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Just Folding One Single Protein Molecule, of which your body has countless trillions, would take a few hundred thousand computers weeks to accomplish. - Evolution vs. Functional Proteins - Doug Axe - Video *******www.youtube****/watch?v=M4FvdOxIDfU In real life, the protein folds into its final shape in a fraction of a second! The Blue Gene computer would have to operate at least 33 million times faster to accomplish what the protein does in a fraction of a second. This is the complexity found for JUST ONE simple protein molecule. Yet, evolution must account for the origination of far, far, more than just one specifically sequenced protein molecule: A New Guide to Exploring the Protein Universe "It is estimated, based on the total number of known life forms on Earth, that there are some 50 billion different types of proteins in existence today, and it is possible that the protein universe could hold many trillions more." Lynn Yarris - 2005 *******www.lbl.gov/Science-Articles/Archive/sabl/2005/March/02-protein-universe.html Michael Behe Talks About The Probability of A Single Protein - video *******www.youtube****/watch?v=WTvbp_oRFwM Origin Of Life? Where Does The Evidence Lead? - video *******www.youtube****/watch?v=1VM_bYKRRxg What makes matters much worse for the materialist is that he will try to assert proteins of one structure can easily mutate into other proteins, of a completely different structure, by pure chance. Yet once again the empirical evidence we now have brutally betrays the materialist. Individual proteins have been experimentally shown to quickly lose their structural integrity with random point mutations. What are the odds of any "functional protein domain" in a cell mutating into any other functional protein domain, of very questionable value, by pure chance? Estimating the prevalence of protein sequences adopting functional enzyme folds: Doug Axe: Excerpt: Starting with a weakly functional sequence carrying this signature, clusters of ten side-chains within the fold are replaced randomly, within the boundaries of the signature, and tested for function. The prevalence of low-level function in four such experiments indicates that roughly one in 10^64 signature-consistent sequences forms a working domain. Combined with the estimated prevalence of plausible hydropathic patterns (for any fold) and of relevant folds for particular functions, this implies the overall prevalence of sequences performing a specific function by any domain-sized fold may be as low as 1 in 10^77, adding to the body of evidence that functional folds require highly extraordinary sequences. (of note: the universe only has 10^80 sub-atomic particles) *******www.ncbi.nlm.nih.gov/pubmed/15321723 Axe Diagram for finding a functional protein domain out of all sequence space: The y-axis can be seen as representing enzyme activity, and the x-axis represents all possible amino acid sequences. Enzymes sit at the peak of their fitness landscapes (Point A). There are extremely high levels of complex and specified information in proteins--informational sequences which point to intelligent design. *******www.evolutionnews****/axediagram.jpg Experimental Support for Regarding Functional Classes of Proteins to be Highly Isolated from Each Other: "From actual experimental results it can easily be calculated that the odds of finding a folded protein (by random point mutations to an existing protein) are about 1 in 10 to the 65 power (Sauer, MIT). To put this fantastic number in perspective imagine that someone hid a grain of sand, marked with a tiny 'X', somewhere in the Sahara Desert. After wandering blindfolded for several years in the desert you reach down, pick up a grain of sand, take off your blindfold, and find it has a tiny 'X'. Suspicious, you give the grain of sand to someone to hide again, again you wander blindfolded into the desert, bend down, and the grain you pick up again has an 'X'. A third time you repeat this action and a third time you find the marked grain. The odds of finding that marked grain of sand in the Sahara Desert three times in a row are about the same as finding one new functional protein structure (from chance transmutation of an existing functional protein structure). Rather than accept the result as a lucky coincidence, most people would be certain that the game had been fixed. Michael J. Behe, The Weekly Standard, June 7, 1999 *******www.arn****/docs/behe/mb_smu1992.htm Intelligent Design - The Anthropic Hypothesis *******lettherebelight-77.blogspot****/
6 Apr 2011
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9:45
The “real work” of the beginning of the Cambrian Explosion may in actuality be as short as a two to three million year time frame (Hugh Ross, Jonathan Wells) which is well within what is termed the "geologic resolution time" i.e. The time frame for the main part of the Cambrian Explosion apparently can't be shortened any further due to limitations of our accurately dating this ancient time period more precisely. "The Cambrian Explosion was so short that it is below the resolution of the fossil record. It could have happened overnight. So we don't know the duration of the Cambrian Explosion. We just know that it was very, very, fast." Jonathan Wells - Darwin's Dilemma Quote Darwin's Dilemma Trailer - Excellent Cambrian Explosion Movie Now Available On DVD - Sept. 2009 *******www.illustramedia****/ddinfo.htm Genesis 1:20 Then God said, "Let the waters teem with swarms of living creatures,",,, Investigating Evolution: The Cambrian Explosion Part 1 - video *******www.youtube****/watch?v=4DkbmuRhXRY Part 2 - video *******www.youtube****/watch?v=iZFM48XIXnk The Cambrian Sea - video *******www.youtube****/watch?v=O8UXlcgzcEA The scant "track" evidence for worms in the pre-Cambrian has now been brought into question: Discovery Of Giant Roaming Deep Sea Protist Provides New Perspective On Animal Evolution: Excerpt: This is the first time a single-celled organism has been shown to make such animal-like traces. The finding is significant, because similar fossil grooves and furrows found from the Precambrian era, as early as 1.8 billion years ago, have always been attributed to early evolving multicellular animals. "If our giant protists were alive 600 million years ago and the track was fossilized, a paleontologist unearthing it today would without a shade of doubt attribute it to a kind of large, multicellular, bilaterally symmetrical animal," says Matz, an assistant professor of integrative biology. "We now have to rethink the fossil record." *******www.sciencedaily****/releases/2008/11/081120130531.htm Interestingly, "simple" Jellyfish and Sponges appeared suddenly in the fossil record a few ten million years before the Cambrian Explosion, and have remained virtually unchanged since they first appeared in the fossil record. Moreover, contrary to evolutionary thinking, Jellyfish and Sponges appear to have essential purpose in preparing the ecosystem for the Cambrian Explosion that was to follow. Marine animals cause a stir - July 2009 Excerpt: Kakani Katija and John Dabiri used field measurements of jellyfish swimming in a remote island lake, combined with a new theoretical model, to demonstrate that the contribution of living organisms to ocean mixing via this mechanism is substantial — of the same order of magnitude as winds and tides. (Winds and tides, due to their prevention of stagnation, are known to be essential for life on earth.) *******www.nature****/nature/journal/v460/n7255/edsumm/e090730-08.html Sponges Determine Coral Reef's Nutrient Cycle Excerpt: Sponges, which have worldwide distribution in the oceans, filter water. They take up planktonic particles such as bacteria and excrete inorganic nutrients. In turn, these nutrients can facilitate the growth of marine plants and other organisms. Sponges filter water at a phenomenal rate: if the seawater were to remain stationary, the sponges would have completely pumped it away within five minutes,,,, these organisms play a key role in the marine nutrient cycle due to their incredible capacity to convert enormous quantities of organic plankton into inorganic material (nutrients). *******www.sciencedaily****/releases/2005/09/050917085649.htm Fossils of all types of sponges alive today have been found virtually unchanged in rocks dated from 580 to 523 million years ago. Sponges with photosynthesizing endosymbionts produce up to three times more oxygen than they consume, as well as more organic matter than they consume. (Wikipedia) Barrel and Chimney Sponges Filtering Water - video *******www.youtube****/watch?v=T7E1rq7zHLc My guess is that, as with photosynthetic bacteria, sulfate reducing bacteria, sponges, and jellyfish, Ediacara biota will ultimately be found to have a essential biogeochemical role in preparing the earth for more advanced life to appear in the Cambrian explosion. Evolution vs. Functional Proteins - Doug Axe - Video *******www.metacafe****/watch/4018222/evolution_vs_functional_proteins_where_did_the_information_come_from_doug_axe_stephen_meyer/ Stephen Meyer - Functional Proteins And Information For Body Plans - video *******www.metacafe****/watch/4050681/stephen_meyer_functional_proteins_and_information_for_body_plans/ Conservation Of Transcendent Information - 2007 - video *******www.metacafe****/watch/3995275/intelligent_design_conservation_of_transcendent_information/ Scientific Evidence For God (Logos) Creating The Universe - 2008 - video *******www.metacafe****/watch/3995300/scientific_evidence_for_god_logos_creating_the_universe/ Intelligent Design - The Anthropic Hypothesis *******lettherebelight-77.blogspot****/
8 Mar 2011
6628
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6:07
Contrary to the "unpleasant" aversion Dawkins has for "a particular" Intelligent Design inference, there are actually multiple lines of evidence for concretely making the inference to intelligent design. Even the transcendent Theistic "designer" that Dawkins seems to detest so much. The DNA Code - Solid Scientific Proof Of Intelligent Design - Perry Marshall - video *******www.metacafe****/watch/4060532/the_dna_code_solid_scientific_proof_of_intelligent_design_perry_marshall/ Scientific Evidence For God (Logos) Creating The Universe - 2008 - video *******www.metacafe****/watch/3995300/scientific_evidence_for_god_logos_creating_the_universe/ Explaining Information Transfer in Quantum Teleportation: Armond Duwell †‡ University of Pittsburgh Excerpt: In contrast to a classical bit, the description of a qubit requires an infinite amount of information. The amount of information is infinite because two real numbers are required in the expansion of the state vector of a two state quantum system (Jozsa 1997, 1) --- Concept 2. is used by Bennett, et al. Recall that they infer that since an infinite amount of information is required to specify a qubit, an infinite amount of information must be transferred to teleport. *******www.cas.umt.edu/phil/faculty/duwell/DuwellPSA2K.pdf Evolution's Fatal Flaw - The Origin Of Life - Chris Ashcraft PhD - video *******www.youtube****/watch?v=OQks3COscX4 "No man-made program comes close to the technical brilliance of even Mycoplasmal genetic algorithms. Mycoplasmas are the simplest known organism with the smallest known genome, to date. How was its genome and other living organisms' genomes programmed?" - David L. Abel and Jack T. Trevors, “Three Subsets of Sequence Complexity and Their Relevance to Biopolymeric Information,” Theoretical Biology & Medical Modelling, Vol. 2, 11 August 2005, page 8 *******www.biomedcentral****/content/pdf/1742-4682-2-29.pdf Evolution vs. Functional Proteins - Doug Axe - Video *******www.metacafe****/watch/4018222/evolution_vs_functional_proteins_where_did_the_information_come_from_doug_axe_stephen_meyer/ A Few Hundred Thousand Computers vs. A Single Protein Molecule - video *******www.metacafe****/watch/4018233/a_single_protein_molecule_vs_a_few_hundred_thousand_computers/ Stephen Meyer is interviewed about the "information problem" in DNA, Signature in the Cell - video *******downloads.cbn****/cbnnewsplayer/cbnplayer.swf?aid=8497 Stephen C. Meyer - Signature In The Cell: "DNA functions like a software program," "We know from experience that software comes from programmers. Information--whether inscribed in hieroglyphics, written in a book or encoded in a radio signal--always arises from an intelligent source. So the discovery of digital code in DNA provides evidence that the information in DNA also had an intelligent source." *******www.evolutionnews****/2009/07/leading_advocate_of_intelligen.html Physicists Finding Perfection… in Biology — June 1st, 2009 by Biologic Staff Excerpt: "biological processes tend to be optimal in cases where this can be tested." *******biologicinstitute****/2009/06/01/physicists-finding-perfection-in-biology/ Anthropic Principle - God Created The Universe - Michael Strauss - video *******www.metacafe****/watch/4003932/anthropic_principle_god_created_the_universe_michael_strauss_phd/ Fine Tuning Of Dark Energy and Mass of the Universe - Hugh Ross - video *******www.metacafe****/watch/4007682/the_fine_tuning_of_dark_energy_and_the_mass_of_the_universe/ Does God Exist? The End Of Christianity - Finding a Good God in an Evil World - video *******www.metacafe****/watch/4007708/does_god_exist_finding_a_good_god_in_an_evil_world/ Probability For Life On Earth - Michael Strauss - video *******www.metacafe****/watch/4007729/probability_for_life_on_any_planet_like_earth_michael_strauss_phd/ The Privileged Planet - video *******video.google****/videoplay?docid=5488284265590289530 Probability For Life On Earth - List of Parameters, References, and Math - Hugh Ross *******www.reasons****/probability-life-earth-apr-2004 *******www.johnankerberg****/Articles/_PDFArchives/science/SC2W0304RFT.pdf Intelligent Design - The Anthropic Hypothesis *******lettherebelight-77.blogspot****/
17 Oct 2011
4577
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9:59
Donald E. Johnson Bibliography *******www.amazon****/Donald-E.-Johnson/e/B001K8LWHQ Dr. Johnson's website: Science Integrity - Exposing Unsubstantiated Science Claims *******scienceintegrity****/PNNP.aspx *******scienceintegrity****/default.aspx DNA: The Tiny Code That's Toppling Evolution Excerpt: The DNA molecule carries the genetic language, but the language itself is independent of its carrier. The same genetic information can be written in a book, stored in a compact disk or sent over the Internet, and yet the quality or content of the message has not changed by changing the means of conveying it. *******www.gnmagazine****/issues/gn58/tinycode.htm ‘DNA computer’ cracks code - 2002 Excerpt: A ‘DNA computer’ has been used for the first time to find the only correct answer from over a million possible solutions to a computational problem. *******physicsworld****/cws/article/news/5229 Donald Johnson video lecture: *******www.ideaclubtcw****/video/DEJohnson.html Mathematically Defining Functional Information In Molecular Biology - Kirk Durston - short video *******www.metacafe****/watch/3995236/mathematically_defining_functional_information_in_molecular_biology_kirk_durston/ Entire video: *******vimeo****/1775160 The Capabilities of Chaos and Complexity: David L. Abel - Null Hypothesis For Information Generation - 2009 To focus the scientific community’s attention on its own tendencies toward overzealous metaphysical imagination bordering on “wish-fulfillment,” we propose the following readily falsifiable null hypothesis, and invite rigorous experimental attempts to falsify it: "Physicodynamics cannot spontaneously traverse The Cybernetic Cut: physicodynamics alone cannot organize itself into formally functional systems requiring algorithmic optimization, computational halting, and circuit integration." A single exception of non trivial, unaided spontaneous optimization of formal function by truly natural process would falsify this null hypothesis. *******www.mdpi****/1422-0067/10/1/247/pdf *******mdpi****/1422-0067/10/1/247/ag The digital code of DNA - 2003 - Leroy Hood & David Galas The discovery of the structure of DNA transformed biology profoundly, catalysing the sequencing of the human genome and engendering a new view of biology as an information science. Two features of DNA structure account for much of its remarkable impact on science: its digital nature and its complementarity, whereby one strand of the helix binds perfectly with its partner. DNA has two types of digital information — the genes that encode proteins, which are the molecular machines of life, and the gene regulatory networks that specify the behaviour of the genes. *******www.nature****/nature/journal/v421/n6921/full/nature01410.html Stephen Meyer is interviewed about the "information problem" in DNA, Signature in the Cell - video *******downloads.cbn****/cbnnewsplayer/cbnplayer.swf?aid=8497 The DNA Code - Solid Scientific Proof Of Intelligent Design - Perry Marshall - video *******www.metacafe****/watch/4060532/the_dna_code_solid_scientific_proof_of_intelligent_design_perry_marshall/ Evolution vs. Functional Proteins - Doug Axe - Video *******www.metacafe****/watch/4018222/evolution_vs_functional_proteins_where_did_the_information_come_from_doug_axe_stephen_meyer/ "Phosphatase speeds up reactions vital for cell signalling by 10^21 times. Allows essential reactions to take place in a hundreth of a second; without it, it would take a trillion years!" Jonathan Sarfati *******www.pnas****/content/100/10/5607.abstract Building a Cell: Staggering Complexity: - Feb. 2010 Excerpt: “All organisms, from bacteria to humans, face the daunting task of replicating, packaging and segregating up to two metres (about 6 x 10^9 base pairs) of DNA when each cell divides,” “,,,the segregation machinery must function with far greater accuracy than man-made machines and with an exquisitely soft touch to prevent the DNA strands from breaking.” Bloom and Joglekar talked “machine language” over and over. The cell has specialized machines for all kinds of tasks: segregation machines, packaging machines, elaborate machines, streamlined machines, protein translocation machines, DNA-processing machines, DNA-translocation machines, robust macromolecular machines, accurate machines, ratchets, translocation pumps, mitotic spindles, DNA springs, coupling devices, and more. The authors struggle to “understand how these remarkable machines function with such exquisite accuracy.” *******www.creationsafaris****/crev201002.htm#20100202a Evolution vs ATP Synthase - Molecular Machine - video *******www.metacafe****/watch/4012706/evolution_vs_atp_synthase_molecular_machine/ "No man-made program comes close to the technical brilliance of even Mycoplasmal genetic algorithms. Mycoplasmas are the simplest known organism with the smallest known genome, to date. How was its genome and other living organisms' genomes programmed?" - David L. Abel and Jack T. Trevors, “Three Subsets of Sequence Complexity and Their Relevance to Biopolymeric Information,” Theoretical Biology & Medical Modelling, Vol. 2, 11 August 2005, page 8 *******www.biomedcentral****/content/pdf/1742-4682-2-29.pdf “The problem of the origin of life is clearly basically equivalent to the problem of the origin of biological information.” Origin of life theorist Bernd-Olaf Kuppers in his book "Information and the Origin of Life" Intelligent Design - The Anthropic Hypothesis *******lettherebelight-77.blogspot****/
14 Mar 2010
8098
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10:00
Richard Sternberg's website: *******www.richardsternberg****/ Waiting Longer for Two Mutations, Part 5 - Michael Behe Excerpt: the appearance of a particular (beneficial) double mutation in humans would have an expected time of appearance of 216 million years, *******behe.uncommondescent****/2009/03/waiting-longer-for-two-mutations-part-5/ Whale Evolution? - Exposing The Deception - video *******www.metacafe****/watch/4032568/whale_evolution_exposing_the_deception_in_the_fossil_record_dr_terry_mortenson/ Whale Tale Two Excerpt: We think that the most logical interpretation of the Pakicetus fossils are that they represent land-dwelling mammals that didn’t even have teeth or ears in common with modern whales. This actually pulls the whale evolution tree out by the roots. Evolutionists are back to the point of not having any clue as to how land mammals could possibly have evolved into whales. *******www.ridgecrest.ca.us/~do_while/sage/v6i2f.htm What Does It take To Change A Cow Into A Whale - David Berlinski - video *******www.youtube****/watch?v=DRqdvhL3pgM Chimpanzee? 10-10-2008 - Dr Richard Buggs - research geneticist at the University of Florida ...Therefore the total similarity of the genomes could be below 70%. *******www.refdag.nl/artikel/1366432/Chimpanzee.html Estimating the prevalence of protein sequences adopting functional enzyme folds: Doug Axe: Excerpt: Starting with a weakly functional sequence carrying this signature, clusters of ten side-chains within the fold are replaced randomly, within the boundaries of the signature, and tested for function. The prevalence of low-level function in four such experiments indicates that roughly one in 10^64 signature-consistent sequences forms a working domain. Combined with the estimated prevalence of plausible hydropathic patterns (for any fold) and of relevant folds for particular functions, this implies the overall prevalence of sequences performing a specific function by any domain-sized fold may be as low as 1 in 10^77, adding to the body of evidence that functional folds require highly extraordinary sequences. *******www.ncbi.nlm.nih.gov/pubmed/15321723 Evolution vs. Functional Proteins - Doug Axe - Video *******www.metacafe****/watch/4018222/evolution_vs_functional_proteins_where_did_the_information_come_from_doug_axe_stephen_meyer/ Chimps are not like humans - May 2004 Excerpt: the International Chimpanzee Chromosome 22 Consortium reports that 83% of chimpanzee chromosome 22 proteins are different from their human counterparts,,, The results reported this week showed that "83% of the genes have changed between the human and the chimpanzee—only 17% are identical—so that means that the impression that comes from the 1.2% [sequence] difference is [misleading]. In the case of protein structures, it has a big effect," Sakaki said. *******cmbi.bjmu.edu.cn/news/0405/119.htm Eighty percent of proteins are different between humans and chimpanzees; Gene; Volume 346, 14 February 2005: *******www.ncbi.nlm.nih.gov/pubmed/15716009 Stephen Meyer - Functional Proteins And Information For Body Plans - video *******www.metacafe****/watch/4050681/stephen_meyer_functional_proteins_and_information_for_body_plans/ The Paradox of the "Ancient" Bacterium Which Contains "Modern" Protein-Coding Genes: “Almost without exception, bacteria isolated from ancient material have proven to closely resemble modern bacteria at both morphological and molecular levels.” Heather Maughan*, C. William Birky Jr., Wayne L. Nicholson, William D. Rosenzweig§ and Russell H. Vreeland ; *******mbe.oxfordjournals****/cgi/content/full/19/9/1637 Mutation Studies, Videos, And Quotes *******docs.google****/Doc?docid=0AYmaSrBPNEmGZGM4ejY3d3pfMjZjZnM5M21mZg Simulating evolution by gene duplication of protein features that require multiple amino acid residues: Michael J. Behe and David W. Snoke Excerpt: We conclude that, in general, to be fixed in 10^8 generations, the production of novel protein features that require the participation of two or more amino acid residues simply by multiple point mutations in duplicated genes would entail population sizes of no less than 10^9.,,,The fact that very large population sizes—10^9 or greater—are required to build even a minimal [multi-residue] feature requiring two nucleotide alterations within 10^8 generations by the processes described in our model, and that enormous population sizes are required for more complex features or shorter times, seems to indicate that the mechanism of gene duplication and point mutation alone would be ineffective, at least for multicellular diploid species, because few multicellular species reach the required population sizes. *******www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2286568 Evolution Cartoon - Waiting For That Beneficial Mutation - video *******www.youtube****/watch?v=71-QYtxi8Bw Intelligent Design - The Anthropic Hypothesis *******lettherebelight-77.blogspot****/
3 May 2010
26100
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7:52
Though evolutionists pretend that the evolution of such a complex structure as the eye is no big deal, the fact is that they cannot account for the origination of even one protein molecule that is in this irreducibly complex pathway for sight: Evolution vs. Functional Proteins - Doug Axe - Video *******www.metacafe****/watch/4018222/evolution_vs_functional_proteins_where_did_the_information_come_from_doug_axe_stephen_meyer/ Axe Diagram for finding a functional protein domain out of all sequence space: The y-axis can be seen as representing enzyme activity, and the x-axis represents all possible amino acid sequences. Enzymes sit at the peak of their fitness landscapes (Point A). There are extremely high levels of complex and specified information in proteins--informational sequences which point to intelligent design. *******www.evolutionnews****/axediagram.jpg "a very rough but conservative result is that if all the sequences that define a particular (protein) structure or fold-set where gathered into an area 1 square meter in area, the next island would be tens of millions of light years away." Kirk Durston Peptide synthesis "typically peptides and proteins in the range of 70~100 amino acids are pushing the limits of synthetic accessibility. Synthetic difficulty also is sequence dependent; typically amyloid peptides and proteins are difficult to make."(To make larger proteins requires “non-natural” peptide bonds - (Chemical Synthesis Of Proteins - 2005)) *******en.wikipedia****/wiki/Peptide_synthesis As a Theist I am very much interested as to exactly what in the brain is actually doing the "seeing": Dr. Quantum - Double Slit Experiment & Entanglement - video *******www.metacafe****/watch/4096579/dr_quantum_double_slit_experiment_entanglement/ That the "mind" of a individual observer would play such an integral yet not complete "closed system role", in the instantaneous quantum wave collapse of the universe to "3D centrality", gives us clear evidence that our "mind" is a unique entity. A unique entity with a superior quality of existence when compared to the "uncertain 3D particles" of the "material" universe. This is clear evidence for the existence of the "higher dimensional soul" of man that supersedes any "material basis" that the soul/mind has been purported to "emerge" from by materialists. The Known Universe - Dec. 2009 - very cool video (please note the centrality of the earth in the universe) *******www.youtube****/v/17jymDn0W6U of note: The only way to "geometrically" maintain continuous 3D spherical symmetry of the Cosmic Microwave Background Radiation within the "3D universe", from different points of observation in the universe, is for all the "higher dimensional" quantum waves of the universe to collapse to their "uncertain" 3D particle state, universally and instantaneously, for/to each individual observer in the universe. *******en.wikipedia****/wiki/Symmetry_in_physics Blind Woman Can See During Near Death Experience - Pim Lommel - video *******www.metacafe****/watch/3994599/blind_woman_can_see_during_near_death_experience_pim_lommel_nde/ Kenneth Ring and Sharon Cooper (1997) conducted a study of 31 blind people, many of who reported vision during their NDEs. 21 of these people had had an NDE while the remaining 10 had had an out-of-body experience (OBE), but no NDE. It was found that in the NDE sample, about half had been blind from birth. *******findarticles****/p/articles/mi_m2320/is_1_64/ai_65076875/ In The Wonder Of Being Human: Our Brain and Our Mind, Eccles and Robinson discussed the research of three groups of scientists (Robert Porter and Cobie Brinkman, Nils Lassen and Per Roland, and Hans Kornhuber and Luder Deeke), all of whom produced startling and undeniable evidence that a "mental intention" preceded an actual neuronal firing - thereby establishing that the mind is not the same thing as the brain, but is a separate entity altogether. *******books.google****/books?id=J9pON9yB8HkC&pg=PT28&lpg=PT28 The Miracle Of Eyesight *******docs.google****/Doc?docid=0AYmaSrBPNEmGZGM4ejY3d3pfMThmd25mdjRocQ Intelligent Design - The Anthropic Hypothesis *******lettherebelight-77.blogspot****/
7 Mar 2010
14660
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8:28
"Information is information, not matter or energy. No materialism which does not admit this can survive at the present day." Norbert Weiner - MIT Mathematician - Father of Cybernetics Materialists have tried to get around this crushing evidence for the sudden appearance of life by suggesting life could originate in extreme conditions. Yet they are betrayed once again by the empirical evidence: Refutation Of Hyperthermophile Origin Of Life scenario Excerpt: While life, if appropriately designed, can survive under extreme physical and chemical conditions, it cannot originate under those conditions. High temperatures are especially catastrophic for evolutionary models. The higher the temperature climbs, the shorter the half-life for all the crucial building block molecules, *******www.reasons****/LateHeavyBombardmentIntensityandtheOriginofLife Chemist explores the membranous origins of the first living cell: Excerpt: Conditions in geothermal springs and similar extreme environments just do not favor membrane formation, which is inhibited or disrupted by acidity, dissolved salts, high temperatures, and calcium, iron, and magnesium ions. Furthermore, mineral surfaces in these clay-lined pools tend to remove phosphates and organic chemicals from the solution. "We have to face up to the biophysical facts of life," Deamer said. "Hot, acidic hydrothermal systems are not conducive to self-assembly processes." *******currents.ucsc.edu/05-06/04-03/deamer.asp The evidence scientists have discovered in the geologic record is stunning in its support of the anthropic hypothesis. The oldest sedimentary rocks on earth, known to science, originated underwater (and thus in relatively cool environs) 3.86 billion years ago. Those sediments, which are exposed at Isua in southwestern Greenland, also contain the earliest chemical evidence (fingerprint) of “photosynthetic” life [Nov. 7, 1996, Nature]. This evidence had been fought by materialists since it is totally contrary to their evolutionary theory. Yet, Danish scientists were able to bring forth another line of geological evidence to substantiate the primary line of geological evidence for photo-synthetic life in the earth’s earliest sedimentary rocks (U-rich Archaean sea-floor sediments from Greenland - indications of +3700 Ma oxygenic photosynthesis (2003). Thus we now have conclusive evidence for photo-synthetic life in the oldest sedimentary rocks ever found by scientists on earth. The simplest photosynthetic bacterial life on earth is exceedingly complex, too complex to happen by accident even if the primeval oceans had been full of pre-biotic soup. The Miracle Of Photosynthesis - electron transport - video *******www.youtube****/watch?v=hj_WKgnL6MI Evolution vs ATP Synthase - Molecular Machine - video *******www.metacafe****/watch/4012706/evolution_vs_atp_synthase_molecular_machine/ Electron transport and ATP synthesis during photosynthesis - Illustration *******www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=cooper.figgrp.1672 Evolutionary biology: Out of thin air John F. Allen & William Martin: The measure of the problem is here: “Oxygenetic photosynthesis involves about 100 proteins that are highly ordered within the photosynthetic membranes of the cell." *******www.nature****/nature/journal/v445/n7128/full/445610a.html Estimating the prevalence of protein sequences adopting functional enzyme folds: Doug Axe: Excerpt: Starting with a weakly functional sequence carrying this signature, clusters of ten side-chains within the fold are replaced randomly, within the boundaries of the signature, and tested for function. The prevalence of low-level function in four such experiments indicates that roughly one in 10^64 signature-consistent sequences forms a working domain. Combined with the estimated prevalence of plausible hydropathic patterns (for any fold) and of relevant folds for particular functions, this implies the overall prevalence of sequences performing a specific function by any domain-sized fold may be as low as 1 in 10^77, adding to the body of evidence that functional folds require highly extraordinary sequences. *******www.ncbi.nlm.nih.gov/pubmed/15321723 Evolution vs. Functional Proteins - Doug Axe - Video *******www.metacafe****/watch/4018222/evolution_vs_functional_proteins_where_did_the_information_come_from_doug_axe_stephen_meyer/ Of note: anoxygenic (without oxygen) photosynthesis is even more of a complex chemical pathway than oxygenic photosynthesis is: "Remarkably, the biosynthetic routes needed to make the key molecular component of anoxygenic photosynthesis are more complex than the pathways that produce the corresponding component required for the oxygenic form."; Hugh Ross also of note: Anaerobic organisms and most viruses are quickly destroyed by direct contact with oxygen. "There is no question about photosynthesis being Irreducibly Complex. But it’s worse than that from an evolutionary perspective. There are 17 enzymes alone involved in the synthesis of chlorophyll. Are we to believe that all intermediates had selective value? Not when some of them form triplet states that have the same effect as free radicals like O2. In addition if chlorophyll evolved before antenna proteins, whose function is to bind chlorophyll, then chlorophyll would be toxic to cells. Yet the binding function explains the selective value of antenna proteins. Why would such proteins evolve prior to chlorophyll? and if they did not, how would cells survive chlorophyll until they did?" Uncommon Descent Blogger Interestingly, while the photo-synthetic bacteria were reducing greenhouse gases and producing oxygen, and metal, and minerals, which would all be of benefit to modern man, "sulfate-reducing" bacteria were also producing their own natural resources which would be very useful to modern man. Sulfate-reducing bacteria helped prepare the earth for advanced life by detoxifying the primeval earth and oceans of poisonous levels of heavy metals while depositing them as relatively inert metal ores. Metal ores which are very useful for modern man, as well as fairly easy for man to extract today (mercury, cadmium, zinc, cobalt, arsenic, chromate, tellurium and copper to name a few). To this day, sulfate-reducing bacteria maintain an essential minimal level of these heavy metals in the ecosystem which are high enough so as to be available to the biological systems of the higher life forms that need them yet low enough so as not to be poisonous to those very same higher life forms. Bacterial Heavy Metal Detoxification and Resistance Systems: Excerpt: Bacterial plasmids contain genetic determinants for resistance systems for Hg2+ (and organomercurials), Cd2+, AsO2, AsO43-, CrO4 2-, TeO3 2-, Cu2+, Ag+, Co2+, Pb2+, and other metals of environmental concern. *******www.springerlink****/content/u1t281704577v8t3/ *******www.int-res****/articles/meps/26/m026p203.pdf Even this recent "evolution friendly" article readily admits the staggering level of complexity required for the "first" cell: Was our oldest ancestor a proton-powered rock? - Oct. 2009 Excerpt: “There is no doubt that the progenitor of all life on Earth, the common ancestor, possessed DNA, RNA and proteins, a universal genetic code, ribosomes (the protein-building factories), ATP and a proton-powered enzyme for making ATP. The detailed mechanisms for reading off DNA and converting genes into proteins were also in place. In short, then, the last common ancestor of all life looks pretty much like a modern cell.” *******www.newscientist****/article/mg20427306.200-was-our-oldest-ancestor-a-protonpowered-rock.html Journey Inside The Cell - DNA to mRNA to Proteins - Stephen Meyer - Signature In The Cell - video *******www.youtube****/watch?v=1fiJupfbSpg Signature in the Cell - Book Review - Ken Peterson Excerpt: the “simplest extant cell, Mycoplasma genitalium — a tiny bacterium that inhabits the human urinary tract — requires ‘only’ 482 proteins to perform its necessary functions…(562,000 bases of DNA…to assemble those proteins).” ,,, amino acids have to congregate in a definite specified sequence in order to make something that “works.” First of all they have to form a “peptide” bond and this seems to only happen about half the time in experiments. Thus, the probability of building a chain of 150 amino acids containing only peptide links is about one chance in 10 to the 45th power. In addition, another requirement for living things is that the amino acids must be the “left-handed” version. But in “abiotic amino-acid production” the right- and left-handed versions are equally created. Thus, to have only left-handed, only peptide bonds between amino acids in a chain of 150 would be about one chance in 10 to the 90th. Moreover, in order to create a functioning protein the “amino acids, like letters in a meaningful sentence, must link up in functionally specified sequential arrangements.” It turns out that the probability for this is about one in 10 to the 74th. Thus, the probability of one functional protein of 150 amino acids forming by random chance is (1 in) 10 to the 164th. If we assume some minimally complex cell requires 250 different proteins then the probability of this arrangement happening purely by chance is one in 10 to the 164th multiplied by itself 250 times or one in 10 to the 41,000th power. *******www.spectrummagazine****/reviews/book_reviews/2009/10/06/signature_cell "No man-made program comes close to the technical brilliance of even Mycoplasmal genetic algorithms. Mycoplasmas are the simplest known organism with the smallest known genome, to date. How was its genome and other living organisms' genomes programmed?" - David L. Abel and Jack T. Trevors, “Three Subsets of Sequence Complexity and Their Relevance to Biopolymeric Information,” Theoretical Biology & Medical Modelling, Vol. 2, 11 August 2005, page 8 *******www.biomedcentral****/content/pdf/1742-4682-2-29.pdf First-Ever Blueprint of 'Minimal Cell' Is More Complex Than Expected - Nov. 2009 Excerpt: A network of research groups,, approached the bacterium at three different levels. One team of scientists described M. pneumoniae's transcriptome, identifying all the RNA molecules, or transcripts, produced from its DNA, under various environmental conditions. Another defined all the metabolic reactions that occurred in it, collectively known as its metabolome, under the same conditions. A third team identified every multi-protein complex the bacterium produced, thus characterising its proteome organisation. "At all three levels, we found M. pneumoniae was more complex than we expected," *******www.sciencedaily****/releases/2009/11/091126173027.htm Intelligent Design or Evolution? Stuart Pullen The chemical origin of life is the most vexing problem for naturalistic theories of life's origins. Despite an intense 50 years of research, how life can arise from non-life through naturalistic processes is as much a mystery today as it was fifty years ago, if not more. *******www.arn****/arnproducts/php/book_show_item.php?id=106 On The Origin Of Life And God - Henry F. Schaefer, III PhD. - video *******www.metacafe****/watch/4018204/the_origin_of_life_and_god_henry_fritz_schaefer_phd/ By the way, there is a one million dollar "Origin-of-Life" prize being offered: "The Origin-of-Life Prize" ® (hereafter called "the Prize") will be awarded for proposing a highly plausible mechanism for the spontaneous rise of genetic instructions in nature sufficient to give rise to life. *******www.us****/life/index.htm Intelligent Design - The Anthropic Hypothesis *******lettherebelight-77.blogspot****/
9 May 2010
8291
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1:21
Evolution Vs ATP Synthase - Molecular Machine - video *******www.metacafe****/watch/4012706 Evolution Vs. Functional Proteins - Where Did The Information Come From? - Doug Axe - Stephen Meyer - video *******www.metacafe****/watch/4018222 "There are no detailed Darwinian accounts for the evolution of any fundamental biochemical or cellular system only a variety of wishful speculations. It is remarkable that Darwinism is accepted as a satisfactory explanation of such a vast subject." James Shapiro - Molecular Biologist ATP Synthase achieves nearly 100% efficiency which far surpasses any human engineered motor: A rotary molecular motor that can work at near 100% efficiency: Excerpt: In cells, the free energy of ATP hydrolysis is ca. 90 pN nm per ATP molecule, suggesting that the F1 motor can work at near 100% efficiency. We confirmed in vitro that F1 indeed does ca. 80 pN nm of work under the condition where the free energy per ATP is 90 pN nm. The high efficiency may be related to the fully reversible nature of the F1 motor: *******rstb.royalsocietypublishing****/content/355/1396/473.abstract Worlds Smallest Rotary Engine Highlighted Excerpt: The match implies 100% efficiency for the conversion of the Gibbs free energy of ATP hydrolysis into mechanical work performed on the elastically strained filament. This is not surprising given the approximate thermodynamic equilibrium of the enzyme (long)-filament construct. *******www.creationsafaris****/crev200905.htm#20090525a ATP: The Perfect Energy Currency for the Cell Jerry Bergman, Ph.D. *******www.trueorigin****/atp.asp Astonishingly, and to the dismay of atheistic evolutionists, actual motors, which far surpass man-made motors in 'engineering parameters', are now being found inside 'simple cells'. Articles and Videos on Molecular Motors *******docs.google****/Doc?docid=0AYmaSrBPNEmGZGM4ejY3d3pfMzlkNjYydmRkZw&hl=en Bacterial Flagellum - A Sheer Wonder Of Intelligent Design - video *******www.metacafe****/watch/3994630 Biologist Howard Berg at Harvard calls the Bacterial Flagellum “the most efficient machine in the universe." Michael Behe on Falsifying Intelligent Design - video *******www.youtube****/watch?v=N8jXXJN4o_A The Cell as a Collection of Protein Machines "We have always underestimated cells. Undoubtedly we still do today,,, Indeed, the entire cell can be viewed as a factory that contains an elaborate network of interlocking assembly lines, each which is composed of a set of large protein machines." Bruce Alberts: Former President, National Academy of Sciences; *******www.imbb.forth.gr/people/aeconomou/documents/Alberts98.pdf The Cell - A World Of Complexity Darwin Never Dreamed Of - Donald E. Johnson - video *******www.metacafe****/watch/4139390 The inner life of a cell - Harvard University - video *******www.youtube****/watch?v=BtZEqQ1cpmk User's guide to the video *******sparkleberrysprings****/innerlifeofcell.html Cells Are Like Robust Computational Systems, - June 2009 Excerpt: "We now have reason to think of cells as robust computational devices, employing redundancy in the same way that enables large computing systems, such as Amazon, to keep operating despite the fact that servers routinely fail." *******www.sciencedaily****/releases/2009/06/090616103205.htm Simulations reveal new information about the gateway to the cell nucleus Excerpt: “There are whole machines in living cells that are made of hundreds or thousands of proteins,” says Schulten, “and the nuclear pore is one of those systems. It’s actually one of the most magnificent systems in the cell.”,,,Hundreds to thousands of NPCs are embedded in the nuclear envelope of each cell,"... *******www.psc.edu/science/2006/schulten/ Primary Cilium As Cellular 'GPS System' Crucial To Wound Repair Excerpt: The primary cilium, the solitary, antenna-like structure that studs the outer surfaces of virtually all human cells, orient cells to move in the right direction and at the speed needed to heal wounds, much like a Global Positioning System helps ships navigate to their destinations. "What we are dealing with is a physiological analogy to the GPS system with a coupled autopilot that coordinates air traffic or tankers on open sea," *******www.sciencedaily****/releases/2008/12/081217190330.htm Intelligent Design - The Anthropic Hypothesis *******lettherebelight-77.blogspot****/
31 Mar 2010
1779
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7:28
Three subsets of sequence complexity and their relevance to biopolymeric information - David L Abel and Jack T Trevors: Excerpt: Genetic algorithms instruct sophisticated biological organization. Three qualitative kinds of sequence complexity exist: random (RSC), ordered (OSC), and functional (FSC). FSC alone provides algorithmic instruction...No empirical evidence exists of either RSC of OSC ever having produced a single instance of sophisticated biological organization...It is only in researching the pre-RNA world that the problem of single-stranded metabolically functional sequencing of ribonucleotides (or their analogs) becomes acute. *******www.biomedcentral****/content/pdf/1742-4682-2-29.pdf Doug Axe humorously dismantled one of the latest ploys by materialists to oversell their meager evidence for a "self-replicating RNA molecule" in this following article: Biologic Institute Announces First Self-Replicating Motor Vehicle - Doug Axe - Excerpt: "So, advertising this as “self-replication” is a bit like advertising something as “free” when the actual deal is 1 free for every 1,600 purchased. It’s even worse, though, because you need lots of the pre-made precursors in cozy proximity to a finished RNA in order to kick the process off. That makes the real deal more like n free for every 1,600 n purchased, with the caveats that n must be a very large number and that full payment must be made in advance." *******biologicinstitute****/2009/04/01/biologic-institute-announces-first-self-replicating-motor-vehicle/ Stephen Meyer points out that intelligence design was clearly required for even this meager result: Biological Information: The Puzzle of Life that Darwinism Hasn’t Solved - Stephen C. Meyer Thus, as my book Signature in the Cell shows, Joyce’s experiments not only demonstrate that self-replication itself depends upon information-rich molecules, but they also confirm that intelligent design is the only known means by which information arises. *******www.evolutionnews****//2009/06/biological_information_the_puz.html Stephen Meyer Responds to Fletcher in Times Literary Supplement - Jan. 2010 Excerpt: everything we know about RNA catalysts, including those with partial self-copying capacity, shows that the function of these molecules depends upon the precise arrangement of their information-carrying constituents (i.e., their nucleotide bases). Functional RNA catalysts arise only once RNA bases are specifically-arranged into information-rich sequences—that is, function arises after, not before, the information problem has been solved. *******www.evolutionnews****/2010/01/stephen_meyer_responds_to_flet.html Materialists have not even created all 4 "letters" of RNA by natural means: Response to Darrel Falk’s Review of Signature in the Cell - Stephen Meyer - Jan. 2010 Excerpt: Sutherland’s work only partially addresses the first and least severe of these difficulties: the problem of generating the constituent building blocks or monomers in plausible pre-biotic conditions. It does not address the more severe problem of explaining how the bases in nucleic acids (either DNA or RNA) acquired their specific information-rich arrangements. *******www.signatureinthecell****/responses/response-to-darrel-falk.php Stirring the Soup - May 2009 "essentially, the scientists have succeeded in creating a couple of letters of the biological alphabet (in a "thermodynamically uphill" environment). What they need to do now is create the remaining letters, and then show how these letters were able to attach themselves together to form long chains of RNA, and arrange themselves in a specific order to encode information for creating specific proteins, and instructions to assemble the proteins into cells, tissues, organs, systems, and finally, complete phenotypes." Uncommon Descent - C Bass: *******www.uncommondescent****/intelligent-design/stirring-the-soup/#comments Scientists Say Intelligent Designer Needed for Origin of Life Chemistry Excerpt: Organic chemist Dr. Charles Garner recently noted in private correspondence that "while this work helps one imagine how RNA might form, it does nothing to address the information content of RNA. So, yes, there was a lot of guidance by an intelligent chemist." Sutherland's research produced only 2 of the 4 RNA nucleobases, and Dr. Garner also explained why, as is often the case, "the basic chemistry itself also required the hand of an intelligent chemist." *******www.evolutionnews****/2009/07/scientists_say_intelligent_des.html#more Meyer Responds to Stephen Fletcher - Stephen Meyer - March 2010 Excerpt: Nevertheless, this work does nothing to address the much more acute problem of explaining how the nucleotide bases in DNA or RNA acquired their specific information-rich arrangements, which is the central topic of my book (Signature In The Cell). In effect, the Powner (Sutherland) study helps explain the origin of the “letters” in the genetic text, but not their specific arrangement into functional “words” or “sentences.” *******www.evolutionnews****/2010/03/meyer_responds_to_stephen_flet.html Origin of Life: Claiming Something for Almost Nothing Excerpt: Yarus admitted, “the tiny replicator has not been found, and that its existence will be decided by experiments not yet done, perhaps not yet imagined.” But does this (laboratory) work support a naturalistic origin of life? A key question is whether a (self-replicating) molecule could form under plausible prebiotic conditions. Here’s how the paper described their work in the lab to get this (precursor) molecule: RNA was synthesized by Dharmacon. GUGGC = 5’-GUGGC-30 ; GCCU – 5’P-GCCU-3’ ; 5’OH-GCCU = 5’-GCCU-3’ ; GCCU20dU = 5’-GCC-2’-dU; GCC = 5’-GCC-3’ ; dGdCdCrU = 5’-dGdCdCU-3’ . RNA GCC3’dU was prepared by first synthesizing 5’-O-(4,4’- Dimethoxytrityl)3’-deoxyuridine as follows: 3’-deoxyuridine (MP Biomedicals; 991 mg, 0.434 mmol) was dissolved in 5 mL anhydrous pyridine and pyridine was then removed under vacuum while stirring. Solid was then redissolved in 2 mL pyridine. Dimethoxytrityl chloride (170 mg, 0.499 mmol) was dissolved in 12 mL pyridine and slowly added to 3’-deoxyuridine solution. Solution was stirred at room temperature for 4 h. All solutions were sequestered from exposure to air throughout. Reaction was then quenched by addition of 5 mL methanol, and solvent was removed by rotary evaporation. Remaining solvent evaporated overnight in a vacuum chamber. Product was then dissolved in 1 mL acetonitrile and purified through a silica column (acetonitrile elution). Final product fractions (confirmed through TLC, 1.1 hexane:acetonitrile) were pooled and rotary evaporated. Yield was 71%. Dimethoxytrityl-protected 30dU was then sent to Dharmacon for immobilization of 30-dU on glass and synthesis of 5’-GCC-3’-dU. PheAMP, PheUMP, and MetAMP were synthesized by the method of Berg (25) with modifications and purification as described in ref. 6. Yield was as follows: PheAMP 85%, PheUMP 67%, and MetAMP 36%. Even more purification and isolation steps under controlled conditions, using multiple solvents at various temperatures, were needed to prevent cross-reactions. (then this understatement follows) It is doubtful such complex lab procedures have analogues in nature. *******www.creationsafaris****/crev201003.htm#20100302a Here are some more critiques of the "RNA World" scenario: Did Life Begin in an RNA World? *******www.creationsafaris****/crev0702.htm#abiogenesis62 Self Replication and Perpetual Motion - The Second Law's Take On The RNA World *******theory-of-evolution****/chap10/self-replicating-RNA-perpetual-motion-4.php The RNA World: A Critique - Gordon Mills and Dean Kenyon: *******www.arn****/docs/odesign/od171/ribo171.htm Intelligent Design - The Anthropic Hypothesis *******lettherebelight-77.blogspot****/
2 May 2010
3330
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7:49
Among the other problems with the origin of even a single functional protein, Dr. Thaxton discusses the problem that specific sequences of Amino Acids (i.e. correct information) presents for 'natural' protein formation. Entire video may be viewed here: On The Origin Of Life - Thaxton *******www.youtube****/watch?v=6Ye3oDDAxeE Further resources: On The Origin Of Life And God - Henry F. Schaefer, III PhD. - video *******www.metacafe****/watch/4018204 Origin Of Life? - Probability Of Protein And The Information Of DNA - Dean Kenyon - video *******www.youtube****/watch?v=9VhR2BHhxeo In fact Dean Kenyon, who was a leading Origin Of Life researcher as well as a college textbook author on the subject, admitted after years of extensive research: "We have not the slightest chance for the chemical evolutionary origin of even the simplest of cells". Stephen C. Meyer - The Scientific Basis For the Intelligent Design Inference - video *******www.metacafe****/watch/4104651 Stephen Meyer - Functional Proteins And Information For Body Plans - video *******www.metacafe****/watch/4050681 Evolution vs. Functional Proteins - Doug Axe - Video *******www.metacafe****/watch/4018222 Estimating the prevalence of protein sequences adopting functional enzyme folds: Doug Axe: Excerpt: Starting with a weakly functional sequence carrying this signature, clusters of ten side-chains within the fold are replaced randomly, within the boundaries of the signature, and tested for function. The prevalence of low-level function in four such experiments indicates that roughly one in 10^64 signature-consistent sequences forms a working domain. Combined with the estimated prevalence of plausible hydropathic patterns (for any fold) and of relevant folds for particular functions, this implies the overall prevalence of sequences performing a specific function by any domain-sized fold may be as low as 1 in 10^77, adding to the body of evidence that functional folds require highly extraordinary sequences. *******www.ncbi.nlm.nih.gov/pubmed/15321723 Evolution's Fatal Flaw - The Origin Of Life - Chris Ashcraft PhD - video *******www.metacafe****/watch/4347153 The problem of 'left handed' homochirality found in the Miller-Urey experiment is of no small concern to any Origin Of Life scenario put forth by evolutionists: Dr. Charles Garner on the problem of Chirality in nature and Origin of Life Research - audio *******intelligentdesign.podomatic****/player/web/2010-04-12T17_21_16-07_00 Homochirality and Darwin - Robert Sheldon - April 2010 Excerpt: there is no abiotic path from a racemic solution to a stereo-active solution of amino acid(s) that doesn't involve a biotic chiral agent, be it chiral beads or Louis Pasteur himself. Like many critiques of ID, the problem with these "Darwinist" solutions is that they always smuggle in some information, in this case, chiral agents. *******procrustes.blogtownhall****/2010/04/27/homochirality_and_darwin.thtml Homochirality and Darwin: part 2 - Robert Sheldon - May 2010 Excerpt: With regard to the deniers who think homochirality is not much of a problem, I only ask whether a solution requiring multiple massive magnetized black-hole supernovae doesn't imply there is at least a small difficulty to overcome? A difficulty, perhaps, that points to the non-random nature of life in the cosmos? *******procrustes.blogtownhall****/2010/05/21/homochirality_and_darwin_part_2.thtml The severity of the homochirality problem begins to highlight the number one question facing any Origin Of Life research. Namely, "Where is the specified complexity (information) coming from?" Even this recent 'evolution friendly' article readily admitted the staggering level of 'specified complexity' (information) being dealt with in the first cell: Was our oldest ancestor a proton-powered rock? - Oct. 2009 Excerpt: “There is no doubt that the progenitor of all life on Earth, the common ancestor, possessed DNA, RNA and proteins, a universal genetic code, ribosomes (the protein-building factories), ATP and a proton-powered enzyme for making ATP. The detailed mechanisms for reading off DNA and converting genes into proteins were also in place. In short, then, the last common ancestor of all life looks pretty much like a modern cell.” *******www.newscientist****/article/mg20427306.200-was-our-oldest-ancestor-a-protonpowered-rock.html I think David Abel, the director of the Gene Emergence Project, does a very good job of highlighting just how crucial accounting for specified 'logical' information is to Origin of Life research: Chance and necessity do not explain the origin of life: Trevors JT, Abel DL. Excerpt: Minimal metabolism would be needed for cells to be capable of growth and division. All known metabolism is cybernetic--that is, it is programmatically and algorithmically organized and controlled. *******www.ncbi.nlm.nih.gov/pubmed/15563395 Intelligent Design - The Anthropic Hypothesis *******lettherebelight-77.blogspot****/2009/10/intelligent-design-anthropic-hypothesis_19.html
20 Sep 2010
1770
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6:05
The Cell - A World Of Complexity Darwin Never Dreamed Of - Donald E. Johnson - video *******www.metacafe****/watch/4139390 Articles and Videos on Molecular Motors *******docs.google****/Doc?docid=0AYmaSrBPNEmGZGM4ejY3d3pfMzlkNjYydmRkZw&hl=en Cells Are Like Robust Computational Systems, - June 2009 Excerpt: Gene regulatory networks in cell nuclei are similar to cloud computing networks, such as Google or Yahoo!, researchers report today in the online journal Molecular Systems Biology. The similarity is that each system keeps working despite the failure of individual components, whether they are master genes or computer processors. ,,,,"We now have reason to think of cells as robust computational devices, employing redundancy in the same way that enables large computing systems, such as Amazon, to keep operating despite the fact that servers routinely fail." *******www.sciencedaily****/releases/2009/06/090616103205.htm Systems biology: Untangling the protein web - July 2009 Excerpt: Vidal thinks that technological improvements — especially in nanotechnology, to generate more data, and microscopy, to explore interaction inside cells, along with increased computer power — are required to push systems biology forward. "Combine all this and you can start to think that maybe some of the information flow can be captured," he says. But when it comes to figuring out the best way to explore information flow in cells, Tyers jokes that it is like comparing different degrees of infinity. "The interesting point coming out of all these studies is how complex these systems are — the different feedback loops and how they cross-regulate each other and adapt to perturbations are only just becoming apparent," he says. "The simple pathway models are a gross oversimplification of what is actually happening." *******www.nature****/nature/journal/v460/n7253/full/460415a.html Three Subsets of Sequence Complexity and Their Relevance to Biopolymeric Information - David L. Abel and Jack T. Trevors - Theoretical Biology & Medical Modelling, Vol. 2, 11 August 2005, page 8 "No man-made program comes close to the technical brilliance of even Mycoplasmal genetic algorithms. Mycoplasmas are the simplest known organism with the smallest known genome, to date. How was its genome and other living organisms' genomes programmed?" *******www.biomedcentral****/content/pdf/1742-4682-2-29.pdf Simulations reveal new information about the gateway to the cell nucleus Excerpt: “There are whole machines in living cells that are made of hundreds or thousands of proteins,” says Schulten, “and the nuclear pore is one of those systems. It’s actually one of the most magnificent systems in the cell.”,,,Hundreds to thousands of NPCs are embedded in the nuclear envelope of each cell,"... *******www.psc.edu/science/2006/schulten/ Life Leads the Way to Invention - Feb. 2010 Excerpt: a cell is 10,000 times more energy-efficient than a transistor. “ In one second, a cell performs about 10 million energy-consuming chemical reactions, which altogether require about one picowatt (one millionth millionth of a watt) of power.” This and other amazing facts lead to an obvious conclusion: inventors ought to look to life for ideas.,,, Essentially, cells may be viewed as circuits that use molecules, ions, proteins and DNA instead of electrons and transistors. That analogy suggests that it should be possible to build electronic chips – what Sarpeshkar calls “cellular chemical computers” – that mimic chemical reactions very efficiently and on a very fast timescale. *******creationsafaris****/crev201002.htm#20100226a “Each cell with genetic information, from bacteria to man, consists of artificial languages and their decoding systems, memory banks for information storage and retrieval, elegant control systems regulating the automated assembly of parts and components, error fail-safe and proof-reading devices utilized for quality control, assembly processes involving the principle of prefabrication and modular construction and a capacity not equaled in any of our most advanced machines, for it would be capable of replicating its entire structure within a matter of a few hours" Geneticist Michael Denton PhD. Evolution: A Theory In Crisis pg. 329 "To grasp the reality of life as it has been revealed by molecular biology, we must first magnify a cell a thousand million times until it is 20 kilometers in diameter and resembles a giant airship large enough to cover a great city like London or New York. What we would see then would be an object of unparalleled complexity,...we would find ourselves in a world of supreme technology and bewildering complexity." Geneticist Michael Denton PhD., Evolution: A Theory In Crisis, pg.328 Michael Behe - Life Reeks Of Design - 2010 - video *******www.metacafe****/watch/5066181 And in spite of the fact of finding molecular motors permeating the simplest of bacterial life, there are no detailed Darwinian accounts for the evolution of even one such motor or system. "There are no detailed Darwinian accounts for the evolution of any fundamental biochemical or cellular system only a variety of wishful speculations. It is remarkable that Darwinism is accepted as a satisfactory explanation of such a vast subject. James Shapiro - Molecular Biologist The following expert doesn't even hide his very unscientific preconceived philosophical bias against intelligent design,,, ‘We should reject, as a matter of principle, the substitution of intelligent design for the dialogue of chance and necessity,,, Yet at the same time the same expert readily admits that neo-Darwinism has ZERO evidence for the chance and necessity of material processes producing any cellular system whatsoever,,, ,,,we must concede that there are presently no detailed Darwinian accounts of the evolution of any biochemical or cellular system, only a variety of wishful speculations.’ Franklin M. Harold,* 2001. The way of the cell: molecules, organisms and the order of life, Oxford University Press, New York, p. 205. *Professor Emeritus of Biochemistry, Colorado State University, USA Michael Behe - No Scientific Literature For Evolution of Any Irreducibly Complex Molecular Machines *******www.metacafe****/watch/5302950/ “The response I have received from repeating Behe's claim about the evolutionary literature, which simply brings out the point being made implicitly by many others, such as Chris Dutton and so on, is that I obviously have not read the right books. There are, I am sure, evolutionists who have described how the transitions in question could have occurred.” And he continues, “When I ask in which books I can find these discussions, however, I either get no answer or else some titles that, upon examination, do not, in fact, contain the promised accounts. That such accounts exist seems to be something that is widely known, but I have yet to encounter anyone who knows where they exist.” David Ray Griffin - retired professor of philosophy of religion and theology Doug Axe Knows His Work Better Than Steve Matheson Excerpt: Regardless of how the trials are performed, the answer ends up being at least half of the total number of password possibilities, which is the staggering figure of 10^77 (written out as 100, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000, 000). Armed with this calculation, you should be very confident in your skepticism, because a 1 in 10^77 chance of success is, for all practical purposes, no chance of success. My experimentally based estimate of the rarity of functional proteins produced that same figure, making these likewise apparently beyond the reach of chance. *******www.evolutionnews****/2010/06/doug_axe_knows_his_work_better035561.html Evolution vs. Functional Proteins - Doug Axe - Video *******www.metacafe****/watch/4018222 Intelligent Design - The Anthropic Hypothesis *******lettherebelight-77.blogspot****/2009/10/intelligent-design-anthropic-hypothesis_19.html
31 Jul 2011
2502
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Entire video: Creation/Evolution: Natural Limits to Biological Change - Dr. Raymond G. Bohlin - video (presentation starts at the 13:00 minute mark of video) *******www.youtube****/watch?v=Dk9wmQP7SdM&feature=bf_prev&list=SP9C519B84FE6C1202 With a Startling Candor, Oxford Scientist Admits a Gaping Hole in Evolutionary Theory - November 2011 Excerpt: As of now, we have no good theory of how to read [genetic] networks, how to model them mathematically or how one network meshes with another; worse, we have no obvious experimental lines of investigation for studying these areas. There is a great deal for systems biology to do in order to produce a full explanation of how genotypes generate phenotypes,,, *******www.evolutionnews****/2011/11/with_a_startling_candor_oxford052821.html The next evolutionary synthesis: Jonathan BL Bard (2011) Excerpt: We now know that there are at least 50 possible functions that DNA sequences can fulfill [8], that the networks for traits require many proteins and that they allow for considerable redundancy [9]. The reality is that the evolutionary synthesis says nothing about any of this; for all its claim of being grounded in DNA and mutation, it is actually a theory based on phenotypic traits. This is not to say that the evolutionary synthesis is wrong, but that it is inadequate – it is really only half a theory! *******www.biosignaling****/content/pdf/1478-811X-9-30.pdf New level of genetic diversity in human RNA sequences uncovered Excerpt: A detailed comparison of DNA and RNA in human cells has uncovered a surprising number of cases where the corresponding sequences are not, as has long been assumed, identical. The RNA-DNA differences generate proteins that do not precisely match the genes that encode them.,,, Nearly half of the RDDs uncovered in the new study cannot be explained by the activity of deaminase enzymes, however, indicating that unknown processes must be modifying the RNA sequence, either during or after transcription. ,,, Although all of the individuals analyzed in the study had a large number of RDDs, there was a great deal of variability in the specific RDDs found in each person's genetic material." *******www.physorg****/news/2011-05-genetic-diversity-human-rna-sequences.html The Fate of Darwinism: Evolution After the Modern Synthesis - David J. Depew and Bruce H. Weber - 2011 Excerpt: We trace the history of the Modern Evolutionary Synthesis, and of genetic Darwinism generally, with a view to showing why, even in its current versions, it can no longer serve as a general framework for evolutionary theory. The main reason is empirical. Genetical Darwinism cannot accommodate the role of development (and of genes in development) in many evolutionary processes.,,, *******www.springerlink****/content/845x02v03g3t7002/ Modern Synthesis of Neo-Darwinism Is Dead - No Evidence For Body Plan Morphogenesis From Embryonic Mutations - Paul Nelson - video *******www.metacafe****/watch/5548184/ In Embryo Development, Non-DNA Information Is at Least as Important as DNA - Jonathan Wells - May 2012 Excerpt: Evidence shows that non-DNA developmental information can be inherited in several ways. For example, it can be inherited through chromatin modifications, which affect gene expression without altering underlying DNA sequences. Another example is cytoplasmic inheritance, which involves cytoskeletal patterns and localization of intracellular molecules. Still another example is cortical inheritance, which involves membrane patterns. *******www.evolutionnews****/2012/05/in_embryo_devel060031.html “Live memory” of the cell, the other hereditary memory of living systems - 2005 Excerpt: To understand this notion of “live memory”, its role and interactions with DNA must be resituated; indeed, operational information belongs as much to the cell body and to its cytoplasmic regulatory protein components and other endogenous or exogenous ligands as it does to the DNA database. We will see in Section 2, using examples from recent experiments in biology, the principal roles of “live memory” in relation to the four aspects of cellular identity, memory of form, hereditary transmission and also working memory. *******www.ncbi.nlm.nih.gov/pubmed/15888340 Poly-Functional Complexity equals Poly-Constrained Complexity ********docs.google****/document/d/1xkW4C7uOE8s98tNx2mzMKmALeV8-348FZNnZmSWY5H8/edit Systems biology: Untangling the protein web - July 2009 Excerpt: Vidal thinks that technological improvements — especially in nanotechnology, to generate more data, and microscopy, to explore interaction inside cells, along with increased computer power — are required to push systems biology forward. "Combine all this and you can start to think that maybe some of the information flow can be captured," he says. But when it comes to figuring out the best way to explore information flow in cells, Tyers jokes that it is like comparing different degrees of infinity. "The interesting point coming out of all these studies is how complex these systems are — the different feedback loops and how they cross-regulate each other and adapt to perturbations are only just becoming apparent," he says. "The simple pathway models are a gross oversimplification of what is actually happening." *******www.nature****/nature/journal/v460/n7253/full/460415a.html Stephen Meyer - Functional Proteins And Information For Body Plans - video *******www.metacafe****/watch/4050681 Dr. Stephen Meyer comments at the end of the preceding video,,, ‘Now one more problem as far as the generation of information. It turns out that you don’t only need information to build genes and proteins, it turns out to build Body-Plans you need higher levels of information; Higher order assembly instructions. DNA codes for the building of proteins, but proteins must be arranged into distinctive circuitry to form distinctive cell types. Cell types have to be arranged into tissues. Tissues have to be arranged into organs. Organs and tissues must be specifically arranged to generate whole new Body-Plans, distinctive arrangements of those body parts. We now know that DNA alone is not responsible for those higher orders of organization. DNA codes for proteins, but by itself it does insure that proteins, cell types, tissues, organs, will all be arranged in the body. And what that means is that the Body-Plan morphogenesis, as it is called, depends upon information that is not encoded on DNA. Which means you can mutate DNA indefinitely. 80 million years, 100 million years, til the cows come home. It doesn’t matter, because in the best case you are just going to find a new protein some place out there in that vast combinatorial sequence space. You are not, by mutating DNA alone, going to generate higher order structures that are necessary to building a body plan. So what we can conclude from that is that the neo-Darwinian mechanism is grossly inadequate to explain the origin of information necessary to build new genes and proteins, and it is also grossly inadequate to explain the origination of novel biological form.’ - Stephen Meyer - (excerpt taken from Meyer/Sternberg vs. Shermer/Prothero debate - 2009) "Charles Darwin said (paraphrase), 'If anyone could find anything that could not be had through a number of slight, successive, modifications, my theory would absolutely break down.' Well that condition has been met time and time again. Basically every gene, every protein fold. There is nothing of significance that we can show that can be had in a gradualist way. It's a mirage. None of it happens that way. - Doug Axe PhD. Nothing In Molecular Biology Is Gradual - Doug Axe PhD. *******www.metacafe****/watch/5347797/ From Jerry Coyne, More Table-Pounding, Hand-Waving - May 2012 Excerpt: "More than 6 percent of genes found in humans simply aren't found in any form in chimpanzees. There are over fourteen hundred novel genes expressed in humans but not in chimps." Jerry Coyne - ardent and 'angry' neo-Darwinist - professor at the University of Chicago in the department of ecology and evolution for twenty years. He specializes in evolutionary genetics. *******www.evolutionnews****/2012/05/from_jerry_coyn060271.html Study Reports a Whopping "23% of Our Genome" Contradicts Standard Human-Ape Evolutionary Phylogeny - Casey Luskin - June 2011 Excerpt: For about 23% of our genome, we share no immediate genetic ancestry with our closest living relative, the chimpanzee. This encompasses genes and exons to the same extent as intergenic regions. We conclude that about 1/3 of our genes started to evolve as human-specific lineages before the differentiation of human, chimps, and gorillas took place. (of note; 1/3 of our genes is equal to about 7000 genes that we do not share with chimpanzees) *******www.evolutionnews****/2011/06/study_reports_a_whopping_23_of047041.html Could Chance Arrange the Code for (Just) One Gene? Excerpt: "our minds cannot grasp such an extremely small probability as that involved in the accidental arranging of even one gene (10^-236)." *******www.creationsafaris****/epoi_c10.htm Guy Walks Into a Bar and Thinks He's a Chimpanzee: The Unbearable Lightness of Chimp-Human Genome Similarity - Richard Sternberg - May 2009 *******www.evolutionnews****/2009/05/guy_walks_into_a_bar_and_think020401.html The Gorilla Who Broke the Tree - Doug Axe PhD. - March 2012 Excerpt: Well, the recent publication of the gorilla genome sequence shows that the expected pattern just isn’t there. Instead of a nested hierarchy of similarities, we see something more like a mosaic. According to a recent report [1], “In 30% of the genome, gorilla is closer to human or chimpanzee than the latter are to each other…” That’s sufficiently difficult to square with Darwin’s tree that it ought to bring the whole theory into question. And in an ideal world where Darwinism is examined the way scientific theories ought to be examined, I think it would. But in the real world things aren’t always so simple. *******www.biologicinstitute****/post/19703401390/the-gorilla-who-broke-the-tree Chimps are not like humans - May 2004 Excerpt: the International Chimpanzee Chromosome 22 Consortium reports that 83% of chimpanzee chromosome 22 proteins are different from their human counterparts,,, The results reported this week showed that "83% of the genes have changed between the human and the chimpanzee—only 17% are identical—so that means that the impression that comes from the 1.2% [sequence] difference is [misleading]. In the case of protein structures, it has a big effect," Sakaki said. *******cmbi.bjmu.edu.cn/news/0405/119.htm Chimp chromosome creates puzzles - 2004 Excerpt: However, the researchers were in for a surprise. Because chimps and humans appear broadly similar, some have assumed that most of the differences would occur in the large regions of DNA that do not appear to have any obvious function. But that was not the case. The researchers report in 'Nature' that many of the differences were within genes, the regions of DNA that code for proteins. 83% of the 231 genes compared had differences that affected the amino acid sequence of the protein they encoded. And 20% showed "significant structural changes". In addition, there were nearly 68,000 regions that were either extra or missing between the two sequences, accounting for around 5% of the chromosome.,,, "we have seen a much higher percentage of change than people speculated." The researchers also carried out some experiments to look at when and how strongly the genes are switched on. 20% of the genes showed significant differences in their pattern of activity. *******www.nature****/news/1998/040524/full/news040524-8.html Eighty percent of proteins are different between humans and chimpanzees; Gene; Volume 346, 14 February 2005: *******www.ncbi.nlm.nih.gov/pubmed/15716009 Further notes: Falsification Of Neo-Darwinism by Quantum Entanglement/Information ********docs.google****/document/d/1p8AQgqFqiRQwyaF8t1_CKTPQ9duN8FHU9-pV4oBDOVs/edit Let There Be Light - Intelligent Design - The Anthropic Hypothesis *******lettherebelight-77.blogspot****/2012/02/let-there-be-light.html
2 Jun 2012
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