50 Cent and G-Unit are putting on a show somewhere in the middle east. The crowd are pleased, but the promoter refuses to pay 50 and G-Unit. 50 is not going to leave without his money, so he hassles and threatens the promoter. The promoter does not give them money, but a very valuable diamond encrusted skull. 50 and G-Unit are about to leave the country when they are ambushed and the skull is taken away from them. The game then continues with 50 trying to get what's rightfully his and find out who ambushed him and why.