The aliens have returned to Earth yet again, messing up Duke's sweet routine of dirty leisure. The alien invaders are stealing Earth's women and they drank Duke's beer. As Duke battles his way through waves of aliens, the once-beautiful gambling haven and Duke Nukem franchise chains are crumbling before his eyes. You are given access to an arsenal of over-the-top weapons, nonstop action, and numerous levels of interactivity. Shoot hoops, lift weights, read adult magazines, draw crude messages on whiteboards, or ogle the many women that occupy Duke's life; that is, if you can pull yourself away from destroying alien invaders.