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This is my first video of some different cells that I made by hand I need some good tools
HHO testing With SS Coil W/Center Rods SS and Double Helix testing SS
An excellent animation which explains the hiv replication very clearly.
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The Lyrics of this video is here
Targeting HIV replication
The replication of HIV 1 is a multi-stage process.
Each step is crucial to successful replication and is therefore a potential target of antiretroviral drugs.
Step one is the infection of a suitable host-cell, such as a CD4-positive T-lymphocyte.
Entry of HIV into the cell requires the presence of certain receptors on the cell surface, CD4 -- receptors and co-receptors such as CCR5 or CXCR4.
These receptors interact with protein-complexes, which are embedded in the viral envelope.
These complexes are composed of two glycoproteins:
an extracellular gp 120 and
a transmembrane gp 41
When HIV approaches the target cell gp120 binds to the CD4-receptors. This process is termed attachment.
It promotes further binding to a co-receptor. Co-receptor binding results in a conformational change in gp120.
This allows gp41 to unfold and insert its hydrophobic terminus into the cell membrane.
Gp 41 then folds back on itself.
This draws the virus towards the cell and facilitates the fusion of their membranes.
The viral nucleocapsid enters the host cell and breaks open releasing two viral RNA-strands and 3 essential replication enzymes:
Integrase, Protease and Reverse Transcriptase.
Reverse Transcriptase begins the reverse transcription of viral RNA.
It has two catalytic domains:
The Ribonuclease-H active site
And the polymerase active site
Here single stranded viral RNA is transcribed into an RNA-DNA double helix. Ribonuclease- H breaks down the RNA.
The polymerase then completes the remaining DNA-strand to form a DNA -- double helix.
Now Integrase goes into action.
It cleaves a dinucleotide from each 3-prime end of the DNA creating two sticky ends.
Integrase then transfers the DNA into the cell nucleus and facilitates its integration into the host cell genome.
The host cell genome now contains the genetic information of HIV.
Activation of the cell induces transcription of proviral DNA into messenger RNA.
The viral messenger RNA migrates into the cytoplasm where building blocks for a new virus are synthesised.
Some of them have to be processed by the viral protease.
Protease cleaves longer proteins into smaller core proteins.
This step is crucial to create an infectious virus.
Two viral RNA-strands and the replication enzymes then come together and core proteins assemble around them forming the capsid.
This immature particle leaves the cell acquiring a new envelope of host and viral proteins.
The virus matures and becomes ready to infect other cells.
HIV replicates billions of times per day destroying the hosts` immune cells and eventually causing disease progression.
Drugs which interfere with the key steps of viral replication can stop this fatal process.
Entry into the host cell can be blocked by fusion inhibitors for example.
Inhibition of reverse transcriptase by nucleoside inhibitors or by non-nucleoside Reverse Transcriptase- inhibitors is part of standard antiretroviral regimens.
The action of Integrase can be blocked.
Protease inhibitors are also part of standard antiretroviral therapy.
Each blocked step in viral replication is a step towards better control of HIV disease.
Script, Storyboard, Art Direction by: Frank Schauder, MD
Publicity: Dr.Rufus Rajadurai.MD.,D.DENS.,
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Battleship game review. Classic Game Room reviews BATTLESHIP for Xbox 360 from Double Helix and Activision, the video game based on the movie based on the board game based on sinking Battleships! You sank my Battleship (copyright TM)!!!! Battleship video game is available for Xbox 360 and PlayStation 3 PS3, Battleship is also available on Nintendo Wii, DS and 3DS but for those versions it is a turn based strategy game. This version of Battleship videogame is a combo first person shooter and tactical naval strategy game!
Front Mission Evolved review. *******www.ClassicGameRoom**** Classic Game Room reviews FRONT MISSION EVOLVED for Xbox 360 (also available for PlayStation 3 PS3 and PC) from Double Helix Games and Square Enix. While far from the awesome-town releases of Front Mission 3, Front Mission 4 and the other tactical strategy RPG video games, Front Mission Evolved has giant robots with guns and explosions... so it's got that. A terrible script, bad acting and sloppy gameplay make this 2010 action game from from perfect but not without merit. Earn money by destroying enemies and invest that money in your Wanzer (aka giant, big-ass robot). Building your own robot and outfitting it with guns and missile launches is the highlight of Front Mission Evolved and it has some descent action and gameplay to keep you playing through to the silly end. CGR Front Mission Evolved video review features Front Mission Evolved game play recorded from Xbox 360.
The Classic Game Room Media Empire proudly presents a CGRundertow video game review of FRONT MISSION EVOLVED for the PlayStation 3 (PS3) from Double Helix and Square Enix. Released on September 28th, FRONT MISSION EVOLVED is also available on the PC and Xbox 360 platforms. FRONT MISSION EVOLVED will be the first third-person shooter entry into the franchise's history. This CGRundertow video game review features FRONT MISSION EVOLVED video gameplay footage and commentary. This video game review is from CGR reviewer Derek.
Classic Game Room presents a CGRundertow review of Green Lantern: Rise of the Manhunters from Double Helix and Warner Bros. Interactive for the PlayStation 3. Green Lantern: Rise of the Manhunters is also available for the Nintendo Wii, Nintendo 3DS, Nintendo DS and Xbox 360. You play as a model of Ryan Reynolds with a generic haircut. This is a beat 'em up similar to the countless other movie games that are also beat 'em ups. And uh, and also something called God of War. Strange enough, the game also adds on rails flight missions, kind of like a Sin and Punishment: Kindergarten Edition. This game has everything you'd expect. Button mashing combat, collectible orbs, cooperative multiplayer, situational quick-time events and lots of unabashed Kratos praise. And of course, it's also lacking everything you'd expect, including inspired gameplay, fun design or any conceivable reason to purchase it. This video review features video gameplay footage of Green Lantern: Rise of the Manhunters for the PlayStation 3 and audio commentary from Classic Game Room's Derek.
Strider trailer. *******www.ClassicGameRoom****
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Classic Game Room’s CGR Trailers presents a gameplay trailer for STRIDER® from Double Helix and Capcom just in time for San Diego Comic Con (SDCC) 2013. Strider Hiryu returns in this side-scrolling platformer in a ravage apocalyptic Earth that sets the stage for this game. Get a glimpse at what to expect when picking up this game with this trailer. This ninja assassin is now coming to the Windows PC, PlayStation 3 (PS3), PlayStation 4 (PS4), Xbox 360 and Xbox One video game platforms in 2014. This is a downloadable title. It isn’t currently rated by the ESRB. Stay tuned for more information to come in the future. Enjoy!
Great story of our second customer since we launched our website Discover Helix. Joe has a unique reason for why he bought from us and how long he's been wearing them. Check it out!
just some of the flourishes i can do
[im ready and willing to make tutorials for the ones i made!!]