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A genetic engineering student tries to bring back the skills of a legend of the past and use his skills to save India from a deadly virus attack by China.
The film depicts the fictional life of Bodhidharma (Suriya), a master of martial arts and medical remedies, who is depicted in the film as the son of a great Tamil king of the Pallava Dynasty. He is sent to China by his guru, who requests him to stop the spread of a pandemic disease existing there from spreading to India. Initially the people in China treated him as an inferior but later when he cures a little girl from the deadly disease and fights against some people who ill treated villagers there, the people of China began to respect and worship him. He begins to teach them how to cure many diseases, the skills of hypnotism and the physical training of the Shaolin monks that led to the creation of Shaolinquan. However after few years, when he expresses his desire to return to India, the villagers plot to poison him and bury him near the temple, believing that their place would be disease free if he is buried there. Bodhidharma agrees to die and subsequently becomes a fundamental figure in Chinese history, affectionately being dubbed as "Damo".
The film switches to modern day China, where Dong Lee (Johnny Tri Nguyen) is given the task of starting a government planned biological war against India, known as Operation Red. Dong Lee starts this operation by injecting a virus into a street dog. This disease was the one which occurred during the time of Bodhidharma in China. Meanwhile Subha Srinivasan (Shruti Haasan) researched that Bodhidharma can be brought back to life if his sample of DNA is matched with another sample of DNA which she finds in Aravind (Suriya) a descendant of Bodhidharma who is working as Circus artist in Chennai. Shuba tries to give life to Bodhidharma to end the menace of Dong Lee. But Dong Lee, who is capable of doing anything, does all impossibly bad things, mastered in 'Nokku Varmam' (Hypnotism), a martial art which was actually taught to the Chinese by Bodhidharma. Subha with the help of her friends from her genetic department tries to activate the Bodhidharma DNA in Aravind in a research centre. But Dong Lee traces Subha and her friends with the help of Subha's professor who had received a huge sum of money from the China government. But after Dong Lee traces them he then kills the professor. Dong Lee then locates the place of the research centre. Subha and her friends in the research centre try to escape in a van but Dong Lee chases them and the van collapses. Aravind gets beaten badily by Dong Lee at first, but then Arvind manages to regain Bodhidharma skills somehow in spite of the sunrays hitting him on his face which was not supposed to happen and a day before he was estimated to regain his skills. Then Aravind gets Bodhidharma's talent and defeats Dong Lee. Finally, Aravind eradicates the virus spreading. The film ends with him giving a lecture about the need for us to remember our history and to teach all our practices in the name of science and not god.