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0:27
FDA Approves LIALDA™ (mesalamine), the First Oral Once-Daily Mesalamine For Patients With Active, Mild to Moderate Ulcerative Colitis Basingstoke, UK and Philadelphia, US - January 16, 2007 / PRNewswire / — Shire plc (LSE: SHP, NASDAQ: SHPGY, TSX: SHQ) announced today that the U.S. Food and Drug Administration (FDA) has approved LIALDA™ (mesalamine) with MMX® technology, indicated for the induction of remission in patients with active, mild to moderate ulcerative colitis. LIALDA is the first and only FDA-approved once-daily oral formulation of mesalamine. Mesalamines are a part of a drug class called aminosalicylates, which contain 5-aminosalicyclic acid (5-ASA), a well-established drug of choice and often a first-line treatment for patients with mild to moderate ulcerative colitis. Shire will launch LIALDA in the U.S. in the first quarter of 2007. Once-daily LIALDA with MMX technology contains the highest mesalamine dose per tablet (1.2 g), so patients can take as few as two tablets once daily. Other currently available mesalamines require three to four times daily dosing and 6 to 16 pills a day. A recent study conducted by the Crohn's and Colitis Foundation of America (CCFA) found that 65 percent of patients with ulcerative colitis are poorly compliant with their medication, citing pill burden and inconvenience associated with the medication. "As the first oral once-a-day treatment option for ulcerative colitis, the approval of LIALDA in the United States is great news for patients and physicians when managing this serious condition," said Matthew Emmens, Shire Chief Executive Officer. "Once-daily LIALDA is one of several medicines Shire expects to launch in the U.S. and Europe in 2007." The FDA approval was based on the results of two Phase III clinical studies that found LIALDA (2.4 g/day and 4.8 g/day) was effective in inducing remission in patients with active, mild to moderate ulcerative colitis compared to placebo after eight weeks of treatment. LIALDA is generally well tolerated and has a similar safety profile to other currently available mesalamines. "In clinical trials, LIALDA proved to be an effective medication, providing superior rates of remission compared to placebo for people with ulcerative colitis," said lead study investigator, Gary R. Lichtenstein, M.D., director of the Center for Inflammatory Bowel Diseases at the Hospital of the University of Pennsylvania. "This is the first new mesalamine treatment to enter the market since 2000, filling a major void for physicians and people with ulcerative colitis and simplifying treatment of this disease." "The introduction of new treatments with more convenient dosing regimens may be an important step in helping patients with ulcerative colitis remain compliant with their medication," said Jonathan Braun, M.D., Ph.D., chair of CCFA's National Scientific Advisory Committee. Shire has licensed from Giuliani S.p.A. the exclusive rights to develop and commercialize LIALDA in the U.S., Canada, Europe -- known as MEZAVANT™ -- (excluding Italy) and the Pacific Rim. Giuliani S.p.A. retains the development and commercialization rights in Italy. Cosmo Pharmaceuticals S.p.A., Milan developed the MMX technology and owns the trademark, MMX. For more information on LIALDA, please visit www.LIALDA.com.
18 Jan 2007
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0:16
The Thai Coyote Coup of Fun and Freedom in Bangkok's shopping malls is great entertainment for men and women - it shows a degree of tolerance and good clean fun that is hard to find elsewhere in the world. Here we continue to introduce Sexy SiamGirl and soon Le Falcon will bring you Charismatic China Girl and their solo orgasmic performances - a world's first for erotica lovers! virtual frigging and humping beyond your wildest dreams 5 star China Chick online but hidden bu Metacafe - see it here: http://www.metacafe.com/watch/473467/china_chick_hip_hops_to_fame/
19 Feb 2007
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6:52
AGREEMENT AIMED AT DEVELOPING HIGHER YIELDING CROPS THAT ARE MORE TOLERANT TO ADVERSE ENVIRONMENTAL CONDITIONS BASF and Monsanto Company have announced a long term joint research and development R&D and commercialization collaboration in plant biotechnology that will focus on the development of high yielding crops and crops that are more tolerant to adverse environmental conditions such as drought. The companies will dedicate a joint budget of potentially $1.5 billion to fund a dedicated pipeline of yield and stress tolerance traits for corn, soybeans, cotton and canola. Under this collaboration: Each company will maintain independent trait discovery programs. Each company will nominate specific candidate genes and the most promising candidates will be advanced for accelerated joint development and for commercialization in the Monsanto pipeline. The two companies expect to generate a greater number of viable research projects than they could have done on their own, accelerate the development of new products, and bring a greater number of traits to the market at a faster speed. The nominated projects will be jointly funded at a 50-50 cost sharing through each phase of development as the candidate gene works its way toward commercial status. Products that emerge from the joint development will be commercialized by Monsanto. The companies have agreed to share profits associated with commercialized products, with Monsanto receiving 60 percent of net profits and BASF receiving 40 percent of net profits. For more information, please visit: www.basf.com or www.monsanto.com
25 Mar 2007
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2:02
In this clip from Travel Channel's Culture Shock, Shenaz visits a temple in India where rats are not only tolerated, they are worshipped. Watch as one of the locals dines with the "holy rats" on spoiled milk and feces! Culture Shock premieres April 9 at 8PM E/P.
1 Apr 2007
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1:14
Just 1 minute Epic, with 15 actors! Religion, War and TV, very funny and very fast! Comedy -Brazil 2003 - Subtitle English This movie is about tolerance or the lack of ! We did it as joke, but it is a very rich text, all words and images have a meaning behind the scene. People who can not understand portuguese, should see it and see it again, because it is very fast to you to read and watch at the same time. Finaly, remeber it is only a funny movie, a joke, and try not to get offended please. God is love! God is laughting all the time!
2 May 2007
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0:22
he tolerated all ideologies in the world!
7 May 2007
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2:04
Inside a NASCAR racecar, temperatures can reach up to 140 degrees during a race. While special equipment and training make it tolerable for racecar drivers like Jeff Burton, he wants parents and caregivers to understand that it is extremely dangerous for small children to be left alone in a car, even if it’s only for a short period of time. Safe Kids Worldwide and General Motors have been working together for the last seven years to raise awareness on this issue. Especially, since it is a lot easier for children to get heat exhaustion, than it is for an adult. A child’s core body temperature increases three to five times faster than an adult and unfortunately, in the last nine years, at least 320 small children have died due to heatstroke after being trapped in or intentionally left in automobiles. Experts say nearly 40 percent of child hyperthermia is change-of-schedule related, for example, when dad takes the children to daycare instead of mom who usually does, and forgets the child is in the backseat. The temperature difference between the outside of the car and the inside can be about 45 to 50 degrees or more. And it doesn’t even have to be a hot sunny day. Temperatures can rise very quickly in a car with the windows rolled up. In fact, average tests have shown an increase of 19 to 20 degrees in just ten minutes. For more information, go to: www.safekids.org. Produced for General Motors
9 May 2007
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4:12
Hello , BONJOUR ,ЗДРАВСТВУЛТЕ!, CIAO Jambo, Merhaba !!!!! UNESCO has named 2007 International Year of Rumi the number-one, Hello , BONJOUR ,ЗДРАВСТВУЛТЕ!, CIAO Jambo, Merhaba !!!!! UNESCO has named 2007 International Year of Rumi the number-one, best-selling poet of the United States whose verses read by celebrities like Deepak Chopra,Madonna, Goldie Hawn and Demi Moore . According to Time Magazine Rumi is,Mystic of the Century and according to the New York Times Rumi is the most influential poet in America since the 1960s who has outsold Shakespeare . Who is this Mevlana Mohammed Jelaled-din Rumi , that over 700 years after his death his words and thoughts are causing such a stir and Westerns say that Rumi's philosophy is crucial for peace on the planet today?First , here is one way in which he described himself : Not Christian or Jew or Muslim, not Hindu, Buddhist, sufi, or zen. Not any religion or cultural system. I am not from the East or the West, not out of the ocean or up from the ground, not natural or ethereal, not composed of elements at all. I do not exist, am not an entity in this world or the next, did not descend from Adam and Eve or any origin story. My place is placeless, a trace of the traceless. Neither body or soul. I belong to the beloved, have seen the two worlds as one and that one call to and know, first, last, outer, inner, only that breath breathing human being. Rumi's popularity is all the more remarkable given the suspicions between America and the Muslim world. What is it about Rumi that attracts so many Americans who says : My Mother is Love My Father is Love My Prophet is Love My God is Love I am a child of Love I have come only to speak of Love . America and the Muslim world each insist on viewing the other through its own cultural lens. What Americans cherish as freedom, the Muslim world views as tending towards debauchery. What many Muslims consider pious restraint, Americans see as evidence of control by a misogynist theocracy. Amidst these tensions, Americans from all walks of life are reading Rumi. If the Muslim world and America are so seemingly incomprehensible to each other, how has a medieval dervish from the East nestled so close to America's heart? The answer must be Rumi, was a philosopher and mystic of Islam, but not a Muslim of the orthodox type. His doctrine advocated unlimited tolerance, positive reasoning, goodness, charity and awareness through love. To him and to his disciples all religions were more or less truth. Looking with the same eye on Muslim, Jew and Christian alike, his peaceful and tolerant teaching has appealed to men of all sects and creeds. Come, come again... Whatever you are... Whether you are infidel, idolater or fireworshipper. Whether you have broken your vows of repentance a hundred times This is not the gate of despair, This is the gate of hope. Come, come again... Best regards
13 May 2007
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0:48
Women's Metropolis Parka - Great for cold commutes and enduring the chill of metal 50-yard stadium seats in December, The North Face Metropolis Parka is head-to-knee down warmth ready for any cold snap. If you think that you're allergic to winter, this 600-fill down Metropolis Parka from The North Face could be a temporary cure. It's a long insulated jacket that wraps you from head to knee in amazing warmth. The insulated hood is fully adjustable and can be snapped away for those sunny, frosty days when you simply need a warm headband or your favorite faux fur cap. Internal security pockets help keep your wallet, coin purse and PDA neatly in place without the fear of losing essentials while being jostled on your morning commute. We can't send you south for a vacation, but at least The North Face Metropolis Parka has the thermal performance to make your urban winter tolerable. 50-denier 2.1-oz. plain weave polyester treated with a DWR finish (in light colors) 30-denier 1.69-oz. plain weave nylon with a DWR finish (in dark colors) Comfortable 50-denier plain weave polyester lining Incredibly warm 600-fill down insulation Insulated hood is adjustable and snaps off for easy removal Brushed chinguard lining Zippered internal security pocket Full-length front zipper with snap center front closure along wind flap Zippered handwarmer pockets TNF logo on left front chest Weight: 36.1 oz. (1,022 g.)
14 Jun 2007
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8:48
Phil Johnson, M.D. discusses why it's so important for HIV/AIDS patients to follow their antiretroviral (ARV) medication regimen as prescribed. During active infection, up to 10 billion HIV particles will be created each day. This provides ample chance for the virus to mutate in ways that provide resistance to the medication. By keeping the blood levels of the ARV medication high, that will keep the viral load low and reduce the opportunity for resistance mutations to flourish. When HIV develops resistance to one medication, it may develop resistance to other ones at the same time. Patients may also have to deal with side effects such as the redistribution of fat in the body and increases to their cholesterol level. Not every patient can tolerate every ARV. Therefore, it's critical for patients to make every ARV last as long as possible. When people with resistant HIV have unprotected sex, they may transmit resistant HIV to their sex partners, meaning the newly infected person will have far fewer treatment options. Genetic testing of the virus can be used to determine which medicaions the patient's particular strain(s) will be resistant to.
16 Jun 2007
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6:12
I DONT TOLERATE STUPID PEOPLE!
27 Jun 2007
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3:54
An inspirational song about life and love. I put this slide show together to help express the meaning of the song. It includes pictures of Katrina, 9/11, Virginia Tech, the Iraq war and many others. To find out more about me and learn how I write my music go to: http://jonweems.hostrack.com LYRICS: SPREAD THE LOVE When you see suffering in your fellow man Just reach on out now and extend a helping hand We must all do everything we can To spread the love CHORUS Spread the love Spread the love That love that comes from up above You know this world can't get enough So spread His love I hope some day we can eradicate All the anger, all the prejudice and hate I know it gets so hard to tolerate Just spread the love CHORUS Spread the love Spread the love That love that comes from up above You know this world can't get enough So spread His love Sometimes we feel lost in a sea of uncertainty When things just don't seem to be how they're supposed to be Together we all can guide each other through As God's earthly crew Sailing into the Son lit truth When you see a stranger passing by Flash a friendly smile and look them in the eye If they ever stop to ask you why Say spread the love CHORUS Spread the love Spread the love That love that comes from up above You know this world can't get enough So spread His love
1 Jul 2007
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0:35
This clip is the scar I got from that night! 3 stitches. I waited 14 hrs and it still needed stitches I have a high tolerence for pain! LETS PARTYYYYYY
2 Jul 2007
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2:27
Middle Show Tolerance Correspondents Eric Andre, Chris Clarke and Baron Vaughn show you the alarming sting of racism in America
7 Aug 2007
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1:22
Middle Show Tolerance Correspondents Eric Andre, Chris Clarke and Baron Vaughn show you the alarming sting of racism in America
8 Aug 2007
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2:59
Laurie David is getting divorced from Larry David (the creator of Seinfeld and Curb Your Enthusiasm). Laurie started http://www.stopglobalwarming.org and produced the movie An Inconvenient Truth. I'm an environmentalist. And it seems that Laurie likes neurotic, bald, Jewish fellows. Or can at least tolerate them for many years. So I think we'll work well together. Let's see if she agrees. If anyone knows her, please ask her to watch this.
19 Aug 2007
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