gallstones, there are other less common causes as well.
What is the mechanism of gallbladder pain?
Gallstones have a tendency to become lodged in the bile ducts leading from the gallbladder or liver into the intestines. When gallstones lodge in the ducts, they give rise to a specific type of pain called biliary colic. The characteristics of biliary colic are very consistent, and it is important to recognize its characteristics because they direct the physician to the most appropriate test to diagnose gallstones, primarily abdominal ultrasonography. In approximately 5% of cases, ultrasonography will fail to show gallstones. In such situations, if the characteristics of biliary colic are typical, physicians will go on to other more advanced tests for diagnosing gallstones, specifically endoscopic ultrasound. Finally, most gallstones do not cause pain, and are frequently found incidentally during abdominal ultrasonography. If the symptoms for which the ultrasonography is being done are not typical of biliary colic, it is unlikely that the symptoms are caused by gallstones. The gallstones can be truly silent.
This is important to recognize because surgery to remove the gallstones is unlikely to relieve the symptoms.
When gallstones lodge suddenly in the duct leading from the gallbladder (cystic duct), the duct leading from the liver to the cystic duct (common hepatic duct), or the duct leading from the cystic duct to the intestine (common bile duct), the normal flow of bile from the liver is interrupted.
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