"I have seen estimates of the incidence of the ratio of deleterious-to-beneficial mutations which range...
"I have seen estimates of the incidence of the ratio of deleterious-to-beneficial mutations which range from one in one thousand up to one in one million. The best estimates seem to be one in one million (Gerrish and Lenski, 1998). The actual rate of beneficial mutations is so extremely low as to thwart any actual measurement (Bataillon, 2000, Elena et al, 1998). Therefore, I cannot ...accurately represent how rare such beneficial mutations really are." (J.C. Sanford; Genetic Entropy page 24) - 2005
Estimation of spontaneous genome-wide mutation rate parameters: whither beneficial mutations? (Thomas Bataillon)
Abstract......It is argued that, although most if not all mutations detected in mutation accumulation experiments are deleterious, the question of the rate of favourable mutations (and their effects) is still a matter for debate.
Distribution of fitness effects caused by random insertion mutations in Escherichia coli
Excerpt: At least 80% of the mutations had a significant negative effect on fitness, whereas none of the mutations had a significant positive effect. http://www.springerlink.com/content/r37w1hrq5l0q3832/
High Frequency of Cryptic Deleterious Mutations in Caenorhabditis elegans ( Esther K. Davies, Andrew D. Peters, Peter D. Keightley)
"In fitness assays, only about 4 percent of the deleterious mutations fixed in each line were detectable. The remaining 96 percent, though cryptic, are significant for mutation load...the presence of a large class of mildly deleterious mutations can never be ruled out. "
But in all the reading Ive done in the life-sciences literature, Ive never found a mutation that added information All point mutations that have been studied on the molecular level turn out to reduce the genetic information and not increase it.
Lee Spetner - Ph.D. Physics - MIT - (Not By Chance: Shattering the Modern Theory of Evolution)
"Bergman (2004) has studied the topic of beneficial mutations. Among other things, he did a simple literature search via Biological Abstracts and Medline. He found 453,732 mutation hits, but among these only 186 mentioned the word beneficial (about 4 in 10,000). When those 186 references were reviewed, almost all the presumed beneficial mutations were only beneficial in a very narrow sense- but each mutation consistently involved loss of function changes-hence loss of information. Sanford: Genetic Entropy
Mutations, in summary, tend to induce sickness, death, or deficiencies. No evidence in the vast literature of heredity change shows unambiguous evidence that random mutation itself, even with geographical isolation of populations leads to speciation.
Lynn Margulis - Acquiring Genomes , p. 29.
But there is no evidence that DNA mutations can provide the sorts of variation needed for evolution There is no evidence for beneficial mutations at the level of macroevolution, but there is also no evidence at the level of what is commonly regarded as microevolution.
Jonathan Wells (PhD. - Molecular Biology)
Evolution vs. Genetic Entropy - video
Intelligent Design - The Anthropic Hypothesis