Simulations reveal new information about the gateway to the cell nucleus
Excerpt: “There are whole machines in living cells that are made of hundreds or thousands of proteins,” says Schulten, “and the nuclear pore is one of those systems. It’s actually one of the most magnificent systems in the cell.”,,,Hundreds to thousands of NPCs are embedded in the nuclear envelope of each cell,"... http://www.psc.edu/science/2006/schulten/
Excerpt: Nuclear pores allow the transport of water-soluble molecules across the nuclear envelope. This transport includes RNA and ribosomes moving from nucleus to the cytoplasm and proteins (such as DNA polymerase and lamins), carbohydrates, signal molecules and lipids moving into the nucleus. It is notable that the nuclear pore complex (NPC) can actively conduct 1000 translocations per complex per second.
The Nuclear Pore Complex - Gateway to the Nucleus
Excerpt: The nuclear pore complex (NPC), perhaps the largest protein complex in the cell, is responsible for the protected exchange of components between the nucleus and cytoplasm and for preventing the transport of material not destined to cross the nuclear envelope.
The nuclear pore complex becomes alive: new insights into its dynamics and involvement in different cellular processes
Excerpt: In this review we summarize the structure and function of the nuclear pore complex (NPC). Special emphasis is put on recent findings which reveal the NPC as a dynamic structure in the context of cellular events like nucleocytoplasmic transport, cell division and differentiation, stress response and apoptosis. Evidence for the involvement of nucleoporins in transcription and oncogenesis is discussed,,,
The Cell as a Collection of Protein Machines
"We have always underestimated cells. Undoubtedly we still do today,,, Indeed, the entire cell can be viewed as a factory that contains an elaborate network of interlocking assembly lines, each which is composed of a set of large protein machines."
Bruce Alberts: Former President, National Academy of Sciences;
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