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The entire world is hit with an apocalyptic infection that turns people into zombies once they have been bitten by an infected zombie. Columbus (Jesse Eisenberg) is a young geek who has a lot of phobias about almost everything from clowns, to bathrooms, to checking the back seat of cars. Being alone and scared of the outside world has kept him alive. His new fear is being eaten by zombies. To survive, Columbus has begun making a long list of rules to survive. Each time he gives you one of his rules, you see an example of his rule in action. Columbus explains to the audience in a background voice such as wearing your seat-belt, or the double-tap rule after you shoot a zombie make sure he is dead by shooting him in the head again.