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Earth's population has been decimated by a virus, related to the mad cow disease, that turns everyone into flesh-craving zombies. Only a handful of humans remain, including Columbus (Jesse Eisenberg), a student at the University of Texas trying to make his way to his home town of Columbus, OH, where he hopes his parents are still alive. Columbus has long been an outsider and somewhat phobic, which he uses to his advantage in avoiding zombies. In fact, zombies are not his greatest fear: clowns are.