Dan (Robin Williams) and Charlie (John Travolta) are two best friends and co-workers. They apparently have no clue about the importance of family and what life is truly about. Dan's ex-wife Vicki (Kelly Preston) shows up after a long period of time and announces she and Dan have seven-year-old twins: a son and a daughter. Now Dan recruits Charlie and together they have to take care of the twins and a dog. With help from a co-worker (Seth Green), they go from outdoor activities with the kids and a rough instructor (Matt Dillon), to enduring a flamboyant children's entertainer (Bernie Mac) and eventually they will learn the true meaning of life and family.